GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **351 - 375** of **499** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Aurora/IPL1-related protein kinase 2 Cullin-1 MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 RING-box protein 1 Skp1-related protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	G5ECU1 O01427 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P37165 P46502 P49632 P90868 P91477 Q04908 Q10920 Q17389 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q23457 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 air-2 cul-1 lin-19 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 skr-1 stu-7 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Adherens junctions interactions	Afadin Ig-like domain-containing protein	A7LPD6 Q86NJ4	afd-1 igcm-3	Caenorhabditis elegans
Phase 0 - rapid depolarisation	Guanylate kinase/L-type calcium channel beta subunit domain-containing protein SH3 domain-containing protein STarGazin (Mammalian calcium channel) homolog STarGazin (Mammalian calcium channel) homolog Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent calcium channel unc-36	A0A078BQJ0 G5EBI8 G5EDT2 O01661 P34374 Q8MQA1	STG-1 ccb-1 ccb-2 egl-19 stg-1 stg-2 unc-36 unc-72	Caenorhabditis elegans
A tetrasaccharide linker sequence is required for GAG synthesis	Beta-1,3-galactosyltransferase sqv-2 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase GlyPicaN Ig-like domain-containing protein InTestinal NeureXin-like LONg Laminin G domain-containing protein Probable syndecan Thioredoxin domain-containing protein Titin homolog Xylosylprotein 4-beta-galactosyltransferase Xylosyltransferase sqv-6	A0A0K3AUF6 C6KRM7 G4SLH0 G5ECV3 G5EGU4 O02304 O17708 O17751 O45000 O62113 P34548 P50605 Q09363 Q18530 Q22574 Q965Q8 Q9N491 Q9XU73	C03H12.1 CELE_T19D12.6 glct-1 glct-2 glct-3 glct-4 glct-5 glct-6 gpn-1 itx-1 lon-2 rig-5 sdn-1 sqv-2 sqv-3 sqv-6 sqv-8 ttn-1	Caenorhabditis elegans
Acyl chain remodelling of PC	C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Lipase_GDSL domain-containing protein Lysophospholipid acyltransferase 5 Lysophospholipid acyltransferase Membrane Bound O-Acyl transferase, MBOAT PNPLA domain-containing protein Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2 lysoplasmalogenase phospholipase A2	G4RY15 G5EC53 H9G2W5 O01925 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q18339 Q21552 Q22591 Q3V5J7 Q8MXR3 Q95YD2 Q9N2Z4 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 C45B2.6 CELE_M176.4 CELE_Y65B4BR.1 CELE_Y69A2AL.2 LPT-1 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 ipla-6 mboa-3 mboa-4 mboa-6	Caenorhabditis elegans
Degradation of DVL	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-3 DiSHevelled related DiSHevelled related E3 ubiquitin-protein ligase hecw-1 MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 RING-box protein 1 Segment polarity protein dishevelled homolog mig-5 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A0K3AUI8 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P37165 P46502 P49632 P90868 P91477 Q04908 Q09291 Q10920 Q17391 Q17971 Q18115 Q18239 Q18787 Q19324 Q20058 Q20585 Q20938 Q22227 Q22253 Q23237 Q23449 Q23457 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 cul-3 dsh-1 dsh-2 hecw-1 mig-5 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
MET receptor recycling	ADP-ribosylation factor 6 ADP-ribosylation factor-binding protein GGA1 Cell death abnormality protein 2 Kringle domain-containing protein Protein kinase domain-containing protein Sex muscle abnormal protein 5 Tyrosine-protein kinase receptor svh-2	H2KZU7 P29355 P91823 Q23165 Q9NHC3 Q9U2S4 Q9XVQ7	CELE_F11E6.8 CELE_T22A3.6 apt-9 arf-6 ced-2 sem-5 svh-2	Caenorhabditis elegans
