GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **401 - 425** of **499** in total

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Pathway Name	Protein Name ▼	UniProt ID	Gene Symbol	Organism
VLDLR internalisation and degradation	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain EGF-like domain-containing protein Probable clathrin heavy chain 1	P34574 P35603 P90961 Q19123 Q22601 Q7JP80 Q9N4F3	ap50 apa-2 apb-1 aps-2 chc-1 clic-1 dpy-23 gldi-2	Caenorhabditis elegans
Recycling pathway of L1	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain Dynamin Endophilin-A homolog Ig-like domain-containing protein Mitogen-activated protein kinase mpk-1 Moesin/ezrin/radixin homolog 1 Probable clathrin heavy chain 1 Tyrosine protein-kinase src-1	B1V8A0 G5EBK3 G5EE56 P34574 P35603 P39055 P39745 P90961 Q19123 Q22601 Q5WRR1 Q9N4F3	ap50 apa-2 apb-1 aps-2 chc-1 clic-1 dpy-23 dyn-1 erm-1 mpk-1 src-1 sur-1 unc-57 wrk-1	Caenorhabditis elegans
EPH-ephrin mediated repulsion of cells	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain DH domain-containing protein Dynamin Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin receptor 1 Ephrin-4 Gamma-secretase subunit aph-1 Gamma-secretase subunit pen-2 MMP-like protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Nicastrin Peptidase metallopeptidase domain-containing protein Presenilin sel-12 Probable clathrin heavy chain 1 Protein vav-1 Ras-related protein ced-10 Tyrosine protein-kinase src-1 Uncharacterized protein	G5EBU3 G5ECC4 G5EE56 G5EEE7 G5EGM1 O01847 O17913 O44516 O44836 O45876 O61460 P34574 P35603 P39055 P52166 P90961 Q03206 Q19123 Q19475 Q21182 Q22601 Q23316 Q45FX5 Q9N4F3 Q9U357 Q9U3M2	CELE_K03B8.6 ap50 apa-2 apb-1 aph-1 aph-2 aps-2 ced-10 chc-1 clic-1 dpy-23 dyn-1 efn-2 efn-3 efn-4 mab-26 pen-1 pen-2 rac-1 sel-12 src-1 tiam-1 vab-1 vab-2 vav-1 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
WNT5A-dependent internalization of FZD4	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Beta-arrestin arr-1 Clathrin light chain DiSHevelled related DiSHevelled related Frizzled-4 Probable clathrin heavy chain 1 Protein Wnt-2 Protein kinase C-like 2 Segment polarity protein dishevelled homolog mig-5	A0A0K3AUI8 G5EDV1 P34574 P34889 P35603 P51485 P90961 P90980 Q18239 Q19123 Q22227 Q22601 Q9N4F3	ap50 apa-2 apb-1 aps-2 arr-1 chc-1 clic-1 cwn-2 dpy-23 dsh-1 dsh-2 kin-11 lin-17 mig-5 pkc-2 wnt-2	Caenorhabditis elegans
Cargo recognition for clathrin-mediated endocytosis	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Beta-arrestin arr-1 C2 domain-containing protein C2 domain-containing protein C2 domain-containing protein C2 domain-containing protein COP9 signalosome complex subunit 1 COP9 signalosome complex subunit 2 COP9 signalosome complex subunit 3 COP9 signalosome complex subunit 4 COP9 signalosome complex subunit 5 COP9 signalosome complex subunit 6 Clathrin light chain DiSHevelled related DiSHevelled related E3 ubiquitin-protein ligase CBL EGF-like domain-containing protein EGF-like domain-containing protein EHS-1 ENTH domain-containing protein Endophilin-A homolog FCH domain only protein 2 Frizzled-4 G-protein coupled receptors family 1 profile domain-containing protein Hepatocyte growth factor-regulated tyrosine kinase substrate Intersectin-1 Multidrug resistance-associated protein lethal(2)03659 Muscarinic acetylcholine receptor gar-3 NECAP PHear domain-containing protein NEDD8 Phosphatidylinositol-binding clathrin assembly protein unc-11 Polyubiquitin-A Probable G-protein coupled receptor tkr-1 Probable clathrin heavy chain 1 Protein Wnt-2 Putative stoned B-like protein Receptor tyrosine-protein kinase let-23 SH3 domain-containing protein Segment polarity protein dishevelled homolog mig-5 Sensory neuron membrane protein 2 Sex muscle abnormal protein 5 Signal transducing adapter molecule 1 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptotagmin 2 Synaptotagmin-1 Torsin-like protein Torsin Torsin UBA domain-containing protein Ubiquilin Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Vesicular acetylcholine transporter unc-17	A0A0K3AS36 A0A0K3AUI8 B1V8A0 G5EBK2 G5EDV1 G5EFF7 G5EFK8 K8FE10 O01422 O01498 O02495 O16700 O18014 O44191 O45271 P0CG71 P24348 P29355 P34351 P34574 P34693 P34711 P34889 P35603 P37165 P49632 P51485 P90761 P90879 P90961 P91001 P91493 Q03566 Q17796 Q18239 Q19019 Q19123 Q19136 Q19625 Q19767 Q22227 Q22601 Q23056 Q6A573 Q93725 Q94057 Q95NU5 Q95PZ0 Q95XH1 Q9BI71 Q9BIF4 Q9GS00 Q9N359 Q9N425 Q9N489 Q9N4F3 Q9TXS0 Q9U7D5 Q9XTT3 Q9XXG5 Q9XZI6	CELE_F14B4.1 CELE_F49C12.9 CELE_T27E4.1 ap50 apa-2 apb-1 aps-2 apt-10 arr-1 cdap-2 chc-1 clic-1 csn-1 csn-2 csn-3 csn-4 csn-5 csn-6 cwn-2 dpy-23 dsh-1 dsh-2 ehs-1 epn-1 fcho-1 gar-3 hgrs-1 itsn-1 kin-7 let-23 lin-17 mig-5 mrp-6 ncap-1 ned-8 npr-25 ooc-5 pqn-19 rme-2 scav-3 sem-5 sli-1 snb-1 snb-2 snb-5 snb-6 snb-7 snt-1 snt-2 snt-4 snt-5 stam-1 sue-1 tkr-1 tor-1 tor-2 ubia ubib ubl-1 ubq-1 ubq-2 ubql-1 unc-11 unc-17 unc-41 unc-57 vamp-7 wnt-2	Caenorhabditis elegans
LDL clearance	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Alpha/beta hydrolase fold-3 domain-containing protein Alpha/beta hydrolase fold-3 domain-containing protein Alpha/beta hydrolase fold-3 domain-containing protein Alpha/beta hydrolase fold-3 domain-containing protein Carboxylic ester hydrolase Clathrin light chain EGF-like domain-containing protein NPC intracellular cholesterol transporter 1 homolog 2 O-acyltransferase Probable clathrin heavy chain 1 Putative protein heh-1	A0A1C3NSL8 O17271 P34389 P34574 P35603 P90961 Q17498 Q19123 Q19839 Q22601 Q7JMM5 Q7JP80 Q94187 Q9N4F3 Q9XWL5	CELE_F16F9.4 CELE_T09B9.1 ap50 apa-2 apb-1 aps-2 cest-26 chc-1 clic-1 dpy-23 gldi-2 heh-1 mboa-1 nceh-1 ncr-2 npc-2 trcs-1	Caenorhabditis elegans
Clathrin-mediated endocytosis	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Actin-related protein 2/3 complex subunit 5 Actin-related protein 2/3 complex subunit Actin-related protein 2 Actin-related protein 3 Amphiphysin Beta-arrestin arr-1 C2 domain-containing protein C2 domain-containing protein C2 domain-containing protein C2 domain-containing protein Clathrin light chain DiSHevelled related DiSHevelled related Dynamin E3 ubiquitin-protein ligase CBL EGF-like domain-containing protein EGF-like domain-containing protein EHS-1 ENTH domain-containing protein Endophilin-A homolog FCH domain only protein 2 Frizzled-4 G-protein coupled receptors family 1 profile domain-containing protein Heat shock protein hsp-1 Hepatocyte growth factor-regulated tyrosine kinase substrate Huntington interacting protein related 1 Intersectin-1 J domain-containing protein Multidrug resistance-associated protein lethal(2)03659 Muscarinic acetylcholine receptor gar-3 NECAP PHear domain-containing protein PIPK domain-containing protein Phosphatidylinositol-binding clathrin assembly protein unc-11 Polyubiquitin-A Probable G-protein coupled receptor tkr-1 Probable actin-related protein 2/3 complex subunit 2 Probable actin-related protein 2/3 complex subunit 3 Probable actin-related protein 2/3 complex subunit 4 Probable clathrin heavy chain 1 Protein Wnt-2 Putative stoned B-like protein Receptor tyrosine-protein kinase let-23 Receptor-mediated endocytosis protein 6 Rho-GAP domain-containing protein SH3 domain-containing protein SH3 domain-containing protein Segment polarity protein dishevelled homolog mig-5 Sensory neuron membrane protein 2 Sex muscle abnormal protein 5 Signal transducing adapter molecule 1 Sorting nexin lst-4 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptojanin Synaptotagmin 2 Synaptotagmin-1 Transducer of Cdc42-dependent actin assembly protein 1 homolog Transducer of Cdc42-dependent actin assembly protein 2 homolog Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Vesicular acetylcholine transporter unc-17 small monomeric GTPase	A0A0K3AS36 A0A0K3AUI8 A0A3P6PCS5 A0A486WXP9 B1V8A0 G5EBK2 G5ECL2 G5EDV1 G5EFK8 K8FE10 O01498 O01759 O02495 O16700 O17590 O18014 O44191 O61861 