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Galectin-3

Summary

Lectin Name Aliases

Gal3
Galectin-3 (Human)

Monosaccharide Specificities

Organism

Homo sapiens (human)

External Links

UniProt

P17931

LfDB

UniLectin

P17931

CarboGrove

1027
1028

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Differentiation
Disulfide bond
IgE-binding protein
Innate immunity
Lectin
Nucleus
Phosphoprotein
Reference proteome
Repeat
Secreted
Spliceosome

Gene Ontology (GO)

Displaying entries **21 - 23** of 23 in total

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GO Term
negative regulation of protein tyrosine phosphatase activity
negative regulation of immunological synapse formation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Displaying entries **1 - 10** of 16 in total

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GO Term
nucleoplasm
cytosol
cell surface
extracellular region
extracellular space
nucleus
cytoplasm
mitochondrial inner membrane
plasma membrane
membrane

Displaying **all 9** entries
GO Term
carbohydrate binding
laminin binding
RNA binding
IgE binding
protein phosphatase binding
molecular condensate scaffold activity
protein phosphatase inhibitor activity
chemoattractant activity
disaccharide binding

Annotation information from UniProt.

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Advanced glycosylation endproduct receptor signaling	Homo sapiens
Neutrophil degranulation	Homo sapiens
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	Homo sapiens
RUNX2 regulates genes involved in differentiation of myeloid cells	Homo sapiens

Lectin Frontier DataBase (LfDB)

GlyTouCan: G92133LY
V-V₀: 591.09002685546875

GlyTouCan: G49017YR
V-V₀: 412.510986328125

GlyTouCan: G92133LY
V-V₀: 270.847991943359375

UniLectin

UniProt	PDB
P17931	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6F2Q 6F6Y 6FK2 6FOF 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6Y4C 7BE3 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX

UniProt

PDB

P17931

CarboGrove

Lectin Name: Human Galectin 3
Common Name: Gal 3

Automated Analysis report (Top 10 high affinity glycans)

Array Source

CFG

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G25707UW	475.0216064453125	47.3170013427734375
G80966KZ	171.7747039794921875	12.618300437927246094
G19687OL	141.023406982421875	28.479999542236328125
G18988VX	134.1208038330078125	17.870500564575195312
G35382VN	127.5791015625	26.242399215698242188
G64586PM	114.8852996826171875	18.60359954833984375
G96881BQ	108.95130157470703125	49.30699920654296875
G06714AG	99.27880096435546875	18.558599472045898438
G13413XO	97.8162994384765625	23.515199661254882812
G42463OP	93.2397003173828125	8.0719995498657226562

GlyTouCan ID	Binding Intensity	Stdev
G00720XU	48497.55078125	2540.4541015625
G03577YK	47660.94921875	3585.490966796875
G59122OR	46508.94140625	1609.012939453125
G30694RX	45404.73046875	975.97698974609375
G73305LV	45403.9609375	893.05059814453125
G37796OS	43184.87109375	614.41009521484375
G80156FT	43160.7109375	1937.406005859375
G19687OL	41443.078125	424.54180908203125
G42463OP	40015.0	2177.778076171875
G90130AG	38871.9296875	2554.282958984375

GlyTouCan ID	Binding Intensity	Stdev
G30694RX	51432.7890625	2519.587890625
G00720XU	50744.80859375	2376.074951171875
G80313NY	46751.578125	1857.1180419921875
G91227VL	46542.0703125	1713.3690185546875
G20521BH	46539.98046875	1581.904052734375
G18320HP	46458.23046875	2219.60400390625
G73305LV	46248.921875	2301.637939453125
G59122OR	45723.140625	1026.31494140625
G97894QD	45642.87890625	2264.118896484375
G80156FT	45598.30078125	1082.0579833984375

GlyTouCan ID	Binding Intensity	Stdev
G30694RX	59164.16015625	5319.2412109375
G00720XU	58791.03125	3408.9140625
G03577YK	56434.80078125	5890.80810546875
G20521BH	55945.328125	5608.93994140625
G73305LV	55592.55078125	3504.06689453125
G80156FT	52198.5703125	4384.31298828125
G92140GK	50729.53125	2784.2041015625
G19026NP	47568.12109375	2323.751953125
G59122OR	47465.921875	406.6636962890625
G90130AG	47007.94140625	3124.4970703125

CarboGrove View

Array Source

GHMO

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G87373RB	137997.796875	3821.58203125
G61710AG	103166.0	4768.8818359375
G18059CR	94885.25	2665.389892578125
G90411BS	77144.0	4872.73779296875
G48059CD	66060.0	1309.968017578125
G70995VB	63947.25	3214.197998046875
G81578NL	62975.0	2137.257080078125
G25956VZ	62660.0	5419.43603515625
G63110FF	57352.5	722.07501220703125
G09415JG	53478.25	1724.0469970703125

GlyTouCan ID	Binding Intensity	Stdev
G94393CX	131039.296875	7012.01611328125
G18059CR	121608.0	12970.33984375
G87373RB	97398.25	8819.9755859375
G61710AG	85850.25	3007.68408203125
G63110FF	79632.75	2637.18994140625
G90411BS	77773.75	4656.01611328125
G96548CQ	71114.0	5992.615234375
G70995VB	70770.5	2570.552001953125
G30622WV	66587.75	3051.955078125
G81578NL	65199.0	1254.988037109375

GlyTouCan ID	Binding Intensity	Stdev
G18059CR	182590.5	12663.3095703125
G70995VB	162734.0	12637.400390625
G87373RB	146038.0	18273.16015625
G61710AG	124920.796875	2669.511962890625
G94393CX	113626.5	4770.759765625
G63110FF	112730.296875	5344.26513671875
G96548CQ	111871.5	3502.72998046875
G85278ER	111253.0	3202.60693359375
G81578NL	106761.296875	4468.9541015625
G30622WV	90837.75	2695.1298828125

GlyTouCan ID	Binding Intensity	Stdev
G18059CR	548656.3125	55431.41015625
G94393CX	390289.5	44819.96875
G96548CQ	372863.5	41180.01171875
G70995VB	335922.5	50130.1484375
G61710AG	309901.3125	11707.73046875
G63110FF	306392.8125	22482.01953125
G87373RB	299331.3125	47236.96875
G81578NL	234649.296875	32191.740234375
G90411BS	222629.296875	26016.3203125
G85278ER	222287.296875	15390.16015625

CarboGrove View

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).