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Galectin-3

Summary

Lectin Name Aliases

Gal 3
Gal3
Galectin-3 (Human)
Human Galectin 3

Monosaccharide Specificities

Organism

Homo sapiens (human)

External Links

UniProt

P17931

LfDB

UniLectin

P17931

CarboGrove

1027
1028

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Differentiation
Disulfide bond
IgE-binding protein
Innate immunity
Lectin
Nucleus
Phosphoprotein
Reference proteome
Repeat
Secreted
Spliceosome

Gene Ontology (GO)

Displaying entries **1 - 10** of 24 in total

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GO Term
mRNA processing
negative regulation of T cell receptor signaling pathway
positive regulation of protein localization to plasma membrane
positive regulation of protein-containing complex assembly
eosinophil chemotaxis
macrophage chemotaxis
positive regulation of calcium ion import
regulation of T cell apoptotic process
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of protein tyrosine phosphatase activity

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GO Term
extracellular exosome
nucleoplasm
cytosol
cell surface
immunological synapse
spliceosomal complex
ficolin-1-rich granule membrane
extracellular region
extracellular space
nucleus

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GO Term
carbohydrate binding
laminin binding
RNA binding
IgE binding
protein phosphatase binding
signaling receptor inhibitor activity
protein phosphatase inhibitor activity
chemoattractant activity
molecular condensate scaffold activity
receptor ligand inhibitor activity

Annotation information from UniProt.

Reference

Displaying **all 3** entries
PubMed ID	Title	First Author
18849583	The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading.	Diskin S
24567334	Galectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion.	Jiang K
36504105	DC-SIGN and Galectin-3 individually and collaboratively regulate H5N1 and H7N9 avian influenza A virus infection via interaction with viral envelope hemagglutinin protein.	Yang ZS

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Advanced glycosylation endproduct receptor signaling	Homo sapiens
Neutrophil degranulation	Homo sapiens
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	Homo sapiens
RUNX2 regulates genes involved in differentiation of myeloid cells	Homo sapiens

Lectin Frontier DataBase (LfDB)

GlyTouCan: G92133LY
V-V₀: 591.09

GlyTouCan: G49017YR
V-V₀: 412.51

GlyTouCan: G92133LY
V-V₀: 270.85

LfDB provides quantitative interaction data in terms of the affinity constants (K_a) of a series of lectins toward a panel of pyridylaminated (PA) glycans obtained by an automated frontal affinity chromatography with fluorescence detection (FAC-FD) system. Since the data are accurate and reliable, providing the absolute values of sugar-protein interactions, LfDB would be a valuable resource in the studies of glycan-related biology.

The MCAW profile of the top three glycans above, which resulted from FAC analysis.

UniLectin

UniProt
P17931

CarboGrove

Lectin Name: Human Galectin 3
Common Name: Gal 3

Automated Analysis report (Top 10 high affinity glycans)

Array Source

CFG

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G25707UW	475.02	47.32
G80966KZ	171.77	12.62
G19687OL	141.02	28.48
G18988VX	134.12	17.87
G35382VN	127.58	26.24
G64586PM	114.89	18.6
G96881BQ	108.95	49.31
G06714AG	99.28	18.56
G13413XO	97.82	23.52
G42463OP	93.24	8.07

GlyTouCan ID	Binding Intensity	Stdev
G00720XU	48497.55	2540.45
G03577YK	47660.95	3585.49
G59122OR	46508.94	1609.01
G30694RX	45404.73	975.98
G73305LV	45403.96	893.05
G37796OS	43184.87	614.41
G80156FT	43160.71	1937.41
G19687OL	41443.08	424.54
G42463OP	40015	2177.78
G90130AG	38871.93	2554.28

GlyTouCan ID	Binding Intensity	Stdev
G30694RX	51432.79	2519.59
G00720XU	50744.81	2376.07
G80313NY	46751.58	1857.12
G91227VL	46542.07	1713.37
G20521BH	46539.98	1581.9
G18320HP	46458.23	2219.6
G73305LV	46248.92	2301.64
G59122OR	45723.14	1026.31
G97894QD	45642.88	2264.12
G80156FT	45598.3	1082.06

GlyTouCan ID	Binding Intensity	Stdev
G30694RX	59164.16	5319.24
G00720XU	58791.03	3408.91
G03577YK	56434.8	5890.81
G20521BH	55945.33	5608.94
G73305LV	55592.55	3504.07
G80156FT	52198.57	4384.31
G92140GK	50729.53	2784.2
G19026NP	47568.12	2323.75
G59122OR	47465.92	406.66
G90130AG	47007.94	3124.5

CarboGrove View

Array Source

GHMO

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G87373RB	137997.8	3821.58
G61710AG	103166	4768.88
G18059CR	94885.25	2665.39
G90411BS	77144	4872.74
G48059CD	66060	1309.97
G70995VB	63947.25	3214.2
G81578NL	62975	2137.26
G25956VZ	62660	5419.44
G63110FF	57352.5	722.08
G09415JG	53478.25	1724.05

GlyTouCan ID	Binding Intensity	Stdev
G94393CX	131039.3	7012.02
G18059CR	121608	12970.34
G87373RB	97398.25	8819.98
G61710AG	85850.25	3007.68
G63110FF	79632.75	2637.19
G90411BS	77773.75	4656.02
G96548CQ	71114	5992.62
G70995VB	70770.5	2570.55
G30622WV	66587.75	3051.96
G81578NL	65199	1254.99

GlyTouCan ID	Binding Intensity	Stdev
G18059CR	182590.5	12663.31
G70995VB	162734	12637.4
G87373RB	146038	18273.16
G61710AG	124920.8	2669.51
G94393CX	113626.5	4770.76
G63110FF	112730.3	5344.27
G96548CQ	111871.5	3502.73
G85278ER	111253	3202.61
G81578NL	106761.3	4468.95
G30622WV	90837.75	2695.13

GlyTouCan ID	Binding Intensity	Stdev
G18059CR	548656.31	55431.41
G94393CX	390289.5	44819.97
G96548CQ	372863.5	41180.01
G70995VB	335922.5	50130.15
G61710AG	309901.31	11707.73
G63110FF	306392.81	22482.02
G87373RB	299331.31	47236.97
G81578NL	234649.3	32191.74
G90411BS	222629.3	26016.32
G85278ER	222287.3	15390.16

CarboGrove View

CarboGrove is populated with the results from 35 types of glycan arrays, 13 glycan families, 5 experimental methods, and 19 laboratories or companies by processing and interpreting data from various types of glycan arrays.

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).