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Hsp70 family chaperone LHS1

Summary

Gene Symbol

LHS1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853789

PubChem

853789

Alliance of Genome Resources

SGD:S000001556

Annotation

Keyword

ATP-binding
Chaperone
Endoplasmic reticulum
Glycoprotein
Hydrolase
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P36016

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chromatin remodeling	IEA
protein folding	IEA
response to unfolded protein	IMP	8654361 8887673
post-translational protein targeting to membrane, translocation	IMP	8654361 8887673
chromatin looping	IEA

GO Hierarchy

biological process

cellular process [inference]

protein folding

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

transmembrane transport [inference]

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

protein transmembrane transport [inference]

intracellular protein transmembrane transport [inference]

post-translational protein targeting to membrane, translocation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA
endoplasmic reticulum	HDA	26928762
endoplasmic reticulum lumen	IDA	8654361 8887673
endoplasmic reticulum lumen	IEA
endoplasmic reticulum chaperone complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

endoplasmic reticulum chaperone complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
adenyl-nucleotide exchange factor activity	IDA	14704430
adenyl-nucleotide exchange factor activity	IBA
DNA clamp loader activity	IEA
ATP binding	IDA	19759005
ATP binding	IMP	19759005

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

ATP-dependent histone chaperone activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

cohesin loader activity

binding [inference]

protein binding [inference]

unfolded protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl-nucleotide exchange factor activity

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

protein folding chaperone [inference]

ATP-dependent protein folding chaperone

molecular function regulator activity [inference]

ATPase regulator activity [inference]

adenyl-nucleotide exchange factor activity

molecular carrier activity [inference]

protein carrier chaperone [inference]

histone chaperone activity [inference]

H3-H4 histone complex chaperone activity [inference]

ATP-dependent H3-H4 histone complex chaperone activity

ATP-dependent histone chaperone activity [inference]

ATP-dependent activity [inference]

ATP-dependent activity, acting on DNA [inference]

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

ATP-dependent protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein heat shock protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
ATP-dependent protein folding chaperone
endoplasmic reticulum unfolded protein response
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
nucleotide binding

Displaying **all 4** entries
InterPro
ATPase, nucleotide binding domain
Heat shock protein 70 family
Heat shock protein 70kD, C-terminal domain superfamily
Heat shock protein 70kD, peptide-binding domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endoplasmic reticulum	PMID:26928762
endoplasmic reticulum lumen	PMID:8654361 PMID:8887673

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	10525	Xenbase:XB-GENE-921821
Xenopus tropicalis	12282	Xenbase:XB-GENE-921821
Xenopus tropicalis	174033	Xenbase:XB-GENE-921821
Xenopus tropicalis	181422	Xenbase:XB-GENE-921821
Xenopus tropicalis	192235	Xenbase:XB-GENE-921821
Xenopus tropicalis	853789	Xenbase:XB-GENE-921821