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fructose-bisphosphatase 2

Summary

Gene Symbol

FBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8789

HGNC

3607

KEGG Gene ID

hsa:8789

PubChem

8789

Alliance of Genome Resources

HGNC:3607

Annotation

Keyword

3D-structure
Allosteric enzyme
Calcium
Carbohydrate metabolism
Cell junction
Cytoplasm
Disease variant
Gluconeogenesis
Hydrolase
Leukodystrophy
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O00757	D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 Muscle FBPase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fructose metabolic process	IBA
sucrose biosynthetic process	IBA
fructose 6-phosphate metabolic process	IBA
fructose 1,6-bisphosphate metabolic process	IBA
gluconeogenesis	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

sucrose metabolic process [inference]

sucrose biosynthetic process

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

sucrose metabolic process [inference]

sucrose biosynthetic process

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organophosphate metabolic process [inference]

carbohydrate derivative metabolic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
anchoring junction	IEA
Z disc	IEA
cytosol	IBA IDA TAS
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Z disc

cell junction [inference]

anchoring junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding	IEA
protein binding	IPI	25416956 25910212 28514442 31515488 32296183 32814053
identical protein binding	IPI	25416956 31515488 32296183
fructose 1,6-bisphosphate 1-phosphatase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose 1,6-bisphosphate 1-phosphatase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K03841

Name

fructose-1,6-bisphosphatase I [EC:3.1.3.11]

References

7589895

Rhea

RHEA:11064

H₂O + β-D-fructose 1,6-bisphosphate

phosphate + β-D-fructose 6-phosphate

Enzyme

3.1.3.11

PMID

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:1115	sarcoma	DisGeNET DisGeNET
DOID:1206	Rett syndrome	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET
DOID:1700	X-linked ichthyosis	DisGeNET DisGeNET
DOID:4235	spindle cell sarcoma	DisGeNET
DOID:5517	stomach carcinoma	DisGeNET DisGeNET
DOID:6193	epithelioid sarcoma	DisGeNET

The Human Phenotype Ontology

Displaying **all 8** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000737	Irritability
HP:0001288	Gait disturbance
HP:0002415	Leukodystrophy
HP:0002500	Abnormal cerebral white matter morphology
HP:0003593	Infantile onset
HP:0007359	Focal-onset seizure
HP:0011968	Feeding difficulties

Displaying 1 entry
Disease ID	Disease Name
OMIM:619864	leukodystrophy, childhood-onset, remitting

PubChem Disease

MedGen Diseases

Leukodystrophy, childhood-onset, remitting

OMIM Phenotypes

LEUKODYSTROPHY, CHILDHOOD-ONSET, REMITTING; CORLK

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **21 - 30** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Ailuropoda melanoleuca	100475474	AILME11675
Mustela putorius furo	101677003	MUSPF02723
Felis catus	101084578	FELCA29860
Panthera leo	122204921	PANLE25474
Balaenoptera musculus	118897362	BALMU13117
Loxodonta africana	100676689	LOXAF16894
Equus caballus	100061491	HORSE21988
Equus caballus	100063910	HORSE21988
Bos taurus	514066	BOVIN34903
Capra hircus	102185744	CAPHI29460

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Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements