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Glycan Structure Repository
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Glycomics MS raw data Repository
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Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
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GALAXY
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Guidelines
MIRAGE
nucleotide binding oligomerization domain containing 2
Summary
- Gene Symbol
-
- NOD2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- ATP-binding
- Adaptive immunity
- Alternative initiation
- Autophagy
- Cell membrane
- Cytoplasm
- Disease variant
- Glycoprotein
- Innate immunity
- Leucine-rich repeat
- Mitochondrion
- Palmitate
- Proteomics identification
- Reference proteome
- Repeat
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A286YF65 |
|
| Q9HC29 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| temperature homeostasis | ||
| pattern recognition receptor signaling pathway | ||
| innate immune response in mucosa | ||
| adaptive immune response | ||
| positive regulation of dendritic cell antigen processing and presentation |
GO Hierarchy
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-17 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
biological process
immune system process [inference]
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of immune effector process [inference]
positive regulation of immune effector process [inference]
regulation of production of molecular mediator of immune response [inference]
regulation of leukocyte mediated immunity [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of adaptive immune response [inference]
regulation of humoral immune response [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
negative regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cytokine production involved in immune response [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
negative regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cytokine production involved in immune response [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
regulation of cellular catabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of amide metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
negative regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cytokine production involved in immune response [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of response to stimulus [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of antimicrobial humoral response [inference]
positive regulation of response to biotic stimulus [inference]
regulation of innate immune response [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
regulation of antimicrobial humoral response [inference]
positive regulation of response to external stimulus [inference]
regulation of innate immune response [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of adaptive immune response [inference]
regulation of humoral immune response [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of response to stress [inference]
regulation of defense response [inference]
regulation of antimicrobial humoral response [inference]
positive regulation of defense response [inference]
regulation of innate immune response [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
negative regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cytokine production involved in immune response [inference]
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
regulation of cellular catabolic process [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production [inference]
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cellular biosynthetic process [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of gene expression [inference]
regulation of cell activation [inference]
regulation of cellular component organization [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
negative regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cytokine production involved in immune response [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| actin binding | ||
| protein binding | ||
| ATP binding | ||
| enzyme binding | ||
| protein kinase binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Leucine Rich repeat
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- P: Inorganic ion transport and metabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Leucine-rich repeat domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050678 | Blau syndrome | |
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0050922 | gastrointestinal carcinoma | |
| DOID:0080176 | meningococcal meningitis | |
| DOID:0081267 | graft-versus-host disease | |
| DOID:0081451 | PFAPA syndrome | |
| DOID:1024 | leprosy | |
| DOID:1324 | lung cancer | |
| DOID:13241 | Behcet's disease | |
| DOID:13406 | pulmonary sarcoidosis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100018299 | MONDO06614 | ||
| 100059123 | HORSE30436 | ||
| 100090933 | ORNAN03031 | ||
| 100125838 | PIGXX27474 | ||
| 100356594 | RABIT15025 | ||
| 100379166 | ICTPU21861 | ||
| 100414962 | CALJA21236 | ||
| 100440517 | PONAB11010 | ||
| 100469482 | AILME17849 | ||
| 100590851 | NOMLE24320 |
