Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Displaying entries 1 - 10 of 18 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta
  • IKBKB
  • IKKB
view
O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha
  • CHUK
  • IKKA
  • TCF16
view
P00519 Tyrosine-protein kinase ABL1
  • ABL
  • ABL1
  • JTK7
view
P04632 Calpain small subunit 1
  • CAPN4
  • CAPNS
  • CAPNS1
view
P05106 Integrin beta-3
  • GP3A
  • ITGB3
view
P05556 Integrin beta-1
  • FNRB
  • ITGB1
  • MDF2
  • MSK12
view
P06756 Integrin alpha-V
  • ITGAV
  • MSK8
  • VNRA
  • VTNR
view
P07355 Annexin A2
  • ANX2
  • ANX2L4
  • ANXA2
  • CAL1H
  • LPC2D
view
P08648 Integrin alpha-5
  • FNRA
  • ITGA5
view
P18031 Tyrosine-protein phosphatase non-receptor type 1
  • PTP1B
  • PTPN1
view

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026