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Glycan Structure Repository
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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Syndecan-1
Summary
- UniProt ID
- P18827
- Gene Symbol
-
- SDC1
- SDC
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P18827
- PubChem
- P18827
- The Human Metabolome Database
- HMDBP02143
- The O-GlcNAc Database
- P18827
- O-GlcNAcAtlas
- P18827
Annotation
- Keyword
-
- 3D-structure
- Heparan sulfate
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| response to cAMP |
| canonical Wnt signaling pathway |
| receptor-mediated endocytosis |
| response to hydrogen peroxide |
| GO Term |
|---|
| plasma membrane |
| protein-containing complex |
| extracellular exosome |
| Golgi lumen |
| external side of plasma membrane |
| cell surface |
| lysosomal lumen |
| GO Term |
|---|
| cargo receptor activity |
| identical protein binding |
Sequence
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 37 | O-linked (Xyl...) (chondroitin sulfate) serine |
|
||
| 43 | N-linked (GlcNAc...) asparagine |
|
||
| 45 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 47 | O-linked (Xyl...) (heparan sulfate) serine |
|
||
| 58 |
|
|||
| 61 |
|
|||
| 63 |
|
|||
| 64 |
|
|||
| 72 |
|
|||
| 76 |
|
G57321FI
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | Homo sapiens |
| Attachment and Entry | Homo sapiens |
| Cell surface interactions at the vascular wall | Homo sapiens |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | Homo sapiens |
| Defective B3GAT3 causes JDSSDHD | Homo sapiens |
| Defective B4GALT7 causes EDS, progeroid type | Homo sapiens |
| Defective EXT1 causes exostoses 1, TRPS2 and CHDS | Homo sapiens |
| Defective EXT2 causes exostoses 2 | Homo sapiens |
| HS-GAG biosynthesis | Homo sapiens |
| HS-GAG degradation | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:576 | proteinuria | |
| DOID:5844 | myocardial infarction | |
| DOID:5854 | silent myocardial infarction | |
| DOID:6000 | congestive heart failure | |
| DOID:612 | primary immunodeficiency disease | |
| DOID:6245 | renal oncocytoma | |
| DOID:6263 | inflammatory breast carcinoma | |
| DOID:635 | acquired immunodeficiency syndrome | |
| DOID:640 | encephalomyelitis | |
| DOID:6457 | Cowden syndrome |
