GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **26 - 50** of **499** in total

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Pathway Name ▲	Protein Name	UniProt ID	Gene Symbol	Organism
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Inositol 1,4,5-trisphosphate receptor itr-1 Stromal interaction molecule 1 Transient receptor ion channel domain-containing protein	G5EF60 Q8I6Y9 Q9Y0A1	dec-4 itr-1 lfe-1 stim-1 trp-2	Caenorhabditis elegans
Antigen processing: Ubiquitination & Proteasome degradation	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein ANK_REP_REGION domain-containing protein AO66 ankyrin Abnormal embryogenesis protein 30 Aminopeptidase-like protein AC3.5 Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Anaphase-promoting complex subunit 10 Anaphase-promoting complex subunit 11 Anaphase-promoting complex subunit 1 Anaphase-promoting complex subunit 2 Ankyrin repeat and KH domain-containing protein mask-1 B30.2/SPRY domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein BTB domain-containing protein C3H1-type domain-containing protein Cell division cycle protein 16 homolog Cell division cycle protein 23 homolog Cell division cycle protein 27 homolog Cullin-1 Cullin-2 Cullin-3 Cullin-5 DDB1- and CUL4-associated factor homolog 1 Death domain-containing protein E1 ubiquitin-activating enzyme E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E2 ubiquitin-conjugating enzyme E3 UFM1-protein ligase 1 homolog E3 ubiquitin-protein ligase CBL E3 ubiquitin-protein ligase CHIP E3 ubiquitin-protein ligase E3D E3 ubiquitin-protein ligase RBBP6 E3 ubiquitin-protein ligase TRIM9 E3 ubiquitin-protein ligase etc-1 E3 ubiquitin-protein ligase hecd-1 E3 ubiquitin-protein ligase hecw-1 E3 ubiquitin-protein ligase listerin E3 ubiquitin-protein ligase makorin E3 ubiquitin-protein ligase siah-1 E3 ubiquitin-protein ligase trul-1 E3 ubiquitin-protein ligase ubr-1 E3 ubiquitin-protein ligase wwp-1 E3 ubiquitin-protein ligase Elongin-C F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box domain-containing protein F-box protein dre-1 F-box/LRR-repeat protein fbxl-1 F-box/WD repeat-containing protein mec-15 F-box/WD repeat-containing protein sel-10 FERM domain (Protein4.1-ezrin-radixin-moesin) family HECT domain-containing protein HECT-type E3 ubiquitin transferase HECT-type E3 ubiquitin transferase Ion transport domain-containing protein K Homology domain-containing protein MPN domain-containing protein NEDD8-activating enzyme E1 catalytic subunit PCI domain-containing protein PDZ domain-containing protein PDZ domain-containing protein Peptidase_M1 domain-containing protein Polyubiquitin-A Potential E3 ubiquitin-protein ligase ariadne-2 Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Probable ubiquitin-conjugating enzyme E2 7 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein gfi-3 Protein kinase domain-containing protein Puromycin-sensitive aminopeptidase Putative aminopeptidase-2 RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RBR-type E3 ubiquitin transferase RING-box protein 1 RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RING-type E3 ubiquitin transferase RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RING-type domain-containing protein RNA polymerase II transcription factor SIII p18 subunit SPRY domain-containing SOCS box protein 1 Skp1-related protein Transcription factor che-1 Tripeptidyl-peptidase 2 UBC core domain-containing protein UBC core domain-containing protein UBR-type