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inducible T-cell co-stimulator

Summary

Gene Symbol

Icos

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

64545

PubChem

64545

Alliance of Genome Resources

RGD:620123

Annotation

Keyword

Alternative splicing
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6IPD8
A6IPD9
Q9R1T7	Activation-inducible lymphocyte immunomediatory molecule

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cell-cell adhesion	IBA IDA	10607749
T cell tolerance induction	IBA IMP	16220623
T cell costimulation	IBA IDA IEA	11006126

GO Hierarchy

biological process

immune system process [inference]

tolerance induction [inference]

T cell tolerance induction

lymphocyte costimulation [inference]

T cell costimulation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	ISO
membrane	IEA
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Inducible T-cell costimulator

Functional Category

K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
T cell costimulation
T cell tolerance induction

Displaying **all 3** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin-like fold
Inducible T-cell costimulator

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060025	immunoglobulin alpha deficiency	Alliance of Genome Resources
DOID:0060180	colitis	Alliance of Genome Resources
DOID:0081144	common variable immunodeficiency 1	Alliance of Genome Resources
DOID:10608	celiac disease	Alliance of Genome Resources
DOID:12177	common variable immunodeficiency	Alliance of Genome Resources
DOID:13141	uveitis	Alliance of Genome Resources
DOID:820	myocarditis	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Melopsittacus undulatus	101868867			MELUD15188
Chrysemys picta bellii	101945045			CHRPI31144
Ictidomys tridecemlineatus	101967223	43179_0:002f8e
Microtus ochrogaster	101993745	79684_0:003230
Chinchilla lanigera	102021098	34839_0:002ca5		CHILA14686
Capra hircus	102179712			CAPHI20485
Vicugna pacos	102542222			VICPA00174
Peromyscus maniculatus bairdii	102903881	230844_0:003abb
Chlorocebus sabaeus	103217691			CHLSB01545
Carlito syrichta	103276881			CARSF01117

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Last updated: August 19, 2024