Common Pathway of Fibrin Clot Formation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
factor Xafactor Xa:Factor Xa inhibitorsFactor Xa inhibitors10xCbxE-F2FIIa10xCbxE-F2(44-327)F5F5(738-1573)factor VaVa:Xafactor XaVa:Xa:Factor Xa inhibitorsFibrinogenFGB(31-44)FGA(20-35)fibrin monomerfibrin multimerfactor XIIIfactor XIII cleaved tetramerF13A1(1-37)factor XIIIaF13BCa2+fibrin multimer, crosslinkedNH4+SERPINC1 activatorsSERPINC1:SERPINC1 activatorsAT3thrombin:SERPINC1:SERPINC1 activatorsthrombin:cleaved SERPINC1:SERPINC1 activatorsthrombin:cleaved SERPINC1activated thrombin:thrombomodulinTHBDEPCRPROCR:Protein CProtein CPROC(200-211)PROCR:Activated protein CActivated protein Cprotein SActivated protein C:Protein SF5(535-737)factor Vi intermediate formF5(335-534)factor Vifactor VIIIaF8(356-372)F8(582-640)Inactivated factor VIIISERPIND1activated thrombin (factor IIa):SERPIND1activated thrombin (factor IIa)SERPINE2:GAG:activated thrombin (factor IIa)SERPINE2:GAGSERPINA5:Activated protein CSERPINA5PROCR:Activated protein C:F2RF2R(42-425)PROCR(18-?):Activated protein CsEPCRPRTN3:CD177PROCR(18-?):PRTN3:CD177
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025