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piezo-type mechanosensitive ion channel component 2

Summary

Gene Symbol

Piezo2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

667742

PubChem

667742

Alliance of Genome Resources

MGI:1918781

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Coiled coil
Disulfide bond
Glycoprotein
Ion channel
Phosphoprotein
Proteomics identification
Reference proteome
Sensory transduction
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
S4R2S0
E9QNW4
Q8CD54	Protein FAM38B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
monoatomic cation transport	IMP	20813920
response to mechanical stimulus	IDA	38568807
response to mechanical stimulus	IMP	24717433
regulation of membrane potential	IDA	20813920
regulation of membrane potential	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus

detection of mechanical stimulus

detection of mechanical stimulus involved in sensory perception

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus

detection of mechanical stimulus involved in sensory perception

response to mechanical stimulus

detection of mechanical stimulus

detection of mechanical stimulus involved in sensory perception

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus

detection of mechanical stimulus involved in sensory perception

detection of abiotic stimulus [inference]

detection of mechanical stimulus

detection of mechanical stimulus involved in sensory perception

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

monoatomic cation transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IC	20813920
plasma membrane	IBA
stereocilium	IDA	38228630
cuticular plate	IDA	38228630
neuronal cell body membrane	IDA	38568807

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cuticular plate

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

cell body membrane [inference]

neuronal cell body membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
monoatomic cation channel activity	IDA	20813920
monoatomic cation channel activity	IBA
protein binding	IPI	24662763 38228630 38568807
mechanosensitive monoatomic ion channel activity	IDA	20813920 31435011
mechanosensitive monoatomic ion channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

mechanosensitive monoatomic cation channel activity

mechanosensitive monoatomic ion channel activity

mechanosensitive monoatomic cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

mechanosensitive monoatomic cation channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity

mechanosensitive monoatomic cation channel activity

mechanosensitive monoatomic ion channel activity

mechanosensitive monoatomic cation channel activity

gated channel activity [inference]

mechanosensitive monoatomic ion channel activity

mechanosensitive monoatomic cation channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Piezo-type mechanosensitive ion channel component

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Piezo family
Piezo non-specific cation channel, R-Ras-binding domain

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9780	FB:FBgn0264953
Homo sapiens	63895	HGNC:26270	HUMAN37626
Homo sapiens	182492	HGNC:26270
Drosophila melanogaster	234839	FB:FBgn0264953
Rattus norvegicus	307380		RATNO13779
Drosophila melanogaster	361430	FB:FBgn0264953
Pan troglodytes	455495		PANTR15854
Canis lupus familiaris	490554		CANLF17653
Homo sapiens	667742	HGNC:26270
Monodelphis domestica	100017409		MONDO18909