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Repository for lectin-assisted multimodality data
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MIRAGE
Ras-related C3 botulinum toxin substrate 2
Summary
- UniProt ID
- P15153
- Gene Symbol
-
- RAC2
- Gene ID
- 5880
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- Acetylation
- Cytoplasm
- Direct protein sequencing
- Disease variant
- GTP-binding
- Glycoprotein
- Methylation
- Prenylation
- Reference proteome
- Gene Ontology (GO)
| GO Term |
|---|
| protein kinase regulator activity |
| GTPase activity |
| GTP binding |
Sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRACSLL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 17 |
|
|||
| 32 | O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 |
|
||
| 41 |
|
|||
| 182 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Constitutive Signaling by Aberrant PI3K in Cancer | Homo sapiens |
| GPVI-mediated activation cascade | Homo sapiens |
| PCP/CE pathway | Homo sapiens |
| PI3K/AKT Signaling | Homo sapiens |
| PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | Homo sapiens |
| RAC2 GTPase cycle | Homo sapiens |
| RHO GTPases Activate NADPH Oxidases | Homo sapiens |
| ROS and RNS production in phagocytes | Homo sapiens |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0112061 | immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia | |
| DOID:0112062 | immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia | |
| DOID:0112064 | immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis |
