surfactant protein A1

Summary
Gene Symbol
  • SFTPA1
Aliases
  • COLEC4
  • SP-A
  • SP-A1
  • surfactant, pulmonary-associated protein A1A
Organism
Homo sapiens (human)
External Links
NCBI Gene
653509
HGNC
10798
KEGG Gene ID
hsa:653509
PubChem
653509
Alliance of Genome Resources
Annotation
Keyword
  • Acetylation
  • Alternative splicing
  • Calcium
  • Collagen
  • Disease variant
  • Disulfide bond
  • Extracellular matrix
  • Glycoprotein
  • Hydroxylation
  • Lectin
  • Reference proteome
  • Signal
  • Surface film
Proteins
Displaying all 2 entries
UniProt Protein Name
Q8IWL2
  • 35 kDa pulmonary surfactant-associated protein
  • Alveolar proteinosis protein
  • Collectin-4
B4DNP6
Gene Ontology (GO)
Displaying entries 1 - 5 of 7 in total
GO Term Evidence Code PMID
lamellar body
collagen trimer
extracellular region
endoplasmic reticulum membrane
multivesicular body
GO Hierarchy
Human Protein Atlas
ENSG00000122852

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K10067
Name
pulmonary surfactant-associated protein A
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 134 in total
DO ID Disease Name Source
DOID:0040085 bacterial sepsis
DOID:0050127 sinusitis
DOID:0050156 idiopathic pulmonary fibrosis
DOID:0050157 cryptogenic organizing pneumonia
DOID:0050445 X-linked dominant hypophosphatemic rickets
DOID:0050589 inflammatory bowel disease
DOID:0050782 Zollinger-Ellison syndrome
DOID:0050865 tongue squamous cell carcinoma
DOID:0050908 myelodysplastic syndrome
DOID:0060311 adenoid hypertrophy
The Human Phenotype Ontology
Displaying entries 1 - 10 of 18 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0001063 Acrocyanosis
HP:0001217 Clubbing
HP:0002020 Gastroesophageal reflux
HP:0002091 Restrictive ventilatory defect
HP:0002094 Dyspnea
HP:0002110 Bronchiectasis
HP:0002206 Pulmonary fibrosis
HP:0002875 Exertional dyspnea
HP:0003546 Exercise intolerance
Displaying all 2 entries
Disease ID Disease Name
OMIM:619611
  • interstitial lung disease 1
ORPHA:2032
  • interstitial lung disease 2

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024