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ATP binding cassette subfamily D member 3

Summary

Gene Symbol

ABCD3

Aliases

PMP70
ZWS2
peroxisomal membrane protein 70 kDa

Organism

Homo sapiens (human)

External Links

NCBI Gene

5825

HGNC

KEGG Gene ID

PubChem

5825

Alliance of Genome Resources

HGNC:67

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Glycoprotein
Hydrolase
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Translocase
Transmembrane helix
Transport
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P28288	70 kDa peroxisomal membrane protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
very long-chain fatty acid metabolic process	IDA
fatty acid biosynthetic process	IMP
fatty acid beta-oxidation	IDA
fatty acid beta-oxidation	IGI
fatty acid beta-oxidation	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

lipid catabolic process [inference]

fatty acid catabolic process [inference]

small molecule catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

phytanic acid metabolic process

fatty acid biosynthetic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

methyl-branched fatty acid metabolic process [inference]

phytanic acid metabolic process

steroid metabolic process [inference]

bile acid metabolic process [inference]

bile acid biosynthetic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process

lipid catabolic process [inference]

fatty acid catabolic process [inference]

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

small molecule metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

phytanic acid metabolic process

fatty acid biosynthetic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

methyl-branched fatty acid metabolic process [inference]

phytanic acid metabolic process

bile acid metabolic process [inference]

bile acid biosynthetic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

monocarboxylic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

small molecule catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

small molecule biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

intercellular transport [inference]

long-chain fatty acid import into peroxisome

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

transmembrane transport

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

peroxisome organization

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport

bile acid and bile salt transport

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into peroxisome

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

intercellular transport [inference]

long-chain fatty acid import into peroxisome

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

bile acid and bile salt transport

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into peroxisome

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

organic hydroxy compound transport [inference]

bile acid and bile salt transport

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

transmembrane transport

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
mitochondrion	IEA
peroxisome	IDA
peroxisome	IEA
peroxisomal membrane	EXP
peroxisomal membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
long-chain fatty acid transmembrane transporter activity	IMP
long-chain fatty acid transmembrane transporter activity	IBA
long-chain fatty acid transmembrane transporter activity	IEA
protein binding	IPI
ATP binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

deacylase activity [inference]

acyl-CoA hydrolase activity [inference]

fatty acyl-CoA hydrolase activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

carboxylic acid transmembrane transporter activity [inference]

monocarboxylic acid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity

lipid transmembrane transporter activity [inference]

fatty acid transmembrane transporter activity [inference]

long-chain fatty acid transmembrane transporter activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000117528

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:905	Zellweger syndrome	Alliance of Genome Resources
DOID:0111066	congenital bile acid synthesis defect 5	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 15 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000952	Jaundice
HP:0001395	Hepatic fibrosis
HP:0001399	Hepatic failure
HP:0001409	Portal hypertension
HP:0001744	Splenomegaly
HP:0001891	Iron deficiency anemia
HP:0002240	Hepatomegaly
HP:0002904	Hyperbilirubinemia
HP:0002910	Elevated circulating hepatic transaminase concentration