P09446 P0CG71 P24348 P29355 P34351 P34574 P34693 P34711 P34889 P35603 P37165 P39055 P49632 P51485 P53489 P58798 P90761 P90961 P91493 P91857 Q02328 Q03566 Q17796 Q18239 Q19019 Q19123 Q19136 Q19253 Q19625 Q19767 Q21004 Q22227 Q22601 Q23056 Q6A573 Q6AHQ8 Q8I4E2 Q8WTM6 Q94057 Q95XH1 Q9BI71 Q9BIF4 Q9GYH7 Q9N489 Q9N4F3 Q9N4I0 Q9TXS0 Q9U7D5 Q9XTT3 Q9XUS7 Q9XWV3 Q9XZI6	CELE_F14B4.1 CELE_T27E4.1 amph-1 ap50 apa-2 apb-1 aps-2 apt-10 arp-2 arr-1 arx-1 arx-2 arx-3 arx-4 arx-5 arx-6 arx-7 cdap-2 chc-1 clic-1 cwn-2 dnj-25 dpy-23 dsh-1 dsh-2 dyn-1 ehs-1 epn-1 fcho-1 gar-3 hgrs-1 hipr-1 hsp-1 hsp70a itsn-1 kin-7 let-23 lin-17 lst-4 mig-5 mrp-6 ncap-1 npr-25 ocrl-1 ppk-1 pqn-19 rab-5 rme-2 rme-6 scav-3 sdpn-1 sem-5 sli-1 snb-1 snb-2 snb-5 snb-6 snb-7 snt-1 snt-2 snt-4 snt-5 stam-1 sue-1 tkr-1 toca-1 toca-2 ubia ubib ubl-1 ubq-1 ubq-2 unc-11 unc-17 unc-26 unc-41 unc-57 vamp-7 wnt-2	Caenorhabditis elegans
RHOH GTPase cycle	ANK_REP_REGION domain-containing protein Amino acid transporter Amino acid transporter Anion exchange protein Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 Caveolin-1 Caveolin-2 Excitatory amino acid transporter Glutamate carboxypeptidase 2 homolog Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial N-acetylated-alpha-linked acidic dipeptidase 2 Probable methionine synthase Probable rho GDP-dissociation inhibitor Protein FAM91A1 Protein kinase domain-containing protein Putative NipSnap protein K02D10.1 Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 Rap-GAP domain-containing protein Ras-related protein Rab-18 Ras-related protein Rab-7a Ras-related protein ced-10 Ras-related protein rac-2 Rho-associated protein kinase let-502 Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Stomatin-2 Synaptobrevin-1 Transitional endoplasmic reticulum ATPase homolog 2 Tyrosine protein-kinase src-1 Tyrosine-protein kinase csk-1 Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein kinase UBX domain-containing protein 2 Vang-like protein WD_REPEATS_REGION domain-containing protein	A0A061ADQ6 A0A0K3ARA3 B3WFV9 G5EBM6 G5ECJ6 G5EE56 G5EFU0 G5EGQ3 H2KY90 H2KZ40 O02495 O18210 O44326 O62219 P34492 P54812 P91406 P92199 Q03206 Q09582 Q10901 Q10953 Q17850 Q18462 Q18825 Q18879 Q19958 Q20496 Q21353 Q21751 Q22682 Q23146 Q23571 Q23595 Q93332 Q94051 Q94124 Q9BL44 Q9N2W5 Q9N4S6 Q9U3B5 Q9UAY8 Q9XW34 V6CLC2	C34F11.5 CELE_F33H2.2 CELE_K09B11.5 CELE_R151.1 CELE_T25B9.5 CELE_Y110A7A.9 CELE_Y52D5A.2 CELE_Y69E1A.3 CELE_Y71H2AM.12 CELE_ZK792.4 K02D10.1 abts-1 bar-1 cav-1 cav-2 cdc-48.2 ced-10 csk-1 dbt-1 gcp-2.1 gcp-2.2 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7 hgap-1 hmp-2 kin-21 let-502 max-2 metr-1 pak-1 pak-2 pvl-1 rab-7 rac-1 rac-2 rhi-1 snb-1 spy-1 src-1 sto-2 ubxn-2 vang-1 wrm-1	Caenorhabditis elegans
BBSome-mediated cargo-targeting to cilium	ADP-ribosylation factor-like protein 6 Bardet-Biedl syndrome 1 protein homolog Bardet-Biedl syndrome 2 protein homolog Bardet-Biedl syndrome 4 protein homolog Bardet-Biedl syndrome 5 protein homolog Bardet-Biedl syndrome 7 protein homolog G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein GDP/GTP exchange factor Sec2 N-terminal domain-containing protein Neuropeptide receptor 18 Probable G-protein coupled receptor C06G4.5 Protein pthb1 homolog Tetratricopeptide repeat protein 8	A0A0K3AXD3 A0A3B1DQQ4 O01514 P34311 Q09502 Q18510 Q19640 Q20759 Q20841 Q21626 Q23033 Q23049 Q5CZ52 Q9N452 Q9NEZ7 Q9XW70	C06G4.5 CELE_F54C9.11 arl-6 bbs-1 bbs-2 bbs-4 bbs-5 bbs-7 bbs-8 bbs-9 npr-16 npr-18 npr-23 npr-24 npr-26 npr-28 osm-12	Caenorhabditis elegans
RHOQ GTPase cycle	ADP-ribosylation factor-like protein 13B Amino acid transporter Amino acid transporter Anion exchange protein Arf-GAP domain-containing protein Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 Calponin-homology (CH) domain-containing protein Caveolin-1 Caveolin-2 Cdc-42 Related Protein Cell division control protein 42 homolog E3 ubiquitin-protein ligase wwp-1 Excitatory amino acid transporter Glutamate carboxypeptidase 2 homolog Intersectin-1 MAGUK family Multidrug resistance-associated protein lethal(2)03659 N-acetylated-alpha-linked acidic dipeptidase 2 Nicotinic receptor-associated protein 1 PDZ domain-containing protein Protein lap1 Protein let-99 Protein vav Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 Ras-related protein Rab-7a Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho GTPase-activating protein syd-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein SH3 domain-containing protein START domain-containing protein Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase mrck-1 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Stomatin-2 Synaptobrevin-1 Synaptosomal-associated protein Target of ERK kinase mpk-1 Transducer of Cdc42-dependent actin assembly protein 1 homolog Transducer of Cdc42-dependent actin assembly protein 2 homolog Vang-like protein WAPL domain-containing protein non-specific serine/threonine protein kinase non-specific serine/threonine protein kinase t-SNARE protein aex-4	A0A0K3AS36 A0A2K5AU23 A5PEW5 B3WFV9 G5EEN8 G5EF62 G5EFU0 G5EGQ3 H2KY90 H2KZH5 H2KZV6 H2L0N8 O01583 O02495 O17772 O18210 O18302 O44326 O45611 O61967 O62422 P91406 Q05062 Q10901 Q10953 Q17850 Q18825 Q18879 Q19253 Q19370 Q19467 Q19625 Q19958 Q20440 Q21025 Q21341 Q21353 Q21430 Q21751 Q22682 Q23130 Q23146 Q7JP75 Q86NH1 Q93332 Q94051 Q95XW5 Q9N2Z7 Q9UAY8 Q9XUB9 Q9XUS7 Q9XVH4	CELE_T04C9.1 abts-1 aex-4 arl-13 bar-1 cav-1 cav-2 cdc-42 citk-1 citk-2 crp-1 cyk-1 gcp-2.1 gcp-2.2 gei-1 git-1 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7 gopc-1 hmp-2 itsn-1 let-413 let-99 magu-1 max-2 mrck-1 mrp-6 nra-1 pak-1 pak-2 pes-7 pix-1 pvl-1 rab-7 rga-1 rga-5 rga-8 ric-4 snb-1 spy-1 srgp-1 sto-2 syd-1 tag-81 toca-1 toca-2 toe-2 uig-1 vang-1 wrm-1 wwp-1	Caenorhabditis elegans
MET receptor recycling	ADP-ribosylation factor 6 ADP-ribosylation factor-binding protein GGA1 Cell death abnormality protein 2 Kringle domain-containing protein Protein kinase domain-containing protein Sex muscle abnormal protein 5 Tyrosine-protein kinase receptor svh-2	H2KZU7 P29355 P91823 Q23165 Q9NHC3 Q9U2S4 Q9XVQ7	CELE_F11E6.8 CELE_T22A3.6 apt-9 arf-6 ced-2 sem-5 svh-2	Caenorhabditis elegans
trans-Golgi Network Vesicle Budding	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 E3 ubiquitin-protein ligase arc-1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Putative syntaxin-2 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein t-SNARE protein aex-4	A5PEW5 G5EBK2 G5EEN8 G5EGS5 O02495 O16000 P34351 Q09654 Q10943 Q19767 Q20574 Q94057 Q94231 Q95XH1	aex-4 arc-1 arf-1 arf-1.1 arf-1.2 arl-4 arl-6 gbf-1 phi-34 ric-4 snb-1 snb-2 snb-5 snb-6 snb-7 syn-2 syx-2 tag-81 unc-64 vamp-7	Caenorhabditis elegans
Lysosome Vesicle Biogenesis	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 AP complex subunit beta AP complex subunit sigma AP-1 complex subunit gamma AP-1 complex subunit mu-1-I Beta-arrestin arr-1 Biogenesis of lysosome-related organelles complex 1 subunit 1 Cathepsin Z-1 Cell-death-related nuclease 7 Charged multivesicular body protein 2a Clathrin light chain Dynamin E3 ubiquitin-protein ligase arc-1 Endophilin-A homolog Hepatocyte growth factor-regulated tyrosine kinase substrate MHD domain-containing protein Probable clathrin heavy chain 1 Synaptobrevin-1 Synaptobrevin-like protein 5 V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein	B1V8A0 G5EBK2 G5EGP8 O01755 O02495 O16369 P34351 P34387 P34574 P35602 P39055 P51485 P90961 Q09654 Q10943 Q17796 Q19767 Q22616 Q8WQB3 Q94057 Q94231 Q95XH1 Q9N4F3 Q9U2F6	apb-1 apg-1 apm-1 aps-1 arc-1 arf-1 arf-1.1 arf-1.2 arl-4 arl-6 arr-1 blos-1 chc-1 clic-1 cpz-1 crn-7 dyn-1 hgrs-1 snb-1 snb-2 snb-5 snb-6 snb-7 tag-198 unc-101 unc-57 vamp-7 vps-2	Caenorhabditis elegans
Golgi Associated Vesicle Biogenesis	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 AP complex mu/sigma subunit domain-containing protein AP complex subunit beta AP complex subunit sigma AP-1 complex subunit gamma AP-1 complex subunit mu-1-I AP-3 complex subunit beta Beta-arrestin arr-1 Carboxypeptidase D Clathrin light chain Dynamin E3 ubiquitin-protein ligase arc-1 Endophilin-A homolog Glutamate carboxypeptidase 2 homolog Huntington interacting protein related 1 J domain-containing protein MHD domain-containing protein N-acetylated-alpha-linked acidic dipeptidase 2 NECAP PHear domain-containing protein PX domain-containing protein PX domain-containing protein Phosphatidylinositol-binding clathrin assembly protein unc-11 Probable clathrin heavy chain 1 Protein YIPF Rab-GAP TBC domain-containing protein Rho-GAP domain-containing protein SNAPIN protein homolog Sorting nexin lst-4 Synaptobrevin-1 Synaptobrevin-like protein 5 Uncharacterized protein F13E6.1 V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein small monomeric GTPase	A0A486WXP9 B1V8A0 C6KRN3 D9PTP5 G5EBE2 G5EBK2 O01755 O02495 O16369 O17590 O44445 O45718 P34351 P34574 P35602 P39055 P51485 P55326 P90961 P91359 P91406 P91857 Q02328 Q09654 Q10943 Q19767 Q8I4E2 Q8T874 Q8WQB3 Q93332 Q94057 Q94231 Q95XH1 Q9GYJ9 Q9N489 Q9N4F3 Q9XZI6	CELE_W02D9.2 F13E6.1 apb-1 apb-3 apg-1 apm-1 aps-1 aps-3 arc-1 arf-1 arf-1.1 arf-1.2 arl-4 arl-6 arr-1 chc-1 clic-1 cpd-1 dnj-25 dyn-1 gcp-2.1 gcp-2.2 hipr-1 lst-4 ncap-1 ocrl-1 rab-5 snb-1 snb-2 snb-5 snb-6 snb-7 snpn-1 snx-1 snx-6 tbc-9 unc-101 unc-11 unc-57 vamp-7	Caenorhabditis elegans
COPI-dependent Golgi-to-ER retrograde traffic	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 ADP-ribosylation factor Alpha-soluble NSF attachment protein Arf-GAP domain-containing protein Centromere/kinetochore protein zw10 homolog Coatomer subunit alpha Coatomer subunit beta Coatomer subunit epsilon DUF727 domain-containing protein E3 ubiquitin-protein ligase arc-1 ER lumen protein-retaining receptor erd-2.1 ER lumen protein-retaining receptor erd-2.2 GOLD domain-containing protein Gamma-soluble NSF attachment protein Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Kinesin heavy chain Kinesin light chain Kinesin light chain Kinesin motor domain-containing protein Kinesin motor domain-containing protein Kinesin-associated protein Kinesin-like protein klp-12 Kinesin-like protein klp-19 Kinesin-like protein klp-20 Kinesin-like protein unc-104 Kinesin-like protein unc-104 Kinesin-like protein vab-8 Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Neuroblastoma-amplified sequence Probable coatomer subunit beta' Probable coatomer subunit delta Probable coatomer subunit gamma Probable coatomer subunit zeta RAB family Rac GTPase-activating protein 1 Suppressor/enhancer of lin-12 protein 9 Surfeit locus protein 4 homolog Transmembrane emp24 domain-containing protein bai Uncharacterized protein F07F6.4 Vesicle transport protein SEC20 Vesicle transport protein USE1 Vesicle-fusing ATPase Vesicle-trafficking protein SEC22b t-SNARE coiled-coil homology domain-containing protein	A0A4V0IKG7 C0Z1Y7 G5EBX0 G5ECF4 G5EEE6 G5EFK4 G5EFQ4 G5EGS3 G5EGS5 H9G2T2 O17528 O17901 O44738 O45935 O62246 O76413 P23678 P34540 P46822 P48583 P90841 P90904 P91400 Q09236 Q09473 Q09531 Q09654 Q10943 Q18864 Q18921 Q19633 Q19642 Q1RPT8 Q20168 Q20546 Q21441 Q22498 Q8MQ03 Q8MQ20 Q94231 Q94241 Q94392 Q965T6 Q9N4H7 Q9N598 Q9NEQ8 Q9TYL9 Q9UAQ6 Q9XU12 Q9XUS9	CELE_K02B12.7 CELE_Y59A8B.25 CELE_Y59A8B.8 F07F6.4 Y110A7A.11 arc-1 arf-1 arf-1.1 arf-1.2 arf-3 arf-5 arl-4 arl-6 bmk-1 copa-1 copb-1 copb-2 copd-1 cope-1 copg-1 copz-1 cyk-4 czw-1 erd-2 erd-2.1 erd-2.2 gbf-1 kap-1 khc-1 klc-1 klc-2 klp-11 klp-12 klp-13 klp-15 klp-18 klp-19 klp-20 klp-4 klp-6 klp-7 nsf-1 phi-34 rab-1 sec-20 sec-22 sel-9 sft-4 smgl-1 snap-1 surf-4 syx-18 tmed-10 tmed-3 unc-104 unc-116 vab-8 zen-4	Caenorhabditis elegans
COPI-mediated anterograde transport	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 ADP-ribosylation factor Actin-related protein 10 Actin Alpha-soluble NSF attachment protein BET1 Coatomer subunit alpha Coatomer subunit beta Coatomer subunit epsilon Conserved oligomeric Golgi complex subunit 1 Conserved oligomeric Golgi complex subunit 2 Conserved oligomeric Golgi complex subunit 3 Conserved oligomeric Golgi complex subunit 4 Conserved oligomeric Golgi complex subunit 5 Conserved oligomeric Golgi complex subunit 6 Conserved oligomeric Golgi complex subunit 8 DUF727 domain-containing protein Dynactin subunit 1 Dynactin subunit 4 Dynactin subunit 5 Dynactin subunit 6 Dynein heavy chain, cytoplasmic Dynein light chain 1, cytoplasmic Dynein light chain Dynein light chain Dynein light chain Dynein light chain Dynein light intermediate chain E3 ubiquitin-protein ligase arc-1 ER lumen protein-retaining receptor erd-2.1 ER lumen protein-retaining receptor erd-2.2 F-actin-capping protein subunit alpha F-actin-capping protein subunit beta GOLD domain-containing protein Gamma-soluble NSF attachment protein Golgi SNAP receptor complex member 1 Golgi SNAP receptor complex member 2 homolog memb-1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Golgin subfamily A conserved domain-containing protein PDZ GRASP-type domain-containing protein Probable coatomer subunit beta' Probable coatomer subunit delta Probable coatomer subunit gamma Probable coatomer subunit zeta Probable dynactin subunit 2 Probable dynein light chain 2, cytoplasmic Putative syntaxin-5 RAB family Spectrin alpha chain Spectrin beta chain Spectrin beta chain Suppressor/enhancer of lin-12 protein 9 Sushi domain-containing protein Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 Transmembrane emp24 domain-containing protein bai Transmembrane protein 115 Uncharacterized protein C50C3.2 Uso1_p115_head domain-containing protein Vesicle-fusing ATPase WD_REPEATS_REGION domain-containing protein YKT6 (Yeast v-SNARE) homolog	A0A1N7SYP5 A0AAC1 E0AHA7 E2JKZ0 G5ED34 G5EE66 G5EEU1 G5EFK4 G5EFW3 G5EGG0 G5EGS5 O17528 O17901 O44502 O44738 O45087 O62246 P34367 P34685 P34686 P41941 P48583 P91151 Q09236 Q09248 Q09473 Q09654 Q10943 Q18194 Q18849 Q18921 Q19020 Q19989 Q1RPT8 Q20168 Q20546 Q20797 Q21270 Q21408 Q21444 Q21557 Q22498 Q22799 Q65XS9 Q6AW08 Q7YTJ8 Q94231 Q94392 Q95XZ0 Q95ZW1 Q9GYR2 Q9N3F1 Q9N3Y1 Q9N4H7 Q9N4I1 Q9NA98 Q9NEQ8 Q9TXZ9 Q9TYL9 Q9U3K1 Q9UAQ6 Q9XWA8	C50C3.2/C50C3.3 C54G4.4 CELE_F11A10.6 CELE_Y42H9AR.1 CELE_Y59A8B.25 CELE_Y59A8B.8 arc-1 arf-1 arf-1.1 arf-1.2 arf-3 arf-5 arl-4 arl-6 arp-1 arp-11 cap-1 cap-2 cfh-1 cgo-2 cog-2 cogc-1 cogc-2 cogc-3 cogc-4 cogc-5 cogc-6 cogc-8 copa-1 copb-1 copb-2 copd-1 cope-1 copg-1 copz-1 dhc-1 dlc-1 dlc-2 dlc-3 dlc-4 dlc-5 dlc-6 dli-1 dnc-1 dnc-2 dnc-4 dnc-5 dnc-6 dyci-1 erd-2 erd-2.1 erd-2.2 gbf-1 golg-2 gos-28 gosr-1 gosr-2.1 gs28 ldlc memb-1 nbet-1 nsf-1 phi-34 rab-1 sel-9 sma-1 snap-1 spc-1 syn-3 syx-5 tmed-10 tmed-3 unc-70 uso-1 ykt-6	Caenorhabditis elegans
Synthesis of PA	ACid Phosphatase family C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Dihydroxyacetone phosphate acyltransferase Glycerol-3-phosphate dehydrogenase [NAD(+)] Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase Phospholipid/glycerol acyltransferase domain-containing protein Phospholipid/glycerol acyltransferase domain-containing protein Phospholipid/glycerol acyltransferase domain-containing protein Phospholipid/glycerol acyltransferase domain-containing protein Phospholipid/glycerol acyltransferase domain-containing protein Probable glycerol-3-phosphate acyltransferase, mitochondrial Probable glycerol-3-phosphate dehydrogenase 2 Probable glycerol-3-phosphate dehydrogenase, mitochondrial Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1 Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2	G4RY15 G5EDU3 G5EE59 G5EFP8 O16526 O16654 P34472 P34517 P90795 P91429 Q17450 Q17452 Q17790 Q18339 Q19460 Q21812 Q22267 Q22591 Q22949 Q3V5J7 Q93841 Q95R12 Q9N5S8 Q9TZ75 Q9XTS4 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 CELE_M79.2 CELE_Y69A2AL.2 PLD acl-1 acl-11 acl-2 acl-4 acl-5 acl-6 acl-7 acl-8 acp-3 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 dapat gpdh-1 gpdh-2 gpdh-3 pld-1	Caenorhabditis elegans
RHOA GTPase cycle	ACB domain-containing protein Anillin-like protein 2 Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 CED-5 CRAL-TRIO domain-containing protein Cadherin domain-containing protein Calponin-homology (CH) domain-containing protein Caveolin-1 Caveolin-2 Conserved regulator of innate immunity protein 3 DH domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein F-BAR domain-containing protein FH2 domain-containing protein FH2 domain-containing protein Formin-homology and zinc finger domains protein 1 Glutamate carboxypeptidase 2 homolog Guanine nucleotide exchange factor Moesin/ezrin/radixin homolog 1 N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Peroxisomal Membrane Protein related Phosphoinositide 3-kinase adapter subunit Phospholipase Probable rho GDP-dissociation inhibitor Protein ECT2 Protein kinase domain-containing protein Protein let-99 Protein vav-1 Protein vav Rac GTPase-activating protein 1 Ras-like GTP-binding protein rhoA Rho GTPase-activating protein 20 Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho guanine nucleotide exchange factor osg-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-associated protein kinase let-502 SH2 domain-containing protein SH3 domain-containing protein START domain-containing protein Sec1 family domain-containing protein 1 Stomatin-2 Synaptobrevin-1 Synaptosomal-associated protein Target of ERK kinase mpk-1 Tight junction protein ZO-1 UBX domain-containing protein Unconventional myosin-IXa-like Vang-like protein WAPL domain-containing protein WW domain-containing protein tag-325 protein kinase C t-SNARE protein aex-4	A0A0K3AQN0 A0A0K3AW57 A0A2K5AU23 A0A4V0IKG6 A0A4V0ILM7 A5PEW5 D6VPA1 F0IWT2 G5EDP9 G5EDU3 G5EEN3 G5EEN8 G5EF62 G5EF80 G5EFE1 H2KY90 H2KYI7 H2KZH5 H2KZV4 H2KZV6 O01443 O01847 O02495 O17772 O17905 O44326 O45611 O45628 O61528 P34489 P46941 P91406 P92199 Q09994 Q10953 Q17777 Q18598 Q18825 Q18879 Q19370 Q19479 Q19958 Q20364 Q20440 Q20496 Q21018 Q21341 Q21430 Q21653 Q22038 Q23130 Q45FX5 Q5F4U0 Q7JP75 Q8I103 Q93332 Q94051 Q965J0 Q9U364 Q9XTZ5 Q9XUS9 Q9XW53 S6EZU2 U4PAK0	C07B5.4 CELE_F23H11.4 CELE_H40L08.1 CELE_T04C9.1 CELE_Y105E8A.25 PLD aap-1 aex-4 ani-2 bar-1 cav-1 cav-2 cdh-10 ced-5 cgef-1 cri-3 cyk-1 cyk-4 daam-1 ect-2 ephx-1 fozi-1 frm-3 gck-4 gcp-2.1 gcp-2.2 gei-1 hmp-2 hum-7 inft-2 let-502 let-99 maa-1 osg-1 pes-7 pix-1 pkn-1 pld-1 pmp-2 pvl-1 rga-1 rga-2 rga-4 rga-5 rga-6 rga-8 rga-9 rhgf-1 rhgf-2 rhi-1 rho-1 rhoa ric-4 sly-1 snb-1 spv-1 spy-1 srgp-1 sto-2 tag-325 tag-81 tiam-1 toe-2 uig-1 unc-73 vang-1 vav-1 wrm-1 zoo-1	Caenorhabditis elegans
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ABC-type antigen peptide transporter ABC-type antigen peptide transporter ABC-type antigen peptide transporter Aminopeptidase-like protein AC3.5 Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase HAlF transporter (PGP related) HAlF transporter (PGP related) Peptidase_M1 domain-containing protein Protein transport protein SEC23 Protein transport protein Sec24C Puromycin-sensitive aminopeptidase Putative aminopeptidase-2 Small COPII coat GTPase SAR1 Yeast SEC homolog	A5A631 G5EGH4 H2L0M5 O02086 O18227 O44897 Q17405 Q19371 Q22317 Q22531 Q23368 Q23445 Q4TT88 Q9NAA0 Q9TZD9 Q9U275 Q9U2H2 Q9U2Z1 Q9XVV9	AC3.5 CELE_F49B2.6 CELE_R03G8.6 CELE_T12E12.6 CELE_Y42A5A.1 CELE_Y53F4B.20 CELE_Y67D8C.9 T16G12.1 anp-1 haf-2 haf-4 haf-7 haf-8 haf-9 pam-1 sar-1 sec-23 sec-24.1 sec-24.2	Caenorhabditis elegans
Surfactant metabolism	ABC transporter domain-containing protein Aspartic protease 4 G-protein coupled receptors family 1 profile domain-containing protein GATA-type domain-containing protein GATA-type domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Saposin B-type domain-containing protein Saposin B-type domain-containing protein Sodium-dependent phosphate transport protein 2B TEStin (Human testis-derived transcript) homolog Transcription factor elt-1 Transcription factor elt-2 Transcription factor elt-6 Transcription factor elt-7	G5EF25 G5EF71 G5EGN3 O61924 P28515 Q10655 Q17525 Q18276 Q18279 Q19779 Q1ZXT2 Q20827 Q21966 Q23530 Q9TXV8	CELE_F55D10.4 CELE_ZK563.2 abt-4 ador-1 asp-4 elt-1 elt-2 elt-6 elt-7 gtr-1 med-1 med-2 spp-10 spp-8 tes-1	Caenorhabditis elegans
Ciprofloxacin ADME	ABC transporter domain-containing protein ABC transporter family G domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Organic cation transporter 1 Putative transporter B0252.3 Putative transporter B0361.11 Solute carrier organic anion transporter family member Uncharacterized protein F23F12.3	A0A0K3AVV4 A0A0K3AWD3 A0A238UKL7 D7SFK1 G5EDA7 G5EEI9 G5EGL6 O18247 P46499 Q09617 Q10917 Q18613 Q18655 Q18795 Q19442 Q19585 Q22686 Q23501 Q4PIX1 Q7Z118 Q93550 Q9BKR9 Q9U539 Q9UAW9	B0252.3 B0361.11 C06H5.6 C44C10.3 C46C2.2 CELE_F21G4.1 CELE_F23F12.13 CELE_F45E10.2 CELE_K05F1.6 CELE_K09E9.1 CELE_K11D9.3 CELE_T08B1.1 CELE_T12B3.2 CELE_T22F7.1 CELE_Y57G11C.23 CELE_Y82E9BR.16 CELE_ZK892.3 F23F12.3/F23F12.1 abcx-1 oct-1 oct-2 pes-23 suex-2 wht-5	Caenorhabditis elegans
Iron uptake and transport	ABC transporter domain-containing protein ABC transporter family G domain-containing protein Cullin-1 Cullin-associated NEDD8-dissociated protein 1 Cytochrome b561 domain-containing protein Cytochrome b561 domain-containing protein Cytoplasmic aconitate hydratase Ferritin Ferritin NEDD8 NRAMP-like transporter smf-1 Polyubiquitin-A Proton-coupled folate transporter Putative transmembrane ascorbate-dependent reductase CYB561 homolog Skp1-related protein SoLute Carrier family Related SoLute Carrier family Related Solute carrier family 46 member 3 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized MFS-type transporter C09D4.1	D7SFK1 G5ECU1 G5ED41 H2KZC0 O01735 O16271 O16272 O16453 P0CG71 P34465 P37165 P49632 Q17389 Q19585 Q20236 Q21434 Q23500 Q93725 Q9TYS3 Q9UAZ6 Q9XWL3	C09D4.1 CELE_F39G3.4 CELE_F39G3.5 F55H2.5 abcx-1 aco-1 cand-1 cul-1 ftn-1 ftn-2 gei-22 lin-19 ned-8 skr-1 slc-46A slc-46a slcr-46.1 slcr-46.2 slcr-46.3 smf-1 ubia ubib ubl-1 ubq-1 ubq-2 wht-5	Caenorhabditis elegans
Linoleic acid (LA) metabolism	ABC transporter domain-containing protein Delta(5) fatty acid desaturase fat-4 Delta(6)-fatty-acid desaturase fat-3 Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Long chain fatty acid elongase 1 Long chain fatty acid elongase 2 Long chain fatty acid elongase 5 Long chain fatty acid elongase 6 Putative fatty acid elongase 3 Putative fatty acid elongase 4	F3Y5R4 G5EEE5 G5EG11 O45730 P49191 Q03574 Q20300 Q20303 Q20904 Q23221 Q9NAC6 Q9XVQ9	des-5 elo-1 elo-2 elo-3 elo-4 elo-5 elo-6 elo-7 elo-8 elo-9 fat-3 fat-4 pmp-4	Caenorhabditis elegans
alpha-linolenic acid (ALA) metabolism	ABC transporter domain-containing protein Acyl-coenzyme A oxidase acox-1.3 Delta(5) fatty acid desaturase fat-4 Delta(6)-fatty-acid desaturase fat-3 Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Long chain fatty acid elongase 1 Long chain fatty acid elongase 2 Long chain fatty acid elongase 5 Long chain fatty acid elongase 6 MaoC-like domain-containing protein Putative fatty acid elongase 3 Putative fatty acid elongase 4 palmitoyl-CoA hydrolase	F3Y5R4 G5EEE5 G5EG11 O45730 O62138 P49191 Q03574 Q19058 Q20300 Q20303 Q20904 Q23221 Q9BIA9 Q9NAC6 Q9XVQ9	C17C3.1 acox-1.3 acox-3 des-5 elo-1 elo-2 elo-3 elo-4 elo-5 elo-6 elo-7 elo-8 elo-9 fat-3 fat-4 maoc-1 pmp-4	Caenorhabditis elegans
Atorvastatin ADME	ABC transmembrane type-1 domain-containing protein Arylesterase Arylesterase Mechanosensory abnormality protein 6 Multidrug resistance protein mrp-7 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 PON (Paraoxonase) and MEC-6 Like SMP-30/Gluconolactonase/LRE-like region domain-containing protein Solute carrier organic anion transporter family member	B1V898 G5EFP3 O01811 Q19048 Q20943 Q21427 Q2V071 Q3S1M2 Q93550 Q966L1 Q9U2G5 Q9XW61	CELE_F21G4.1 mec-6 mrp-1 mrp-2 mrp-3 mrp-4 mrp-7 mrp-8 poml-1 poml-2 poml-3 poml-4	Caenorhabditis elegans

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