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Mitogen-activated protein kinase kinase kinase 5

Summary

UniProt ID

O35099

Gene Symbol

Map3k5
Ask1
Mekk5

Organism

Mus musculus (house mouse)

External Links

GlyGen: O35099
PubChem: O35099
The O-GlcNAc Database: O35099
O-GlcNAcAtlas: O35099

Annotation

Keyword

ATP-binding
Apoptosis
Coiled coil
Cytoplasm
Endoplasmic reticulum
Innate immunity
Magnesium
Metal-binding
Methylation
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Stress response
Ubl conjugation

Gene Ontology (GO)

Displaying entries **11 - 20** of 28 in total

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GO Term
stress-activated MAPK cascade
intrinsic apoptotic signaling pathway in response to oxidative stress
response to endoplasmic reticulum stress
positive regulation of MAPK cascade
cellular response to amino acid starvation
neuron intrinsic apoptotic signaling pathway in response to oxidative stress
p38MAPK cascade
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to hydrogen peroxide
cellular response to tumor necrosis factor

Displaying **all 3** entries
GO Term
IRE1-TRAF2-ASK1 complex
external side of plasma membrane
protein kinase complex

Displaying **all 9** entries
GO Term
protein kinase binding
protein serine kinase activity
protein domain specific binding
protein homodimerization activity
magnesium ion binding
JUN kinase kinase kinase activity
MAP kinase kinase kinase activity
ATP binding
protein phosphatase binding

Annotation information from UniProt.

Sequence

MGTEAGEGITFSVPPFASVGFCTIPEGGSCRRGGGAATAAEGEPSLQPLLVPPPPPPPGSFWNVESAAAPGTSCPTTAPGSSATRGRGNSGSGGGRRTTVAYVINEASQGQLVVAESEALQSLREACEAVGATLETLHFGKLDFGETAVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKGLTELMQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRESILSDIRKARNLYTGKELAAELARIRQRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKLFRLKTPAWYLKSIVETILIYKHFVKLTTEQPSAKQELVDFWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFGASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTITEEKGRGAEDGDCEGDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFLKVSSKKKKTQPKLSALSTGSNEYLRSISLPVPVLVEDTSSSSEYGSVSPDTELKADPFSFKARAKSCGEKDGKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGAEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADPEDLDVEDEHEELSSNQTVRRPQAITEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKIETNRLLEELVRKERELQALLHQAIEEKDQEIRHLKLKSQPIDIPGFPVCHLNSPGTTTEDSELPGWLRENGADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites