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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
E3 ubiquitin-protein ligase NEDD4
Summary
- UniProt ID
- P46935
- Gene Symbol
-
- Nedd4
- Kiaa0093
- Nedd-4
- Nedd4-1
- Nedd4a
- Rpf1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cytoplasm
- Isopeptide bond
- Neurogenesis
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- Transferase
- Ubl conjugation
- Ubl conjugation pathway
- Gene Ontology (GO)
| GO Term |
|---|
| protein K63-linked ubiquitination |
| regulation of postsynaptic neurotransmitter receptor internalization |
| neuromuscular junction development |
| adaptive immune response |
| GO Term |
|---|
| cytosol |
| nucleus |
| cytoplasm |
| plasma membrane |
| microvillus |
| membrane |
| postsynaptic cytosol |
| dendritic spine |
| glutamatergic synapse |
| ubiquitin ligase complex |
Sequence
MSSDMAADESEAPVLSEDEVWEFCLDKTEDGGGSPGSDVTDTCEPPCGCWELNPNSLEEEHVLFTADPYLELHNDDTRVVRVKVIAGIGLAKKDILGASDPYVRVTLYDPMSGILTSVQTKTIKKSLNPKWNEEILFRVLPQRHRILFEVFDENRLTRDDFLGQVDVPLYPLPTENPRMERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKNGSEDENADQAEELEPGWVVLDQPDAATHLPHPPEPSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPSPDDDLTDEDNDDMQLQAQRAFTTRRQISEDVDGPDNRESPENWEIVREDENTEYSGQAVQSPPSGHIDVQTHLAEEFNTRLAVCGNPATSQPVTSSNHSSRGGSLQTCIFEEQPTLPVLLPTSSGLPPGWEEKQDDRGRSYYVDHNSKTTTWSKPTMQDDPRSKIPAHLRGKTDSNDLGPLPPGWEERTHTDGRVFFINHNIKKTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRRKLKKQTDIPNKFEMKLRRANILEDSYRRIMGVKRADLLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLQKLITLHDMESVDSEYYSSLRWILENDPTELDLRFIIDEELFGQTHQHELKTGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSMNHQVIHWFWKAVWMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGTPDKLPRAHTCFNRLDLPPYESFDELWDKLQMAIENTQGFDGVD
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 370 |
|
|||
| 371 |
|
|||
| 375 |
|
|||
| 376 |
|
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Antigen processing: Ubiquitination & Proteasome degradation | Mus musculus |
| Downregulation of ERBB4 signaling | Mus musculus |
| ISG15 antiviral mechanism | Mus musculus |
| Regulation of PTEN localization | Mus musculus |
| Regulation of PTEN stability and activity | Mus musculus |
