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MTSS I-BAR domain containing 1

Summary

Gene Symbol

MTSS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

9788

PubChem

9788

Alliance of Genome Resources

HGNC:20443

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Coiled coil
Cytoskeleton
Phosphoprotein
Reference proteome
Tumor suppressor

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O43312	Metastasis suppressor YGL-1 Metastasis suppressor protein 1 Missing in metastasis protein
A5YM41

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
plasma membrane organization	IEA
cell adhesion	NAS	12570871
transmembrane receptor protein tyrosine kinase signaling pathway	TAS	12570871
microspike assembly	NAS	12570871
actin cytoskeleton organization	TAS	12082544

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

epithelial cell proliferation involved in renal tubule morphogenesis

actin filament-based process [inference]

actin cytoskeleton organization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to fluid shear stress

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

microspike assembly

cell junction organization [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

cell-cell junction organization [inference]

adherens junction organization [inference]

adherens junction maintenance

cell-cell junction maintenance [inference]

adherens junction maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

membrane organization [inference]

plasma membrane organization

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

glomerulus morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to fluid shear stress

response to fluid shear stress [inference]

cellular response to fluid shear stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to fluid shear stress

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ruffle	NAS	12570871
cytoplasm	TAS	12570871
cytoplasmic side of plasma membrane	IBA
actin cytoskeleton	IDA	12570871
actin cytoskeleton	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

ruffle

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
actin binding	IBA
actin monomer binding	IDA	12570871
signaling receptor binding	IPI	12570871
protein binding	IPI	15383276 15688017
phospholipid binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

cytoskeletal protein binding [inference]

actin binding

actin monomer binding

identical protein binding

lipid binding [inference]

phospholipid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein MTSS 1 isoform 1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
actin binding
cell projection assembly
phospholipid binding
plasma membrane organization

Displaying **all 3** entries
InterPro
AH/BAR domain superfamily
I-BAR domain containing protein MTSS1/MTSS2
IMD/I-BAR domain

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	9788	Xenbase:XB-GENE-1013322
Drosophila melanogaster	92154	FB:FBgn0053558
Mus musculus	211401	Xenbase:XB-GENE-1013322	MOUSE15189
Drosophila melanogaster	244654	FB:FBgn0053558
Rattus norvegicus	362918		RATNO39283
Pan troglodytes	464381		PANTR43241
Canis lupus familiaris	482037		CANLF03206
Bos taurus	523498		BOVIN05746
Macaca mulatta	711465		MACMU43456
Monodelphis domestica	100032197		MONDO18667