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E3 SUMO-protein ligase EGR2

Summary

UniProt ID

P11161

Gene Symbol

EGR2
KROX20

Organism

Homo sapiens (human)

External Links

GlyGen: P11161
PubChem: P11161
The O-GlcNAc Database: P11161
O-GlcNAcAtlas: P11161

Annotation

Keyword

Acetylation
Activator
Alternative splicing
Charcot-Marie-Tooth disease
DNA-binding
Dejerine-Sottas syndrome
Disease variant
Neurodegeneration
Nucleus
Reference proteome
Repeat
Transcription regulation
Transferase
Ubl conjugation
Ubl conjugation pathway
Zinc-finger

Gene Ontology (GO)

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GO Term
brain development
peripheral nervous system development
learning or memory
gene expression
Schwann cell differentiation
positive regulation of Schwann cell differentiation
regulation of ossification
positive regulation of myelination
response to insulin
aorta development

Displaying **all 5** entries
GO Term
nucleoplasm
chromatin
nucleus
cytoplasm
intracellular membrane-bounded organelle

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GO Term
chromatin binding
metal ion binding
HMG box domain binding
RNA polymerase II-specific DNA-binding transcription factor binding
SUMO ligase activity
ubiquitin protein ligase binding
transcription cis-regulatory region binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity

Annotation information from UniProt.

Sequence

MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **11 - 14** of 14 in total

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Position	GlyTouCan ID	Source
289	G49108TO	GlyGen The O-GlcNAc Database
299	G49108TO	GlyGen The O-GlcNAc Database
382	G49108TO	GlyGen The O-GlcNAc Database
387	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Activation of anterior HOX genes in hindbrain development during early embryogenesis	Homo sapiens
EGR2 and SOX10-mediated initiation of Schwann cell myelination	Homo sapiens
NGF-stimulated transcription	Homo sapiens
Transcriptional regulation of white adipocyte differentiation	Homo sapiens