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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Summary
- UniProt ID
- P19174
- Gene Symbol
-
- PLCG1
- PLC1
- Organism
- Homo sapiens (human)
External Links
- GlyGen
- P19174
- PubChem
- P19174
- The Human Metabolome Database
- HMDBP00244
- The O-GlcNAc Database
- P19174
- O-GlcNAcAtlas
- P19174
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Calcium
- Cell projection
- Disease variant
- Host-virus interaction
- Hydrolase
- Lipid degradation
- Metal-binding
- Phosphoprotein
- Reference proteome
- Repeat
- SH2 domain
- SH3 domain
- Transducer
- Ubl conjugation
- Gene Ontology (GO)
| GO Term |
|---|
| Schaffer collateral - CA1 synapse |
| glutamatergic synapse |
| lamellipodium |
| cytosol |
| ruffle |
| COP9 signalosome |
| ruffle membrane |
| cytoplasm |
| plasma membrane |
| cell-cell junction |
Sequence
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERRAPRRTRVNGDNRL
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 63 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NTRK2 signals through PLCG1 | Homo sapiens |
| Activated NTRK3 signals through PLCG1 | Homo sapiens |
| Constitutive Signaling by EGFRvIII | Homo sapiens |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants | Homo sapiens |
| DAG and IP3 signaling | Homo sapiens |
| DAP12 signaling | Homo sapiens |
| Downstream signal transduction | Homo sapiens |
| EGFR interacts with phospholipase C-gamma | Homo sapiens |
| Erythropoietin activates Phospholipase C gamma (PLCG) | Homo sapiens |
| FCERI mediated Ca+2 mobilization | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:14221 | abdominal obesity-metabolic syndrome 1 | |
| DOID:14261 | fragile X syndrome | |
| DOID:14262 | oral candidiasis | |
| DOID:1470 | major depressive disorder | |
| DOID:1508 | candidiasis | |
| DOID:1520 | colon carcinoma | |
| DOID:1555 | urticaria | |
| DOID:1558 | angioedema | |
| DOID:1595 | melancholic depression | |
| DOID:1596 | depressive disorder |
