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Galectin-3

Summary

Lectin Name Aliases

Gal3
Galectin-3 (Human)

Monosaccharide Specificities

Organism

Homo sapiens (human)

External Links

UniProt

P17931

LfDB

UniLectin

P17931

CarboGrove

1027
1028

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Differentiation
Disulfide bond
IgE-binding protein
Innate immunity
Lectin
Nucleus
Phosphoprotein
Reference proteome
Repeat
Secreted
Spliceosome

Gene Ontology (GO)

Displaying entries **11 - 20** of 23 in total

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GO Term
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of protein tyrosine phosphatase activity
negative regulation of immunological synapse formation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
mRNA processing
RNA splicing
negative regulation of T cell receptor signaling pathway
positive regulation of protein localization to plasma membrane
positive regulation of protein-containing complex assembly
macrophage chemotaxis

Displaying entries **1 - 10** of 16 in total

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GO Term
nucleoplasm
cytosol
cell surface
extracellular region
extracellular space
nucleus
cytoplasm
mitochondrial inner membrane
plasma membrane
membrane

Displaying **all 9** entries
GO Term
carbohydrate binding
laminin binding
protein phosphatase inhibitor activity
disaccharide binding
RNA binding
IgE binding
protein phosphatase binding
molecular condensate scaffold activity
chemoattractant activity

Annotation information from UniProt.

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Advanced glycosylation endproduct receptor signaling	Homo sapiens
Neutrophil degranulation	Homo sapiens
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	Homo sapiens
RUNX2 regulates genes involved in differentiation of myeloid cells	Homo sapiens

Lectin Frontier DataBase (LfDB)

GlyTouCan: G92133LY
V-V₀: 591.09

GlyTouCan: G49017YR
V-V₀: 412.511

GlyTouCan: G92133LY
V-V₀: 270.848

UniLectin

UniProt	PDB
P17931	1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6F2Q 6F6Y 6FK2 6FOF 6I74 6I75 6I76 6I77 6I78 6KXA 6KXB 6Q0Q 6Q17 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM 6Y4C 7BE3 7RDO 7RDP 7RGX 7RGY 7RGZ 7RH0 7RH1 7RH3 7RH4 7XFA 7ZQX

UniProt

PDB

P17931

CarboGrove

Lectin Name: Human Galectin 3
Common Name: Gal 3

Automated Analysis report (Top 10 high affinity glycans)

Array Source

CFG

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G25707UW	475.022	47.317
G80966KZ	171.775	12.6183
G19687OL	141.023	28.48
G18988VX	134.121	17.8705
G35382VN	127.579	26.2424
G64586PM	114.885	18.6036
G96881BQ	108.951	49.307
G06714AG	99.2788	18.5586
G13413XO	97.8163	23.5152
G42463OP	93.2397	8.072

GlyTouCan ID	Binding Intensity	Stdev
G00720XU	48497.6	2540.45
G03577YK	47660.9	3585.49
G59122OR	46508.9	1609.01
G30694RX	45404.7	975.977
G73305LV	45404.0	893.051
G37796OS	43184.9	614.41
G80156FT	43160.7	1937.41
G19687OL	41443.1	424.542
G42463OP	40015.0	2177.78
G90130AG	38871.9	2554.28

GlyTouCan ID	Binding Intensity	Stdev
G30694RX	51432.8	2519.59
G00720XU	50744.8	2376.07
G80313NY	46751.6	1857.12
G91227VL	46542.1	1713.37
G20521BH	46540.0	1581.9
G18320HP	46458.2	2219.6
G73305LV	46248.9	2301.64
G59122OR	45723.1	1026.31
G97894QD	45642.9	2264.12
G80156FT	45598.3	1082.06

GlyTouCan ID	Binding Intensity	Stdev
G30694RX	59164.2	5319.24
G00720XU	58791.0	3408.91
G03577YK	56434.8	5890.81
G20521BH	55945.3	5608.94
G73305LV	55592.6	3504.07
G80156FT	52198.6	4384.31
G92140GK	50729.5	2784.2
G19026NP	47568.1	2323.75
G59122OR	47465.9	406.664
G90130AG	47007.9	3124.5

CarboGrove View

Array Source

GHMO

Protein Source

Investigator Provided

Concentration (ug/mL)

GlyTouCan ID	Binding Intensity	Stdev
G87373RB	137998.0	3821.58
G61710AG	103166.0	4768.88
G18059CR	94885.2	2665.39
G90411BS	77144.0	4872.74
G48059CD	66060.0	1309.97
G70995VB	63947.2	3214.2
G81578NL	62975.0	2137.26
G25956VZ	62660.0	5419.44
G63110FF	57352.5	722.075
G09415JG	53478.2	1724.05

GlyTouCan ID	Binding Intensity	Stdev
G94393CX	131039.0	7012.02
G18059CR	121608.0	12970.3
G87373RB	97398.2	8819.98
G61710AG	85850.2	3007.68
G63110FF	79632.8	2637.19
G90411BS	77773.8	4656.02
G96548CQ	71114.0	5992.62
G70995VB	70770.5	2570.55
G30622WV	66587.8	3051.96
G81578NL	65199.0	1254.99

GlyTouCan ID	Binding Intensity	Stdev
G18059CR	182590.0	12663.3
G70995VB	162734.0	12637.4
G87373RB	146038.0	18273.2
G61710AG	124921.0	2669.51
G94393CX	113626.0	4770.76
G63110FF	112730.0	5344.27
G96548CQ	111872.0	3502.73
G85278ER	111253.0	3202.61
G81578NL	106761.0	4468.95
G30622WV	90837.8	2695.13

GlyTouCan ID	Binding Intensity	Stdev
G18059CR	548656.0	55431.4
G94393CX	390290.0	44820.0
G96548CQ	372864.0	41180.0
G70995VB	335922.0	50130.1
G61710AG	309901.0	11707.7
G63110FF	306393.0	22482.0
G87373RB	299331.0	47237.0
G81578NL	234649.0	32191.7
G90411BS	222629.0	26016.3
G85278ER	222287.0	15390.2

CarboGrove View

MCAW-DB (Glycan Recognition Profile)

MCAW-DB is a database whereby users can view the multiple alignment analysis results obtained from the MCAW tool, which can computationally find common glycan substructures among a group of glycan structures. The data in MCAW-DB are analysis results of glycan array experiments; those glycans having higher binding affinity to glycan binding proteins (GBPs) have been analyzed and can be viewed as “glycan recognition profiles”. Currently, this database provides published analysis results of glycan array data from the Consortium for Functional Glycomics (CFG).