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MIRAGE

fructose-bisphosphatase 2

Summary

Gene Symbol

FBP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8789

HGNC

3607

KEGG Gene ID

hsa:8789

PubChem

8789

Alliance of Genome Resources

HGNC:3607

Annotation

Keyword

3D-structure
Allosteric enzyme
Calcium
Carbohydrate metabolism
Cell junction
Cytoplasm
Disease variant
Gluconeogenesis
Hydrolase
Leukodystrophy
Magnesium
Metal-binding
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O00757	D-fructose-1,6-bisphosphate 1-phosphohydrolase 2 Muscle FBPase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sucrose biosynthetic process
fructose metabolic process	IBA
fructose 6-phosphate metabolic process	IBA
gluconeogenesis	IBA
gluconeogenesis	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

sucrose metabolic process [inference]

sucrose biosynthetic process

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

sucrose metabolic process [inference]

sucrose biosynthetic process

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organophosphate metabolic process [inference]

carbohydrate derivative metabolic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process [inference]

disaccharide biosynthetic process [inference]

sucrose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

organophosphate metabolic process [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IBA
cytosol	TAS
cytosol	IDA
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Z disc

cell junction [inference]

anchoring junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 25910212 28514442 31515488 32296183 32814053 33961781
fructose 1,6-bisphosphate 1-phosphatase activity	IBA
identical protein binding	IPI	25416956 31515488 32296183
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose 1,6-bisphosphate 1-phosphatase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fructose-1 6-bisphosphatase

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
fructose 1,6-bisphosphate 1-phosphatase activity
fructose 1,6-bisphosphate metabolic process
fructose 6-phosphate metabolic process
fructose metabolic process
gluconeogenesis
hydrolase activity
metal ion binding
phosphoric ester hydrolase activity
sucrose biosynthetic process

Displaying **all 5** entries
InterPro
Fructose-1,6-bisphosphatase class 1
Fructose-1,6-bisphosphatase, active site
Fructose-1,6-bisphosphatase
Fructose-1-6-bisphosphatase class 1, C-terminal
Fructose-1-6-bisphosphatase class I, N-terminal

KEGG BRITE Database

Orthology

K03841

Name

fructose-1,6-bisphosphatase I [EC:3.1.3.11]

References

7589895

Rhea

H₂O + β-D-fructose 1,6-bisphosphate

phosphate + β-D-fructose 6-phosphate

Enzyme

3.1.3.11

PMID

Disease

The Human Phenotype Ontology

Displaying **all 8** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000737	Irritability
HP:0001288	Gait disturbance
HP:0002415	Leukodystrophy
HP:0002500	Abnormal cerebral white matter morphology
HP:0003593	Infantile onset
HP:0007359	Focal-onset seizure
HP:0011968	Feeding difficulties

Displaying 1 entry
Disease ID	Disease Name
OMIM:619864	leukodystrophy, childhood-onset, remitting

PubChem Disease

MedGen Diseases

Leukodystrophy, childhood-onset, remitting

OMIM Phenotypes

LEUKODYSTROPHY, CHILDHOOD-ONSET, REMITTING; CORLK

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	2203	SGD:S000004369
Xenopus tropicalis	8789	Xenbase:XB-GENE-943524
Mus musculus	14120	Xenbase:XB-GENE-943524	MOUSE12210
Saccharomyces cerevisiae S288C	14121	SGD:S000004369
Saccharomyces cerevisiae S288C	24362	SGD:S000004369
Rattus norvegicus	114508	Xenbase:XB-GENE-943524	RATNO12451
Pan troglodytes	465261		PANTR44369
Canis lupus familiaris	476300		CANLF00378
Bos taurus	514066		BOVIN34903
Xenopus tropicalis	851092	Xenbase:XB-GENE-943524

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025