GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Proteomics identification
Reference proteome
Secreted
Signal
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q6IBE6
Q11206	Alpha 2,3-sialyltransferase IV Gal-NAc6S Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase N-acetyllactosaminide alpha-2,3-sialyltransferase SAT-3 ST-4 ST3Gal IV ST3GalA.2 STZ Sialyltransferase 4C
A0A7P0RGI5
A0A7I2V5F3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
positive regulation of leukocyte tethering or rolling	IMP	25498912
oligosaccharide biosynthetic process	IDA TAS	8288606
positive regulation of blood coagulation	ISS
lipid glycosylation	IDA	8288606
protein sialylation	IDA	8288606

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

O-glycan processing

protein sialylation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

O-glycan processing

protein sialylation

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation [inference]

O-glycan processing

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

O-glycan processing

protein sialylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

O-glycan processing

protein sialylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation [inference]

O-glycan processing

sialylation

protein sialylation

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

mucopolysaccharide metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation [inference]

O-glycan processing

protein sialylation

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

sulfur compound metabolic process [inference]

keratan sulfate metabolic process [inference]

keratan sulfate biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

keratan sulfate biosynthetic process

glycoprotein biosynthetic process

sulfur compound biosynthetic process [inference]

keratan sulfate biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

viral process [inference]

viral protein processing

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte adhesion to vascular endothelial cell [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
membrane	HDA	19946888
Golgi cisterna membrane	IEA
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane

organelle membrane [inference]

Golgi cisterna membrane

bounding membrane of organelle [inference]

Golgi membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	IBA IDA	8288606
N-acetyllactosaminide alpha-2,3-sialyltransferase activity	IDA IMP	25498912 8611500
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IBA IDA TAS	8288606
sialyltransferase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000110080

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg051

Gene Symbol

ST3GAL4

Reactions

Displaying **all 2** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G00031MO	G65562ZE	8288606
CMP-Neu5Ac	G58896AZ		8288606

Displaying **all 5** entries
Donor	Acceptor	Product	Reference
CMP-Neu5Ac	G00055MO		8288606
CMP-Neu5Ac	G58896AZ		8288606
CMP-Neu5Ac	G84224TW	G91237TK	8288606
CMP-Neu5Ac	G00031MO	G65562ZE	8288606
CMP-Neu5Ac	G64973KT	G11457RF

Displaying **all 4** entries
Donor	Acceptor	Reference
CMP-Neu5Ac	G72002FC	8288606
CMP-Neu5Ac	G00056MO	8288606
CMP-Neu5Ac	G26123AX	8288606
CMP-Neu5Ac	G00049MO	8288606

Orthologous Gene

Displaying **all 2** entries
Species	Protein	mRNA
Rattus norvegicus	NP_976082	NM_203337
Mus musculus	NP_033204	NM_009178

KEGG BRITE Database

Orthology

K03494

Name

beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4C) [EC:2.4.3.2 2.4.3.4 2.4.3.6]

References

8288606

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06153	2.4.3.6	G00049MO	G79536OW

Rhea

RHEA:21616

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.4

PMID

RHEA:18913

a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + a neolactoside IV³-α-NeuAc-nLc4Cer(d18:1(4E)) + CMP

Enzyme

2.4.3.6

PMID

7130178

RHEA:52380

a β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.2

PMID

RHEA:52316

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.6

PMID

RHEA:18021

CMP-N-acetyl-β-neuraminate + a ganglioside GM1 (d18:1(4E))

H⁺ + CMP + a ganglioside GD1a (d18:1(4E))

Enzyme

2.4.3.2

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **179** in total

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DO ID	Disease Name	Source
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050463	campomelic dysplasia	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050782	Zollinger-Ellison syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060307	autosomal dominant intellectual developmental disorder	DisGeNET
DOID:0060672	Grn-related frontotemporal lobar degeneration with Tdp43 inclusions	DisGeNET
DOID:0070034	autosomal dominant intellectual developmental disorder 4	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001000
Gene Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Ortholog

Displaying entries **21 - 30** of 74 in total

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Species	Gene ID	Orthologous MAtrix
Macaca nemestrina	105476232	MACNE14601
Mandrillus leucophaeus	105554687	MANLE33297
Gorilla gorilla gorilla	101141340	GORGO02533
Pan paniscus	100973080	PANPA08287
Pan troglodytes	466845	PANTR04703
Pongo abelii	100172032	PONAB04108
Canis lupus familiaris	607094	CANLF15096
Ursus americanus	123792732	URSAM03262
Mustela putorius furo	101671100	MUSPF14654
Panthera leo	122201083	PANLE14461

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements