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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Protein smoothened
Summary
- UniProt ID
- Q99835
- Gene Symbol
-
- SMO
- SMOH
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cell projection
- Developmental protein
- Disease variant
- Disulfide bond
- G-protein coupled receptor
- Glycoprotein
- Phosphoprotein
- Reference proteome
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi apparatus |
| plasma membrane |
| cilium |
| intracellular membrane-bounded organelle |
| dendrite |
| endocytic vesicle membrane |
| ciliary membrane |
| extracellular exosome |
| endoplasmic reticulum |
| late endosome |
Sequence
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTELMDADSDF
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 35 | N-linked (GlcNAc...) asparagine | |||
| 47 |
|
|||
| 55 |
|
|||
| 188 | N-linked (GlcNAc...) asparagine | |||
| 309 | N-linked (GlcNAc...) asparagine |
|
||
| 446 |
|
|||
| 493 |
|
|||
| 500 |
|
|||
|
|
G08293MJ
G84452RH
G49108TO
G43417UB
G83460ZZ
G95995BI
G29068FM
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of SMO | Homo sapiens |
| BBSome-mediated cargo-targeting to cilium | Homo sapiens |
| Class B/2 (Secretin family receptors) | Homo sapiens |
| Hedgehog 'off' state | Homo sapiens |
| Hedgehog 'on' state | Homo sapiens |