O-glycosylation of TSR domain-containing proteins	A disintegrin and metalloproteinase with thrombospondin motifs gon-1 Apple domain-containing protein GDP-fucose protein O-fucosyltransferase 2 N-acetylgalactosaminide beta-1,3-galactosyltransferase SMB domain-containing protein ShKT domain-containing protein Spondin-1 Thrombospondin type-1 domain-containing protein 1	O01878 O18003 Q19284 Q19305 Q19349 Q19791 Q22631 Q8WR51	CELE_F09F9.4 CELE_F11C7.2 CELE_T21B6.3 CELE_ZC250.2 gon-1 pad-2 sbsp-1 spon-1	Caenorhabditis elegans
ABC-family proteins mediated transport	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ABC transmembrane type-1 domain-containing protein ABC transporter domain-containing protein ABC transporter domain-containing protein ABC-type antigen peptide transporter Derlin-1 Derlin-2 E3 ubiquitin ligase rnf-5 Endoplasmic reticulum lectin 1 Erlin Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 MPN domain-containing protein MRH domain-containing protein Multidrug resistance protein mrp-7 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 5 Multidrug resistance-associated protein lethal(2)03659 PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 S5 DRBM domain-containing protein Transitional endoplasmic reticulum ATPase homolog 2 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein protein-synthesizing GTPase	A3QMC6 G5EE72 G5EFG0 G5EFP3 O02086 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P37165 P46502 P49632 P54812 P90868 P91477 Q04908 Q09396 Q09463 Q10920 Q17971 Q18115 Q18787 Q19048 Q19324 Q19554 Q19625 Q20058 Q20585 Q20938 Q20943 Q21230 Q21997 Q22253 Q23237 Q23449 Q27488 Q3S1M2 Q93561 Q95005 Q95008 Q95PZ7 Q95XR0 Q966I8 Q9BKU3 Q9GZH5 Q9N599 Q9NF22 Q9U2G5 Q9XTT9 Q9XUV0 Q9XW61 S6EZS3	C14C10.5 CELE_F35G12.12 CELE_F48E8.4 CELE_Y105E8A.2 R151.6 abcf-1 abt-1 cdc-48.2 cup-2 der-1 eif-2alpha eif-2beta eif-2gamma erl-1 haf-2 iftb-1 mrp-1 mrp-2 mrp-3 mrp-4 mrp-5 mrp-6 mrp-7 mrp-8 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rnf-5 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 sel-1 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Interleukin-6 signaling	Fibronectin type-III domain-containing protein Protein kinase domain-containing protein Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b	D3YT30 Q20977 Q9NAD6 Q9UB28	CELE_T12G3.2 let-805 sta-1 sta-2 stat-b	Caenorhabditis elegans
HSF1-dependent transactivation	Calcium/calmodulin-dependent protein kinase type II DAF-15 DUF148 domain-containing protein Heat shock factor-binding protein 1 Heat shock protein 90 Heat shock protein Hsp-12.2 Heat shock protein hsp-1 Heat shock transcription factor hsf-1 Target of rapamycin complex subunit lst8 Target of rapamycin homolog	G5EC99 G5EFT5 O62305 P09446 P34328 P91040 Q18688 Q68TI8 Q95Q95 Q9U3B7	CELE_F11F1.1 CeTor daf-15 daf-21 hsb-1 hsf-1 hsp-1 hsp-12.2 hsp12-2 hsp70a let-363 mlst-8 unc-43	Caenorhabditis elegans
PKA-mediated phosphorylation of key metabolic factors	Protein WBSCR14 homolog	P41846	mio mml-1	Caenorhabditis elegans
RUNX3 regulates CDKN1A transcription	BMP-like protein unc-129 Dauer larva development regulatory growth factor daf-7 Dwarfin sma-4 Protein dbl-1 Runt-related transcription factor rnt-1 Smad protein daf-8 Zinc Finger and Homeobox	G5EBY8 G5EEL5 G5EFQ5 P45897 P92172 Q21733 V6CLN5	cem-3 cet-1 daf-7 daf-8 dbl-1 mab-2 rnt-1 run-1 sma-4 unc-129 zfh-2	Caenorhabditis elegans
Dual incision in TC-NER	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cullin-4 Cyclin-dependent kinase 7 DNA damage-binding protein 1 DNA polymerase delta catalytic subunit DNA polymerase delta subunit 3 DNA polymerase epsilon catalytic subunit DNA polymerase epsilon subunit 3 DNA polymerase kappa DNA repair and recombination protein RAD54-like DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 ERCC1-like central domain-containing protein ERCC4 domain-containing protein General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 Intron-binding protein aquarius Polyubiquitin-A Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor SYF1 Probable DNA polymerase delta small subunit Probable DNA polymerase epsilon subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable replication factor A 73 kDa subunit Probable replication factor C subunit 5 Proliferating cell nuclear antigen Protein isy-1 Putative transcription elongation factor S-II RING-box protein 1 RNA polymerase Rpb4/RPC9 core domain-containing protein RPA_C domain-containing protein Replication factor C subunit 1 Replication factor C subunit 2 Replication factor C subunit 3 Replication factor C subunit 4 UV-stimulated scaffold protein A homolog Ubiquitin carboxyl-terminal hydrolase 7 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein WD_REPEATS_REGION domain-containing protein XPA C-terminal domain-containing protein Zinc finger protein 830	G5EBZ1 G5EFV5 K8F7X5 O02092 O02115 O17245 O44175 O44499 O62218 P0CG71 P16356 P34409 P34429 P34567 P37165 P49632 P52652 P53016 P90829 P91175 P91356 Q09645 Q10051 Q10578 Q17392 Q17684 Q18547 Q18841 Q18963 Q19196 Q19366 Q19537 Q19826 Q20716 Q21302 Q21554 Q21730 Q22139 Q22798 Q23088 Q23457 Q7JKC3 Q86D18 Q93338 Q93456 Q95PZ4 Q965S0 Q9GR61 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9U1Q7 Q9U3I0 Q9XVH6	CELE_F53H4.6 CELE_R04F11.3 CELE_T26A5.8 F10C2.4 F12F6.7 F44B9.8 T24H10.1 ama-1 cdk-7 csa-1 cul-4 ddb-1 emb-4 ercc-1 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2h1 gtf-2h3 isy-1 math-33 mnat-1 pcn-1 pole-1 pole-2 polk-1 prp-19 rbx-1 rfc-1 rfc-2 rfc-3 rfc-4 rpa-1 rpa-4 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 sel-13 syf-1 ubia ubib ubl-1 ubq-1 ubq-2 usp-7 uvs-1 xpa-1 xpb-1 xpd-1 xpf-1	Caenorhabditis elegans
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Cathepsin L-like SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein	A9Z1L1 G5ECY2 G5EE40 G5EFH4 O17365 O45520 O45734 Q18287 Q19651 Q9XVQ1	C28G1.2 CELE_F15D3.4 CELE_F44G3.7 cpl-1 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8	Caenorhabditis elegans
ERK/MAPK targets	Mitogen-activated protein kinase mpk-1 Mitogen-activated protein kinase pmk-1 Mitogen-activated protein kinase pmk-2 Mitogen-activated protein kinase pmk-3 Mitogen-activated protein kinase Probable serine/threonine-protein phosphatase PP2A regulatory subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Putative ribosomal protein S6 kinase alpha-1 Putative ribosomal protein S6 kinase alpha-2 Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit	A9UJN4 G5EFV1 G5EGK8 H2KYF8 O44514 P39745 P91267 Q09543 Q17446 Q18846 Q21734 Q8MXI4 Q93344 Q9U3L3 Q9XX60 Q9XXC0	C49C3.10 CELE_F21F3.2 CELE_Y106G6D.4 CELE_Y106G6E.1 CELE_Y51B9A.9 gska-3 gskl-2 let-92 mpk-1 mpk-2 paa-1 pmk-1 pmk-2 pmk-3 pptr-2 rskn-1 rskn-2 sur-1	Caenorhabditis elegans
Antimicrobial peptides	BPI1 domain-containing protein C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Phospholipase A2 Phospholipase A2 Phospholipase A2	G4RY15 H9G2Z8 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q22591 Q3V5J7 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 CELE_F10D11.6 CELE_Y69A2AL.2 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89	Caenorhabditis elegans
PI-3K cascade:FGFR1	EGL-17 Glycoside hydrolase family 1 protein Glycoside hydrolase family 1 protein Myoblast growth factor receptor egl-15 Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Protein let-756 Sex muscle abnormal protein 5	G5EDP9 G5EEF1 P29355 Q10656 Q11184 Q18758 Q94125 Q9TZA0	aap-1 age-1 egl-15 egl-17 klo-1 klo-2 let-756 sem-5	Caenorhabditis elegans
Na+/Cl- dependent neurotransmitter transporters	Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Organic cation transporter 1 Putative transporter B0252.3 Putative transporter B0361.11 Sodium-dependent dopamine transporter Sodium-dependent nutrient amino acid transporter 1 Sodium-dependent transporter snf-5 Transporter Transporter Transporter Uncharacterized protein F23F12.3	A0A0K3AVV4 A0A0K3AWD3 A0A238UKL7 G5EBM5 G5EDA7 G5EE39 G5EEI9 G5EF43 G5EGL6 O18247 P46499 P90890 Q03614 Q09617 Q10917 Q18613 Q18655 Q18795 Q19442 Q22686 Q23501 Q4PIX1 Q7Z118 Q9BKR9 Q9GNP0 Q9U539 Q9UAW9 Q9XUG5	B0252.3 B0361.11 C06H5.6 C44C10.3 C46C2.2 CELE_F23F12.13 CELE_F45E10.2 CELE_K05F1.6 CELE_K09E9.1 CELE_K11D9.3 CELE_T08B1.1 CELE_T12B3.2 CELE_T22F7.1 CELE_Y57G11C.23 CELE_Y82E9BR.16 CELE_ZK892.3 F23F12.3/F23F12.1 cat-1 dat-1 oct-1 oct-2 pes-23 snf-11 snf-2 snf-5 snf-7 snf-9 suex-2	Caenorhabditis elegans
CREB phosphorylation	MAP kinase-activated protein kinase mak-1 MAP kinase-activated protein kinase mak-2 Putative ribosomal protein S6 kinase alpha-1 Putative ribosomal protein S6 kinase alpha-2	Q18846 Q21360 Q21734 Q965G5	mak-1 mak-2 rskn-1 rskn-2	Caenorhabditis elegans
Downregulation of TGF-beta receptor signaling	BMP-like protein unc-129 Cell surface receptor daf-1 Cell surface receptor daf-4 Dauer larva development regulatory growth factor daf-7 E3 ubiquitin-protein ligase CHIP Mothers against decapentaplegic homolog Polyubiquitin-A Protein dbl-1 Smad protein daf-8 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	G5EBY8 G5ECY6 G5EDS9 G5EEL5 P0CG71 P20792 P37165 P49632 P50488 P92172 Q21733	1G758 cet-1 chn-1 daf-1 daf-4 daf-7 daf-8 dbl-1 tag-68 ubia ubib ubl-1 ubq-1 ubq-2 unc-129	Caenorhabditis elegans
PAOs oxidise polyamines to amines	Amine oxidase domain-containing protein	O76383	hpo-15	Caenorhabditis elegans
Surfactant metabolism	ABC transporter domain-containing protein Aspartic protease 4 G-protein coupled receptors family 1 profile domain-containing protein GATA-type domain-containing protein GATA-type domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Saposin B-type domain-containing protein Saposin B-type domain-containing protein Sodium-dependent phosphate transport protein 2B TEStin (Human testis-derived transcript) homolog Transcription factor elt-1 Transcription factor elt-2 Transcription factor elt-6 Transcription factor elt-7	G5EF25 G5EF71 G5EGN3 O61924 P28515 Q10655 Q17525 Q18276 Q18279 Q19779 Q1ZXT2 Q20827 Q21966 Q23530 Q9TXV8	CELE_F55D10.4 CELE_ZK563.2 abt-4 ador-1 asp-4 elt-1 elt-2 elt-6 elt-7 gtr-1 med-1 med-2 spp-10 spp-8 tes-1	Caenorhabditis elegans
SHC1 events in EGFR signaling	EGF-like domain-containing protein EGF-like domain-containing protein Ras protein let-60 Receptor tyrosine-protein kinase let-23 Sex muscle abnormal protein 5 Son of sevenless homolog	G5EFK8 O44191 P22981 P24348 P29355 Q9N5D3	CELE_F14B4.1 kin-7 let-23 let-341 let-60 lin-34 rme-2 sem-5 sos-1	Caenorhabditis elegans
Neddylation	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein AO66 ankyrin Ankyrin repeat and KH domain-containing protein mask-1 B30.2/SPRY domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein BZIP domain-containing protein COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 5 COP9 signalosome complex subunit 6 Coiled-coil domain-containing protein 22 homolog Cullin-1 Cullin-2 Cullin-3 Cullin-4 Cullin-5 Cullin-associated NEDD8-dissociated protein 1 DDB1- and CUL4-associated factor 11 homolog DDB1- and CUL4-associated factor 13 DNA damage-binding protein 1 Death domain-containing protein Defective in cullin neddylation protein 1 Elongin-C F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box protein dre-1 F-box/LRR-repeat protein fbxl-1 F-box/WD repeat-containing protein mec-15 Hypoxia-inducible factor 1 Ion transport domain-containing protein MPN domain-containing protein NEDD8-activating enzyme E1 catalytic subunit NEDD8-activating enzyme E1 regulatory subunit NEDD8 Nuclear protein localization protein 4 homolog 2 PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Probable histone-binding protein lin-53 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein LAZ1 Protein skinhead-1 RING-box protein 1 RING-type domain-containing protein RING-type domain-containing protein RNA polymerase II transcription factor SIII p18 subunit Retinoblastoma-binding protein homolog 5 SH2 domain-containing protein SOCS box domain-containing protein SPRY domain-containing SOCS box protein 1 Sex-determining protein fem-1 Skp1-related protein Transcription factor che-1 Transitional endoplasmic reticulum ATPase homolog 2 Tubby C-terminal domain-containing protein Ubiquitin carboxyl-terminal hydrolase Ubiquitin fusion degradation protein 1 homolog Ubiquitin-conjugating enzyme E2 2 Ubiquitin-like protease family profile domain-containing protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized WD repeat-containing protein F47D12.9 Uncharacterized protein T23G5.3 WD and tetratricopeptide repeats protein 1 WD repeat-containing protein wdr-5.1 WD repeat-containing protein wdr-5.2 WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein Zeta_toxin domain-containing protein Zinc finger protein zfp-2 von Hippel-Lindau tumor suppressor homolog	A0A0K3AQR5 A0A0M7REQ4 A0PD34 G5ECR7 G5ECU1 G5ED41 G5EFS1 G5EGD2 G5EGS4 O01422 O16368 O17071 O17324 O17586 O18152 O44156 O45323 O45498 O61742 O61792 O61795 O62102 O62200 O76371 O76577 P0CG71 P17221 P34284 P34707 P35129 P37165 P46502 P49632 P54812 P90794 P90868 P90916 P91001 P91404 P91477 Q03607 Q04908 Q09309 Q09392 Q09397 Q10920 Q17389 Q17390 Q17391 Q17392 Q17490 Q17962 Q17963 Q17971 Q18115 Q18217 Q18587 Q18787 Q18963 Q19213 Q19324 Q19360 Q19584 Q20058 Q20082 Q20183 Q20585 Q20938 Q21554 Q21920 Q21934 Q22015 Q22059 Q22071 Q22253 Q23237 Q23449 Q23457 Q23494 Q23595 Q23639 Q27488 Q4W5Q8 Q7JP60 Q86FN3 Q93349 Q93725 Q93759 Q93847 Q94251 Q95005 Q95008 Q95PZ0 Q95PZ7 Q95QZ9 Q965F9 Q965N6 Q965N7 Q965V9 Q966I8 Q966L8 Q9BKS1 Q9BL53 Q9GRV5 Q9GS00 Q9GYM5 Q9GZH5 Q9N359 Q9N425 Q9N599 Q9U3C8 Q9XTT9 Q9XUV0	3L686 C10E2.2 C14B1.3 C14C10.5 CELE_F32B4.5 CELE_F35G12.12 CELE_F39B2.5 CELE_M60.7 CELE_R08E3.3 CELE_R11D1.1 CELE_R31.2 CELE_T28D6.4 CELE_T28F2.2 CELE_VM106R.1 CELE_ZK792.4 F47D12.9 T23G5.3 adpr-1 cand-1 ccd-3 cdc-48.2 cdt-2 cfl-1 che-1 csa-1 csn-1 csn-2 csn-3 csn-4 csn-5 csn-6 cul-1 cul-2 cul-3 cul-4 cul-5 dcaf-13 dcn-1 ddb-1 div-3 dre-1 elb-1 elc-1 fbxl-1 fem-1 hif-1 ikb-1 isx-1 kel-1 kel-20 let-70 lin-19 lin-53 lsy-15 mask-1 mec-15 mfb-1 mtpn-1 ned-8 npl-4.2 par-2 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rba-2 rbbp-5 rbx-1 rbx-2 rfl-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 skn-1 sknr-1 skpt-1 skr-1 spsb-1 spsb-2 swah-1 swan-2 swd-3.1 swd-3.2 tag-125 tag-30 trp-4 tub-2 uba-3 ubc-2 ubh-3 ubia ubib ubl-1 ubq-1 ubq-2 ufd-1 ula-1 ulp-3 unc-44 vhl-1 wdr-23 wdr-5.1 wdr-5.2 zfp-2	Caenorhabditis elegans

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