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E3 SUMO-protein ligase EGR2

Summary

UniProt ID

P11161

Gene Symbol

EGR2
KROX20

Gene ID

1959

Organism

Homo sapiens (human)

External Links

GlyGen: P11161
PubChem: P11161
The O-GlcNAc Database: P11161
O-GlcNAcAtlas: P11161
Re-Glyco: P11161

Annotation

Keyword

Acetylation
Activator
Alternative splicing
Charcot-Marie-Tooth disease
DNA-binding
Dejerine-Sottas syndrome
Disease variant
Neurodegeneration
Nucleus
Reference proteome
Repeat
Transcription regulation
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Gene Ontology (GO)

Displaying **all 5** entries
GO Term
chromatin
nucleus
cytoplasm
intracellular membrane-bounded organelle
nucleoplasm

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 27 in total

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GO Term
gene expression
peripheral nervous system development
learning or memory
rhythmic behavior
Schwann cell differentiation
positive regulation of Schwann cell differentiation
regulation of ossification
positive regulation of myelination
myelination
brain development

Displaying entries **1 - 10** of 13 in total

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GO Term
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
ubiquitin protein ligase binding
sequence-specific DNA binding
RNA polymerase II-specific DNA-binding transcription factor binding
transcription cis-regulatory region binding
SUMO ligase activity
sequence-specific double-stranded DNA binding

Annotation information from UniProt.

Sequence

MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 14 in total

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Position	GlyTouCan ID	Source
70	G49108TO	The O-GlcNAc Database
78	G49108TO G70994MS	GlyGen The O-GlcNAc Database
83	G49108TO	The O-GlcNAc Database
89	G49108TO	The O-GlcNAc Database
190	G49108TO	The O-GlcNAc Database
194	G49108TO	The O-GlcNAc Database
195	G49108TO	The O-GlcNAc Database
199	G49108TO	The O-GlcNAc Database
267	G49108TO	The O-GlcNAc Database
270	G13360UI	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Activation of anterior HOX genes in hindbrain development during early embryogenesis	Homo sapiens
EGR2 and SOX10-mediated initiation of Schwann cell myelination	Homo sapiens
NGF-stimulated transcription	Homo sapiens
Transcriptional regulation of white adipocyte differentiation	Homo sapiens

Disease

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050540	Charcot-Marie-Tooth disease type 3	Alliance of Genome Resources
DOID:0110150	Charcot-Marie-Tooth disease type 1D	Alliance of Genome Resources
DOID:0110195	Charcot-Marie-Tooth disease type 4E	Alliance of Genome Resources
DOID:2477	motor peripheral neuropathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements