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solute carrier family 2 member 1

Summary

Gene Symbol

SLC2A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6513

PubChem

6513

Alliance of Genome Resources

HGNC:11005

Annotation

Keyword

3D-structure
Acetylation
Cataract
Cell membrane
Direct protein sequencing
Disease variant
Dystonia
Epilepsy
Glycoprotein
Hereditary hemolytic anemia
Intellectual disability
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q59GX2	Glucose transporter type 1, erythrocyte/brain
P11166	Glucose transporter type 1, erythrocyte/brain HepG2 glucose transporter

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 25 in total

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GO Term	Evidence Code	PMID
transport across blood-brain barrier	IMP	1714544 28993322
transport across blood-brain barrier	IGI	23975336
response to Thyroglobulin triiodothyronine	IEA
glucose transmembrane transport	IDA	1429721 18245775 2211693 25982116 27078104
glucose transmembrane transport	IMP	21791420 23280796

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

organic cyclic compound metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process

heterocycle metabolic process [inference]

lactone metabolic process [inference]

L-ascorbic acid metabolic process

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

photoreceptor cell maintenance

developmental process [inference]

anatomical structure development [inference]

cerebral cortex development

system development [inference]

central nervous system development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response [inference]

cellular hyperosmotic response

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to Thyroglobulin triiodothyronine

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular response to osmotic stress [inference]

cellular hyperosmotic response

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

import across plasma membrane [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic substance transport [inference]

lipid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

lipid import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fucose transmembrane transport

hexose import across plasma membrane [inference]

glucose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

dehydroascorbic acid transport

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport [inference]

long-chain fatty acid transport [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import across plasma membrane

import into cell [inference]

long-chain fatty acid import into cell [inference]

long-chain fatty acid import across plasma membrane

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

glucose import across plasma membrane

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
female germ cell nucleus	IEA
photoreceptor inner segment	IEA
female pronucleus	IEA
cytosol	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

glucose transporter complex

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

Z disc

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

midbody

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus [inference]

germ cell nucleus [inference]

female germ cell nucleus

pronucleus [inference]

female pronucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

cortical cytoskeleton [inference]

cortical actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
dehydroascorbic acid transmembrane transporter activity	EXP	10862609 9228080
identical protein binding	IPI	1429721
xenobiotic transmembrane transporter activity	IEA
D-glucose transmembrane transporter activity	TAS
D-glucose transmembrane transporter activity	IDA	18245775 2211693 25982116 27078104

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

long-chain fatty acid transporter activity

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

fucose transmembrane transporter activity

xenobiotic transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

solute carrier family 2 (facilitated glucose

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hexose transmembrane transporter activity

Displaying **all 6** entries
InterPro
Glucose transporter GLUT
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Sugar transporter, conserved site
Sugar/inositol transporter

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0060326	myelomeningocele	Alliance of Genome Resources
DOID:0070560	glucose transporter type 1 deficiency syndrome	Alliance of Genome Resources
DOID:0070561	glucose transporter type 1 deficiency syndrome 1	Alliance of Genome Resources
DOID:0090044	dystonia 9	Alliance of Genome Resources
DOID:0090045	glucose transporter type 1 deficiency syndrome 2	Alliance of Genome Resources
DOID:0111313	obsolete idiopathic generalized epilepsy 12	Alliance of Genome Resources
DOID:1825	childhood absence epilepsy	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **117** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6513	Xenbase:XB-GENE-5755357
Saccharomyces cerevisiae S288C	6514	SGD:S000000445
Saccharomyces cerevisiae S288C	6515	SGD:S000000445
Saccharomyces cerevisiae S288C	6517	SGD:S000003072
Saccharomyces cerevisiae S288C	6518	SGD:S000003072
Mus musculus	20525	Xenbase:XB-GENE-5755357	MOUSE41470
Saccharomyces cerevisiae S288C	20526	SGD:S000000445
Saccharomyces cerevisiae S288C	20527	SGD:S000000445
Saccharomyces cerevisiae S288C	20528	SGD:S000003072
Rattus norvegicus	24778	Xenbase:XB-GENE-5755357	RATNO33193

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements