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sodium voltage-gated channel beta subunit 2

Summary

Gene Symbol

SCN2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

6327

PubChem

6327

Alliance of Genome Resources

HGNC:10589

Annotation

Keyword

3D-structure
Atrial fibrillation
Brugada syndrome
Disease variant
Disulfide bond
Glycoprotein
Immunoglobulin domain
Ion channel
Phosphoprotein
Reference proteome
Signal
Sodium channel
Transmembrane helix
Voltage-gated channel

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O60939
Q5U0K8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
response to pyrethroid	IEA
cardiac muscle contraction	IMP	19808477
cardiac muscle cell action potential involved in contraction	IBA IMP	19808477
membrane depolarization during action potential	IDA	35277491
membrane repolarization during ventricular cardiac muscle cell action potential	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to chemical [inference]

response to toxic substance [inference]

response to insecticide [inference]

response to pyrethroid

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

positive regulation of sodium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

cardiac conduction

regulation of heart rate by cardiac conduction

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction

regulation of membrane depolarization [inference]

regulation of atrial cardiac muscle cell membrane depolarization

membrane depolarization [inference]

membrane depolarization during action potential

membrane depolarization during cardiac muscle cell action potential

membrane repolarization [inference]

membrane repolarization during action potential [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

membrane repolarization during ventricular cardiac muscle cell action potential

cardiac muscle cell membrane repolarization [inference]

membrane repolarization during cardiac muscle cell action potential [inference]

membrane repolarization during ventricular cardiac muscle cell action potential

ventricular cardiac muscle cell membrane repolarization [inference]

membrane repolarization during ventricular cardiac muscle cell action potential

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
T-tubule	IEA
voltage-gated sodium channel complex	IBA IDA TAS	19808477 35277491 36823201 9295116
plasma membrane	IBA IDA	35277491
axon initial segment	IEA
node of Ranvier	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex [inference]

voltage-gated sodium channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

Displaying **all 3** entries
GO Term	Evidence Code	PMID
sodium channel regulator activity	IBA IDA	19808477
voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IEA
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity [inference]

voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [inference]

voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity [inference]

voltage-gated sodium channel activity involved in cardiac muscle cell action potential

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

sodium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sodium channel subunit beta-2

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
sodium channel regulator activity

Displaying **all 6** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Myelin P0 protein-related

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050650	familial atrial fibrillation	Alliance of Genome Resources
DOID:10754	otitis media	Alliance of Genome Resources
DOID:11832	visual epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	25349		RGD:3633	RATNO40797
Mus musculus	72821		MGI:106921	MOUSE62973
Pan troglodytes	466796	9598_0:003096		PANTR04454
Xenopus laevis	494804		Xenbase:XB-GENE-921742
Bos taurus	538722			BOVIN06540
Macaca mulatta	678698			MACMU10229
Danio rerio	777666		ZFIN:ZDB-GENE-070920-1	DANRE09166
Monodelphis domestica	100025272			MONDO24874
Equus caballus	100062848			HORSE39222
Xenopus tropicalis	100144663		Xenbase:XB-GENE-921739

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements