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nei endonuclease VIII-like 1 (E. coli)

Summary

Gene Symbol

Neil1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72774

PubChem

72774

Alliance of Genome Resources

MGI:1920024

Annotation

Keyword

Alternative splicing
Chromosome
Cytoskeleton
DNA repair
DNA-binding
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8K4Q6	DNA glycosylase/AP lyase Neil1 DNA-(apurinic or apyrimidinic site) lyase Neil1 Endonuclease VIII-like 1 Nei homolog 1 Nei-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
negative regulation of nuclease activity	IEA ISO
base-excision repair	IBA IEA ISO
DNA repair	IDA	12200441
response to oxidative stress	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of macromolecule metabolic process [inference]

regulation of nuclease activity [inference]

negative regulation of nuclease activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

regulation of hydrolase activity [inference]

regulation of nuclease activity [inference]

negative regulation of nuclease activity

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IEA ISO
nucleus	IBA IDA ISO	12200441
centrosome	IEA
cytoplasm	IEA ISO
chromosome	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
zinc ion binding	IEA
lyase activity	IDA	12200441
DNA N-glycosylase activity	IBA IDA	12200441
hydrolase activity, acting on glycosyl bonds	ISO
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

endonuclease 8-like 1

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
L: Replication, recombination and repair

Displaying entries **1 - 10** of 12 in total

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Gene Ontology
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA repair
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair
catalytic activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
damaged DNA binding
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
hydrolase activity

Displaying **all 5** entries
InterPro
DNA glycosylase/AP lyase, H2TH DNA-binding
Endonuclease VIII-like 1, DNA binding
Formamidopyrimidine-DNA glycosylase, catalytic domain
MutM-like, N-terminal
Small ribosomal subunit protein uS13-like, H2TH

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060611	abdominal obesity-metabolic syndrome	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 97** of 97 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Phodopus roborovskii	127231792	109678_0:0036e1
Apodemus sylvaticus	127689017	10129_0:0025bc
Peromyscus californicus insignis	128124595	564181_0:00056f
Psammomys obesus	129687514	48139_1:003350
Chionomys nivalis	130873040	269649_0:00169c
Peromyscus eremicus	131914329	42410_0:00269b
Peromyscus eremicus	131914335	42410_0:002868

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024