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exostosin-like glycosyltransferase 2

Summary

Gene Symbol

Extl2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

58193

KEGG Gene ID

mmu:58193

PubChem

58193

Alliance of Genome Resources

MGI:1889574

Annotation

Keyword

3D-structure
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Manganese
Metal-binding
Proteomics identification
Reference proteome
Signal
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9ES89	Alpha-1,4-N-acetylhexosaminyltransferase EXTL2 Alpha-GalNAcT EXTL2 EXT-related protein 2 Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
Q8C089
Q3TSR0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
N-acetylglucosamine metabolic process	ISO
N-acetylglucosamine metabolic process	IMP	12562774
UDP-N-acetylgalactosamine metabolic process	ISO
UDP-N-acetylgalactosamine metabolic process	IMP	12562774

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

organic substance metabolic process [inference]

carbohydrate derivative metabolic process [inference]

amino sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

glucosamine-containing compound metabolic process [inference]

N-acetylglucosamine metabolic process

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

phosphorus metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-N-acetylgalactosamine metabolic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IEA
cytosol	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	ISO
glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity	IEA
glycosaminoglycan binding	IMP	12562774
glycosyltransferase activity
manganese ion binding	IMP	12562774

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

acetylgalactosaminyltransferase activity [inference]

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

acetylgalactosaminyltransferase activity [inference]

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Exostosin-like

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
transferase activity

Displaying **all 2** entries
InterPro
Glycosyl transferase 64 domain
Nucleotide-diphospho-sugar transferases

Rhea

RHEA:16221

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.223

PMID

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	2135	Xenbase:XB-GENE-1001404	HUMAN50943
Xenopus tropicalis	58193	Xenbase:XB-GENE-1001404
Rattus norvegicus	310803	Xenbase:XB-GENE-1001404	RATNO23406
Xenopus tropicalis	443929	Xenbase:XB-GENE-1001404
Pan troglodytes	457060		PANTR21685
Canis lupus familiaris	479925		CANLF16865
Xenopus tropicalis	493327	Xenbase:XB-GENE-1001404
Bos taurus	540527		BOVIN26418
Danio rerio	558373	Xenbase:XB-GENE-1001404	DANRE29049
Macaca mulatta	712189		MACMU23287

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements