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NGF-stimulated transcription

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9031628

PubChem

R-HSA-9031628

Description

NGF stimulation induces expression of a wide array of transcriptional targets. In rat PC12 cells, a common model for NGF signaling, stimulation with NGF causes cells to exit the cell cycle and undergo a differentiation program leading to neurite outgrowth. This program is driven by the expression of immediate early genes (IEGs), which frequently encode transcription factors regulating the activity of NGF-specific delayed response genes (reviewed in Sheng and Greenberg, 1990; Flavell and Grennberg, 2008; Santiago and Bashaw, 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 27 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O15240	Neurosecretory protein VGF	VGF	view
P01100	Protein c-Fos	FOS G0S7	view
P11161	E3 SUMO-protein ligase EGR2	EGR2 KROX20	view
P11831	Serum response factor	SRF	view
P13726	Tissue factor	F3	view
P15336	Cyclic AMP-dependent transcription factor ATF-2	ATF2 CREB2 CREBP1	view
P15407	Fos-related antigen 1	FOSL1 FRA1	view
P17275	Transcription factor JunB	JUNB	view
P17535	Transcription factor JunD	JUND	view
P17752	Tryptophan 5-hydroxylase 1	TPH TPH1 TPRH TRPH	view

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