Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / OrganismsTools
SugarDrawer
GlycanBuilder
Glycan Converters
GlycoMaple
GlycomeAtlas
LM-GlycomeAtlas
GALAXY
MCAW
GlycoSim
GRable
Guidelines
MIRAGE
toll like receptor 4
Summary
- Gene Symbol
-
- TLR4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Cell membrane
- Cell projection
- Direct protein sequencing
- Disulfide bond
- Endosome
- Glycoprotein
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- NAD
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O00206 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of extrinsic apoptotic signaling pathway |
GO Hierarchy
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of cellular response to macrophage colony-stimulating factor stimulus
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of cellular response to macrophage colony-stimulating factor stimulus
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
biological process
immune system process [inference]
metabolic process [inference]
cellular process [inference]
multicellular organismal process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
positive regulation of immune response [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
positive regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of immune response [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
positive regulation of response to biotic stimulus [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to external stimulus [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
positive regulation of immune response [inference]
regulation of response to cytokine stimulus [inference]
regulation of response to stress [inference]
regulation of defense response [inference]
positive regulation of defense response [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| lipopolysaccharide binding | ||
| lipopolysaccharide binding | ||
| lipopolysaccharide binding | ||
| amyloid-beta binding | ||
| lipopolysaccharide immune receptor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Toll-like receptor
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| immune response |
| immune system process |
| inflammatory response |
| toll-like receptor signaling pathway |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:3042 | allergic contact dermatitis | |
| DOID:3083 | chronic obstructive pulmonary disease | |
| DOID:3310 | atopic dermatitis | |
| DOID:3393 | coronary artery disease | |
| DOID:3407 | carotid artery disease | |
| DOID:4448 | macular degeneration | |
| DOID:4481 | allergic rhinitis | |
| DOID:4677 | keratitis | |
| DOID:5844 | myocardial infarction | |
| DOID:684 | hepatocellular carcinoma |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 7099 | ZFIN:ZDB-GENE-040219-9 | ||
| 7100 | FB:FBgn0026760 | ||
| 21897 | FB:FBgn0262473 | ||
| 21898 | ZFIN:ZDB-GENE-040219-9 | MOUSE40157 | |
| 21899 | FB:FBgn0262473 | ||
| 24088 | FB:FBgn0262473 | ||
| 29260 | ZFIN:ZDB-GENE-040219-9 | RATNO33665 | |
| 43222 | ZFIN:ZDB-GENE-090507-2 | ||
| 53791 | FB:FBgn0026760 | ||
| 239081 | FB:FBgn0026760 |
