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zona pellucida glycoprotein 2

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

81828

PubChem

81828

Alliance of Genome Resources

RGD:620605

Annotation

Keyword

Cell membrane
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Extracellular matrix
Fertilization
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O54767	Zona pellucida glycoprotein 2 Zona pellucida protein A

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
humoral immune response mediated by circulating immunoglobulin	ISO
binding of sperm to zona pellucida	ISS	22472438
binding of sperm to zona pellucida	ISO
binding of sperm to zona pellucida	IBA
binding of sperm to zona pellucida	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

reproductive process [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

prevention of polyspermy

response to stimulus [inference]

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response [inference]

humoral immune response mediated by circulating immunoglobulin

humoral immune response [inference]

humoral immune response mediated by circulating immunoglobulin

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

regulation of reproductive process [inference]

regulation of acrosome reaction

regulation of fertilization [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
multivesicular body	ISS
multivesicular body	ISO
multivesicular body	IEA
endoplasmic reticulum	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

intracellular anatomical structure [inference]

inclusion body

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

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GO Term	Evidence Code	PMID
acrosin binding	ISO
acrosin binding	IBA
acrosin binding	IEA
structural constituent of egg coat	ISS
structural constituent of egg coat	ISO

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

structural constituent of egg coat

binding [inference]

protein binding [inference]

enzyme binding [inference]

acrosin binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

latent-transforming growth factor beta-binding

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7783	Xenbase:XB-GENE-976172	HUMAN27129
Mus musculus	22787	Xenbase:XB-GENE-976172	MOUSE56139
Xenopus tropicalis	81828	Xenbase:XB-GENE-976172
Sus scrofa	396846		PIGXX20795
Xenopus tropicalis	398089	Xenbase:XB-GENE-976172
Canis lupus familiaris	403988		CANLF16504
Pan troglodytes	453979		PANTR11912
Felis catus	493977		FELCA34971
Macaca mulatta	697458		MACMU27418
Oryctolagus cuniculus	100009069		RABIT11202

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Acknowledgements