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Standards Ontologies Notations
Guidelines
MIRAGE
Tumor necrosis factor

Summary
UniProt ID
P01375
Gene Symbol
  • TNF
  • TNFA
  • TNFSF2
Gene ID
7124
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P01375
PubChem
P01375
The Human Metabolome Database
HMDBP02070
Re-Glyco
P01375
Annotation
Keyword
  • 3D-structure
  • Cell membrane
  • Cytokine
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Myristate
  • Phosphoprotein
  • Reference proteome
  • Secreted
  • Signal-anchor
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 9 entries
GO Term
extracellular region
extracellular space
plasma membrane
phagocytic cup
neuronal cell body
external side of plasma membrane
cell surface
membrane raft
recycling endosome
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying 1 entry
Position Description PubMed ID GlyTouCan ID Source
80 O-linked (GalNAc...) serine; in soluble form
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 9 entries
Pathway Name Organism
Interleukin-10 signaling Homo sapiens
Interleukin-4 and Interleukin-13 signaling Homo sapiens
Regulation of TNFR1 signaling Homo sapiens
TNF signaling Homo sapiens
TNFR1-induced NF-kappa-B signaling pathway Homo sapiens
TNFR1-induced proapoptotic signaling Homo sapiens
TNFR1-mediated ceramide production Homo sapiens
TNFR2 non-canonical NF-kB pathway Homo sapiens
Transcriptional regulation of white adipocyte differentiation Homo sapiens
Disease
Displaying entries 11 - 20 of 83 in total
DO ID Disease Name Source
DOID:10591 pre-eclampsia
DOID:10652 Alzheimer's disease
DOID:1067 open-angle glaucoma
DOID:1070 primary open angle glaucoma
DOID:10763 hypertension
DOID:11265 trachoma
DOID:11394 adult respiratory distress syndrome
DOID:11650 bronchopulmonary dysplasia
DOID:11713 diabetic angiopathy
DOID:11758 iron deficiency anemia
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 4, 2025