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Transforming growth factor beta-1 proprotein

Summary

UniProt ID

P17246

Gene Symbol

Tgfb1

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: P17246

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Growth factor
Mitogen
Reference proteome
Signal

Gene Ontology (GO)

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GO Term
membrane protein intracellular domain proteolysis
regulation of cell growth
vasculogenesis
ureteric bud development
morphogenesis of a branching structure
cell activation
epithelial to mesenchymal transition
negative regulation of protein phosphorylation
regulation of sodium ion transport
chondrocyte differentiation

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GO Term
extracellular space
cytoplasm
microvillus
secretory granule
axon
extracellular matrix
collagen-containing extracellular matrix
neuronal cell body
cell surface
blood microparticle

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GO Term
identical protein binding
cytokine activity
antigen binding
type II transforming growth factor beta receptor binding
transforming growth factor beta receptor binding
growth factor activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding
deubiquitinase activator activity
enzyme binding

Annotation information from UniProt.

Sequence

MPPSGLRLLPLLLPLPWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESADPEPEPEADYYAKEVTRVLMVDRNNAIYDKTKDITHSIYMFFNTSDIREAVPEPPLLSRAELRLQRFKSTVEQHVELYQKYSNNSWRYLGNRLLTPTDTPEWLSFDVTGVVRQWLNQGDGIQGFRFSAHCSCDSKDNVLHVEINGISPKRRGDLGTIHDMNRPFLLLMATPLERAQHLHSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASASPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	Source
82	N-linked (GlcNAc...) asparagine	UniProt
136	N-linked (GlcNAc...) asparagine	UniProt
176	N-linked (GlcNAc...) asparagine	UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 10** entries
Pathway Name	Organism
Cell surface interactions at the vascular wall	Rattus norvegicus
Downregulation of TGF-beta receptor signaling	Rattus norvegicus
Molecules associated with elastic fibres	Rattus norvegicus
Platelet degranulation	Rattus norvegicus
RUNX3 regulates CDKN1A transcription	Rattus norvegicus
RUNX3 regulates p14-ARF	Rattus norvegicus
Regulation of RUNX3 expression and activity	Rattus norvegicus
Syndecan interactions	Rattus norvegicus
TGF-beta receptor signaling activates SMADs	Rattus norvegicus
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Rattus norvegicus