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Glycomics MS Repository for glycan annotations from GlycoWorkbench
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Repository for lectin-assisted multimodality data
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MIRAGE
CD209 antigen
Summary
- Lectin Name Aliases
-
- DC-SIGN
- LSECtin CRD Fc
- Monosaccharide Specificities
-
- Man
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative splicing
- Calcium
- Cell adhesion
- Cell membrane
- Disulfide bond
- Endocytosis
- Glycoprotein
- Host cell receptor for virus entry
- Host-virus interaction
- Innate immunity
- Mannose-binding
- Metal-binding
- Reference proteome
- Repeat
- Secreted
- Signal-anchor
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| host cell |
| external side of plasma membrane |
| cell surface |
| extracellular region |
| cytoplasm |
| plasma membrane |
| membrane |
| GO Term |
|---|
| mannose binding |
| carbohydrate binding |
| metal ion binding |
| virus receptor activity |
| peptide antigen binding |
| virion binding |
Reference
| PubMed ID | Title | First Author |
|---|---|---|
| 24108122 | Recognition of bisecting N-acetylglucosamine: structural basis for asymmetric interaction with the mouse lectin dendritic cell inhibitory receptor 2. | Nagae M |
| 27605665 | HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability. | Qian YW |
| 32817316 | Immunostimulation by Lactobacillus kefiri S-layer proteins with distinct glycosylation patterns requires different lectin partners. | Malamud M |
| 36504105 | DC-SIGN and Galectin-3 individually and collaboratively regulate H5N1 and H7N9 avian influenza A virus infection via interaction with viral envelope hemagglutinin protein. | Yang ZS |
| 17984090 | A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans. | Powlesland AS |
| 17150970 | Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins. | Feinberg H |
| 17339324 | The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. | Fuller GL |
| 17420244 | Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism. | Feinberg H |
| 19833723 | HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN). | Chung NP |
| 22645128 | Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers. | Depetris RS |
Pathway
| Pathway Name | Organism |
|---|---|
| Butyrophilin (BTN) family interactions | Homo sapiens |
| CD209 (DC-SIGN) signaling | Homo sapiens |
| RSV-host interactions | Homo sapiens |
UniLectin
| UniProt |
|---|
| Q9NNX6 |
CarboGrove
- Lectin Name
- DC-SIGN
- Common Name
- DC-SIGN
- Automated Analysis report (Top 10 high affinity glycans)
- Array Source
- Microbial
- Protein Source
- Investigator Provided
- Concentration (ug/mL)
-
G26425MP
G25559RS
G32046JJ
G48796BQ
G64541AU
G39023AU
G61491DK
G07682RX
G00052MO
G53402KW
G00051MO
