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MIRAGE
Tyrosinase
Summary
- UniProt ID
- P11344
- Gene Symbol
-
- Tyr
- Gene ID
- 22173
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Albinism
- Copper
- Disease variant
- Glycoprotein
- Melanin biosynthesis
- Metal-binding
- Monooxygenase
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| melanosome membrane |
| membrane |
| melanosome |
| perinuclear region of cytoplasm |
| GO Term |
|---|
| thymus development |
| response to vitamin D |
| response to cAMP |
| melanin biosynthetic process |
| cell population proliferation |
| pigmentation |
| response to blue light |
| response to UV |
| GO Term |
|---|
| identical protein binding |
| protein homodimerization activity |
| tyrosinase activity |
| copper ion binding |
Sequence
MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGSPCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMNNGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLWEQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIICSRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDRTANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYSYLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKKQPQEERQPLLMDKDDYHSLLYQSHL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 86 | N-linked (GlcNAc...) asparagine |
|
||
| 111 | N-linked (GlcNAc...) asparagine |
|
||
| 161 | N-linked (GlcNAc...) asparagine |
|
||
| 230 | N-linked (GlcNAc...) asparagine |
|
||
| 337 | N-linked (GlcNAc...) asparagine |
|
||
| 371 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Melanin biosynthesis | Mus musculus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050632 | oculocutaneous albinism | |
| DOID:11211 | buphthalmos |
