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Polyphosphoinositide phosphatase

Summary

UniProt ID

Q92562

Gene Symbol

FIG4
KIAA0274
SAC3

Organism

Homo sapiens (human)

External Links

GlyGen: Q92562
PubChem: Q92562
The Human Metabolome Database: HMDBP14048
The O-GlcNAc Database: Q92562
O-GlcNAcAtlas: Q92562

Annotation

Keyword

3D-structure
Amyotrophic lateral sclerosis
Charcot-Marie-Tooth disease
Disease variant
Endosome
Hydrolase
Membrane
Reference proteome

Gene Ontology (GO)

Displaying **all 8** entries
GO Term
vacuole organization
locomotory behavior
neuron development
negative regulation of myelination
myelin assembly
pigmentation
phosphatidylinositol dephosphorylation
phosphatidylinositol biosynthetic process

Displaying **all 6** entries
GO Term
endosome membrane
lipid droplet
Golgi membrane
intracellular membrane-bounded organelle
early endosome membrane
late endosome membrane

Displaying **all 4** entries
GO Term
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
protein serine/threonine phosphatase activity

Annotation information from UniProt.

Sequence

MPTAAAPIISSVQKLVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTKMGQKGSSGLFRAVSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLIVKKFHKYEEEIDIHNEFFRPYELSSFDDTFCLAMTSSARDFMPKTVGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPVKMTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDFSIYSRFVQLGQSQHKQDKNSQQPCSRCSDGVIKLTPISAFSQDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDSSMYREYIRNRYL

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
724			G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Synthesis of PIPs at the Golgi membrane	Homo sapiens
Synthesis of PIPs at the early endosome membrane	Homo sapiens
Synthesis of PIPs at the late endosome membrane	Homo sapiens

Human Protein Atlas

ENSG00000112367

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Disease

Displaying entries **1 - 10** of **164** in total

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Last »
DO ID	Disease Name	Source
DOID:0050453	lissencephaly	DisGeNET
DOID:0050539	Charcot-Marie-Tooth disease type 2	DisGeNET DisGeNET DisGeNET
DOID:0050540	Charcot-Marie-Tooth disease type 3	DisGeNET
DOID:0050541	Charcot-Marie-Tooth disease type 4	DisGeNET
DOID:0050646	distal arthrogryposis	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050777	Joubert syndrome	DisGeNET
DOID:0060193	amyotrophic lateral sclerosis type 1	DisGeNET DisGeNET
DOID:0060194	amyotrophic lateral sclerosis type 2	DisGeNET
DOID:0060196	amyotrophic lateral sclerosis type 4	DisGeNET

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements