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MIRAGE
Serum paraoxonase/arylesterase 1

Summary
UniProt ID
P27169
Gene Symbol
  • PON
  • PON1
Gene ID
5444
Organism
Homo sapiens (human)
GlycoProtDB
GPDB0011641
GlyConnect
GlyGen
P27169
PubChem
P27169
The Human Metabolome Database
HMDBP00091
The O-GlcNAc Database
P27169
RaftProt
P27169
O-GlcNAcAtlas
P27169
Re-Glyco
P27169
Annotation
Keyword
  • 3D-structure
  • Calcium
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • HDL
  • Hydrolase
  • Metal-binding
  • Reference proteome
  • Secreted
  • Signal
Gene Ontology (GO)
Displaying all 7 entries
GO Term
extracellular region
extracellular space
endoplasmic reticulum membrane
high-density lipoprotein particle
extracellular exosome
blood microparticle
spherical high-density lipoprotein particle
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
227
229
253 N-linked (GlcNAc...) asparagine
270 N-linked (GlcNAc...) asparagine
324 N-linked (GlcNAc...) asparagine
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying all 2 entries
Pathway Name Organism
Atorvastatin ADME Homo sapiens
Synthesis of 5-eicosatetraenoic acids Homo sapiens
Disease
Displaying entries 1 - 10 of 29 in total
DO ID Disease Name Source
DOID:0060060 non-Hodgkin lymphoma
DOID:0060669 cerebral cavernous malformation
DOID:1040 chronic lymphocytic leukemia
DOID:10603 glucose intolerance
DOID:10652 Alzheimer's disease
DOID:1067 open-angle glaucoma
DOID:1070 primary open angle glaucoma
DOID:10763 hypertension
DOID:10873 Kuhnt-Junius degeneration
DOID:11123 IgA vasculitis
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025