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Nuclear receptor coactivator 2

Summary

UniProt ID

Q15596

Gene Symbol

BHLHE75
NCOA2
SRC2
TIF2

Gene ID

10499

Organism

Homo sapiens (human)

External Links

GlyGen: Q15596
PubChem: Q15596
The O-GlcNAc Database: Q15596
O-GlcNAcAtlas: Q15596
Re-Glyco: Q15596

Annotation

Keyword

3D-structure
Acetylation
Activator
Biological rhythms
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transcription regulation
Ubl conjugation

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
protein-containing complex
nucleoplasm
transcription regulator complex
chromatin
nucleus
cytoplasm
RNA polymerase II transcription regulator complex
nuclear body

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

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GO Term
cellular response to Thyroglobulin triiodothyronine
positive regulation of adipose tissue development
regulation of cellular response to insulin stimulus
regulation of glucose metabolic process
regulation of lipid metabolic process
regulation of DNA-templated transcription
locomotor rhythm
positive regulation of transcription by RNA polymerase II
negative regulation of transcription by RNA polymerase II
response to progesterone

Displaying **all 9** entries
GO Term
chromatin binding
transcription coactivator activity
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
nuclear receptor binding
protein domain specific binding
nuclear receptor coactivator activity
protein dimerization activity
aryl hydrocarbon receptor binding

Annotation information from UniProt.

Sequence

MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	GlyTouCan ID	Source
2	G49108TO	The O-GlcNAc Database
854		GlyGen
964	G49108TO	GlyGen The O-GlcNAc Database
1271	G59626AS G42124LM G46433HU	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying entries **1 - 10** of 20 in total

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Pathway Name	Organism
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Homo sapiens
Activation of gene expression by SREBF (SREBP)	Homo sapiens
BMAL1:CLOCK,NPAS2 activates circadian gene expression	Homo sapiens
Circadian Clock	Homo sapiens
Cytoprotection by HMOX1	Homo sapiens
Endogenous sterols	Homo sapiens
Estrogen-dependent gene expression	Homo sapiens
HATs acetylate histones	Homo sapiens
Heme signaling	Homo sapiens
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080199	colorectal carcinoma	Alliance of Genome Resources
DOID:2526	prostate adenocarcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements