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Tyrosine-protein phosphatase non-receptor type 6

Summary

UniProt ID

P29351

Gene Symbol

Hcp
Hcph
Ptp1C
Ptpn6

Gene ID

15170

Organism

Mus musculus (house mouse)

External Links

GlyGen: P29351
PubChem: P29351
RaftProt: P29351
Re-Glyco: P29351

Annotation

Keyword

Alternative splicing
Cytoplasm
Direct protein sequencing
Disease variant
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome
Repeat
SH2 domain

Gene Ontology (GO)

Displaying **all 6** entries
GO Term
nucleolus
cytoplasm
cell-cell junction
alpha-beta T cell receptor complex
nucleoplasm
cytosol

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
platelet aggregation
negative regulation of humoral immune response mediated by circulating immunoglobulin
negative regulation of peptidyl-tyrosine phosphorylation
epididymis development
MAPK cascade
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
positive regulation of cell adhesion mediated by integrin
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway

Displaying **all 8** entries
GO Term
phosphotyrosine residue binding
protein tyrosine phosphatase activity
SH3 domain binding
protein kinase binding
SH2 domain binding
cell adhesion molecule binding
phosphorylation-dependent protein binding
transmembrane receptor protein tyrosine phosphatase activity

Annotation information from UniProt.

Sequence

MVRWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHISGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAGPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNSREHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQKGQESEYGNITYPPAVRSAHAKASRTSSKHKEEVYENVHSKSKKEEKVKKQRSADKEKNKGSLKRK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
101			G41840AI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Mus musculus
CD22 mediated BCR regulation	Mus musculus
Costimulation by the CD28 family	Mus musculus
GPVI-mediated activation cascade	Mus musculus
Interferon gamma signaling	Mus musculus
Interleukin receptor SHC signaling	Mus musculus
Interleukin-3, Interleukin-5 and GM-CSF signaling	Mus musculus
Neutrophil degranulation	Mus musculus
PD-1 signaling	Mus musculus
PECAM1 interactions	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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External Links

Annotation

International Collaboration

Acknowledgements