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Mitogen-activated protein kinase kinase kinase 5

Summary

UniProt ID

O35099

Gene Symbol

Map3k5
Ask1
Mekk5

Organism

Mus musculus (house mouse)

External Links

GlyGen: O35099
PubChem: O35099
The O-GlcNAc Database: O35099
O-GlcNAcAtlas: O35099

Annotation

Keyword

ATP-binding
Apoptosis
Coiled coil
Cytoplasm
Endoplasmic reticulum
Innate immunity
Magnesium
Metal-binding
Methylation
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Stress response
Ubl conjugation

Gene Ontology (GO)

Displaying entries **1 - 10** of 28 in total

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GO Term
positive regulation of protein phosphorylation
phosphorylation
innate immune response
positive regulation of cardiac muscle cell apoptotic process
positive regulation of apoptotic process
endothelial cell apoptotic process
cellular response to reactive nitrogen species
positive regulation of vascular associated smooth muscle cell proliferation
positive regulation of JNK cascade
positive regulation of DNA-templated transcription

Displaying **all 3** entries
GO Term
protein kinase complex
IRE1-TRAF2-ASK1 complex
external side of plasma membrane

Displaying **all 9** entries
GO Term
protein domain specific binding
protein homodimerization activity
magnesium ion binding
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
ATP binding
protein phosphatase binding
protein serine kinase activity
protein kinase binding

Annotation information from UniProt.

Sequence

MGTEAGEGITFSVPPFASVGFCTIPEGGSCRRGGGAATAAEGEPSLQPLLVPPPPPPPGSFWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEALQSLREACEAVGATLETLHFGKLDFGETAVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILSDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPSAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFGASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTITEEKGRGAEDGDCEGDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFLKVSSKKKKTQPKLSALSTGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKARAKSCGEKDGKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGAEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLDVEDEHEELSSNQTVRRPQAITEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKIETNRLLEELVRKERELQALLHQAIEEKDQEIRHLKLKSQPIDIPGFPVCHLNSPGTTTEDSELPGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites