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Standards Ontologies Notations
Receptor tyrosine-protein kinase erbB-2

Summary
UniProt ID
P04626
Gene Symbol
  • ERBB2
  • HER2
  • MLN19
  • NEU
  • NGL
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011368
GlyConnect
GlyGen
P04626
PubChem
P04626
The Human Metabolome Database
HMDBP01473
RaftProt
P04626
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Activator
  • Alternative initiation
  • Alternative splicing
  • Cell membrane
  • Cell projection
  • Chromosomal rearrangement
  • Cytoplasm
  • Disease variant
  • Disulfide bond
  • Endosome
  • Glycoprotein
  • Nucleus
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Signal
  • Transcription regulation
  • Transmembrane helix
  • Tyrosine-protein kinase
Gene Ontology (GO)
Displaying entry 41 - 41 of 41 in total
GO Term
transmembrane receptor protein tyrosine kinase signaling pathway
Displaying entry 11 - 11 of 11 in total
GO Term
ATP binding
Annotation information from UniProt.
Sequence
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 10 entries
Position Description PubMed ID GlyTouCan ID Source
68 N-linked (GlcNAc...) asparagine
124 N-linked (GlcNAc...) asparagine
127
187 N-linked (GlcNAc...) asparagine
259 N-linked (GlcNAc...) asparagine
526
530 N-linked (GlcNAc...) asparagine
571 N-linked (GlcNAc...) asparagine
629 N-linked (GlcNAc...) asparagine
998
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 30 in total
Pathway Name Organism
Constitutive Signaling by Aberrant PI3K in Cancer Homo sapiens
Constitutive Signaling by Overexpressed ERBB2 Homo sapiens
Downregulation of ERBB2 signaling Homo sapiens
Downregulation of ERBB2:ERBB3 signaling Homo sapiens
Drug resistance in ERBB2 TMD/JMD mutants Homo sapiens
Drug-mediated inhibition of ERBB2 signaling Homo sapiens
ERBB2 Activates PTK6 Signaling Homo sapiens
ERBB2 Regulates Cell Motility Homo sapiens
GRB2 events in ERBB2 signaling Homo sapiens
GRB7 events in ERBB2 signaling Homo sapiens
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024