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T-cell surface glycoprotein CD4

Summary

UniProt ID

P05540

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

GlyConnect

GlyGen

P05540

PubChem

P05540

Annotation

Keyword

3D-structure
Adaptive immunity
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 10** of 29 in total

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GO Term
helper T cell enhancement of adaptive immune response
positive regulation of viral entry into host cell
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of protein phosphorylation
positive regulation of calcium ion transport into cytosol
response to estradiol
positive regulation of canonical NF-kappaB signal transduction
positive regulation of MAPK cascade
positive regulation of calcium-mediated signaling
regulation of calcium ion transport

Displaying **all 6** entries
GO Term
endoplasmic reticulum lumen
endoplasmic reticulum membrane
external side of plasma membrane
cell surface
plasma membrane
membrane raft

Displaying entries **1 - 10** of 14 in total

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GO Term
interleukin-16 binding
interleukin-16 receptor activity
lipid binding
coreceptor activity
immunoglobulin binding
enzyme binding
protein kinase binding
identical protein binding
protein homodimerization activity
protein tyrosine kinase binding

Annotation information from UniProt.

Sequence

MCRGFSFRHLLPLLLLQLSKLLVVTQGKTVVLGKEGGSAELPCESTSRRSASFAWKSSDQKTILGYKNKLLIKGSLELYSRFDSRKNAWERGSFPLIINKLRMEDSQTYVCELENKKEEVELWVFRVTFNPGTRLLQGQSLTLILDSNPKVSDPPIECKHKSSNIVKDSKAFSTHSLRIQDSGIWNCTVTLNQKKHSFDMKLSVLGFASTSITAYKSEGESAEFSFPLNLGEESLQGELRWKAEKAPSSQSWITFSLKNQKVSVQKSTSNPKFQLSETLPLTLQIPQVSLQFAGSGNLTLTLDRGILYQEVNLVVMKVTQPDSNTLTCEVMGPTSPKMRLILKQENQEARVSRQEKVIQVQAPEAGVWQCLLSEGEEVKMDSKIQVLSKGLNQTMFLAVVLGSAFSFLVFTGLCILFCVRCRHQQRQAARMSQIKRLLSEKKTCQCSHRMQKSHNLI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
186	N-linked (GlcNAc...) asparagine	2113054		UniProt GlyGen
297	N-linked (GlcNAc...) asparagine	2113054		UniProt GlyGen
334				GlyGen
392	N-linked (GlcNAc...) asparagine			UniProt GlyGen
			G23863VK G78059CC G36191CD G50045TK G16828VN G72735IY G52064IJ G81295CK G08520NM G33609NS G39188ZX G80966KZ G39213VZ G06110VR G55220VL G60145BJ G88673AA G14669DU G22768VO	GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Alpha-defensins	Rattus norvegicus
Cargo recognition for clathrin-mediated endocytosis	Rattus norvegicus
Clathrin-mediated endocytosis	Rattus norvegicus
Downstream TCR signaling	Rattus norvegicus
Generation of second messenger molecules	Rattus norvegicus
Other interleukin signaling	Rattus norvegicus
PD-1 signaling	Rattus norvegicus
Phosphorylation of CD3 and TCR zeta chains	Rattus norvegicus
Translocation of ZAP-70 to Immunological synapse	Rattus norvegicus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements