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MIRAGE
Nucleotide-binding oligomerization domain-containing protein 2
Summary
- UniProt ID
- Q9HC29
- Gene Symbol
-
- CARD15
- NOD2
- Gene ID
- 64127
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- Q9HC29
- PubChem
- Q9HC29
- The Human Metabolome Database
- HMDBP13949
- Re-Glyco
- Q9HC29
Annotation
- Keyword
-
- ATP-binding
- Adaptive immunity
- Alternative initiation
- Autophagy
- Cell membrane
- Cytoplasm
- Disease variant
- Glycoprotein
- Innate immunity
- Leucine-rich repeat
- Mitochondrion
- Palmitate
- Reference proteome
- Repeat
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| mitochondrion |
| cytoskeleton |
| plasma membrane |
| vesicle |
| protein-containing complex |
| Golgi apparatus |
| cytosol |
| cell surface |
| basolateral plasma membrane |
| GO Term |
|---|
| muramyl dipeptide binding |
| pattern recognition receptor activity |
| peptidoglycan binding |
| CARD domain binding |
| actin binding |
| ATP binding |
| enzyme binding |
| protein kinase binding |
| Hsp70 protein binding |
| ubiquitin binding |
Sequence
MGEEGGSASHDEEERASVLLGHSPGCEMCSQEAFQAQRSQLVELLVSGSLEGFESVLDWLLSWEVLSWEDYEGFHLLGQPLSHLARRLLDTVWNKGTWACQKLIAAAQEAQADSQSPKLHGCWDPHSLHPARDLQSHRPAIVRRLHSHVENMLDLAWERGFVSQYECDEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCKKYMAKLRTTVSAQSRFLSTYDGAETLCLEDIYTENVLEVWADVGMAGPPQKSPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLVRAKGVVPGSTAPLEFLHITFQCFFAAFYLALSADVPPALLRHLFNCGRPGNSPMARLLPTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVHAMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRLLL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 777 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Interleukin-1 signaling | Homo sapiens |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 | Homo sapiens |
| NOD1/2 Signaling Pathway | Homo sapiens |
| Ovarian tumor domain proteases | Homo sapiens |
| SARS-CoV-2 activates/modulates innate and adaptive immune responses | Homo sapiens |
| TAK1-dependent IKK and NF-kappa-B activation | Homo sapiens |
| activated TAK1 mediates p38 MAPK activation | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050678 | Blau syndrome | |
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0050922 | gastrointestinal carcinoma | |
| DOID:0080176 | meningococcal meningitis | |
| DOID:0081267 | graft-versus-host disease | |
| DOID:0081451 | PFAPA syndrome | |
| DOID:1024 | leprosy | |
| DOID:1324 | lung cancer | |
| DOID:13241 | Behcet's disease | |
| DOID:13406 | pulmonary sarcoidosis |
