ATP-dependent 6-phosphofructokinase, liver type

Summary
UniProt ID
P17858
Gene Symbol
  • PFKL
Organism
Homo sapiens (human)
External Links
GlyConnect
GlyGen
P17858
PubChem
P17858
The Human Metabolome Database
HMDBP00758
The O-GlcNAc Database
P17858
RaftProt
P17858
O-GlcNAcAtlas
P17858
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Allosteric enzyme
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Glycolysis
  • Glycoprotein
  • Kinase
  • Magnesium
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
Gene Ontology (GO)
Sequence
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
Glycosylation Sites
Displaying all 3 entries
Position Description PubMed ID GlyTouCan ID Source
399
464
529 O-linked (GlcNAc) serine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 2 entries
Pathway Name Organism
Glycolysis Homo sapiens
Neutrophil degranulation Homo sapiens
Disease
Displaying entries 21 - 27 of 27 in total
DO ID Disease Name Source
DOID:3535 Unverricht-Lundborg syndrome
DOID:3571 liver cancer
DOID:6419 tetralogy of Fallot
DOID:684 hepatocellular carcinoma
DOID:891 progressive myoclonus epilepsy
DOID:9266 cystinuria
DOID:9870 galactosemia

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024