domain-containing protein Ubiquitin-conjugating enzyme E2 13 Ubiquitin-conjugating enzyme E2 1 Ubiquitin-conjugating enzyme E2 25 Ubiquitin-conjugating enzyme E2 2 Ubiquitin-conjugating enzyme E2 S Ubiquitin-conjugating enzyme E2 W Ubiquitin-conjugating enzyme E2 ubc-18 Ubiquitin-conjugating enzyme E2 variant 1 Ubiquitin-like modifier-activating enzyme 5 Ubiquitin-like modifier-activating enzyme ATG7 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein Uncharacterized protein T23G5.3 WD repeat-containing protein fzy-1 WD repeat-containing protein wdr-5.2 X-linked retinitis pigmentosa GTPase regulator homolog Zeta_toxin domain-containing protein Zinc finger protein zfp-2 von Hippel-Lindau tumor suppressor homolog	A0A061ACQ8 A0A0S4XR36 A0A2K5ATR7 A0A4V0IJV5 A0PD34 A5A631 A8DJA6 B1Q249 G5EBK4 G5ECR7 G5ECU1 G5ECY6 G5ECZ8 G5EFS1 G5EG38 G5EGH4 G5EGS4 H2L067 H2L0M5 H8W3Y2 L8E6Y3 O16368 O17071 O17324 O17586 O17736 O18152 O18191 O44156 O45323 O45495 O61742 O61792 O61795 O62102 O62200 O62235 O76371 O76577 O76671 P0CG71 P34284 P34441 P34477 P34514 P35129 P37165 P46502 P49632 P52478 P90868 P90990 P91133 P91404 P91430 P91477 Q03607 Q04908 Q09291 Q09373 Q09397 Q09541 Q10920 Q17389 Q17390 Q17391 Q17405 Q17490 Q17750 Q17911 Q17962 Q17971 Q18115 Q18587 Q18787 Q18931 Q19019 Q19213 Q19294 Q19324 Q19360 Q20052 Q20058 Q20082 Q20183 Q20585 Q20617 Q20874 Q20938 Q21106 Q21633 Q21920 Q22015 Q22071 Q22253 Q22317 Q22431 Q22531 Q22559 Q23237 Q23449 Q23457 Q23595 Q23639 Q27481 Q27488 Q2AAC0 Q2WF61 Q4TT88 Q5DX34 Q65XX2 Q93349 Q93571 Q93794 Q93847 Q93903 Q94251 Q95005 Q95008 Q95PZ7 Q95XN7 Q95XX0 Q965N6 Q965N7 Q965X6 Q966I8 Q966L8 Q9BKS1 Q9BL11 Q9GRV5 Q9GZH5 Q9N2W9 Q9N2Z7 Q9N373 Q9N3D1 Q9N3F9 Q9N3T6 Q9N4I6 Q9N593 Q9N599 Q9NA71 Q9NAA0 Q9TZ69 Q9U1Q1 Q9U2C5 Q9U2H2 Q9UAQ3 Q9XTT9 Q9XUV0 Q9XVV9 Q9XWF6 Q9XXE6 U4PBY0 V6CLA2	1G758 3L686 AC3.5 C10E2.2 C14B1.3 C14C10.5 C17H11.6 CELE_F32B4.5 CELE_F35G12.12 CELE_F49B2.6 CELE_F56D2.2 CELE_H10E21.5 CELE_R03G8.6 CELE_R31.2 CELE_T12E12.6 CELE_T19B10.5 CELE_T28D6.4 CELE_VM106R.1 CELE_Y42A5A.1 CELE_Y47G6A.14 CELE_Y48G1C.12 CELE_Y49F6B.9 CELE_Y53F4B.20 CELE_Y53G8AR.5 CELE_Y57A10A.31 CELE_Y67D8C.9 CELE_Y71F9AL.10 CELE_Y71H2AM.3 CELE_Y92H12A.2 CELE_ZK792.4 T16G12.1 T23G5.3 Y54E10A.11 anp-1 apc-1 apc-11 apc-2 apc-3 apc-6 apc-8 ari-2 atg-7 ccd-3 cdc-23 cdc-27 cfl-1 che-1 chn-1 cul-1 cul-2 cul-3 cul-5 dcaf-1 div-3 dre-1 eel-1 egl-41 elb-1 elc-1 emb-27 emb-30 etc-1 evl-22 fbxl-1 frm-5.1 frm-5.2 fzy-1 gfi-3 glo-4 hecd-1 hecw-1 herc-1 ikb-1 kel-1 kel-20 lep-2 let-70 lin-19 madd-2 mask-1 mat-1 mat-2 mat-3 mec-15 mex-3 mfb-1 mgrn-1 mib-1 mpz-1 mtpn-1 oxi-1 pam-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 pod-3 pod-4 pod-5 pod-6 psmd-9 psme-3 rbpl-1 rbx-1 rbx-2 rfl-1 rnf-126 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 sel-10 siah-1 skpt-1 skr-1 sli-1 spsb-1 spsb-2 swah-1 swd-3.2 tag-30 tpp-2 trim-9 trp-4 trul-1 uba-1 uba-3 uba-5 ubc-1 ubc-13 ubc-14 ubc-16 ubc-18 ubc-2 ubc-20 ubc-24 ubc-25 ubc-26 ubc-3 ubc-6 ubc-7 ubc-8 ubia ubib ubl-1 ubq-1 ubq-2 ubr-1 ubr-4 uev-1 ufl-1 unc-44 unk-1 vex-2 vhl-1 wdr-5.2 wwp-1 zfp-2	Caenorhabditis elegans
Antimicrobial peptides	BPI1 domain-containing protein C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Phospholipase A2 Phospholipase A2 Phospholipase A2	G4RY15 H9G2Z8 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q22591 Q3V5J7 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 CELE_F10D11.6 CELE_Y69A2AL.2 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89	Caenorhabditis elegans
Apoptotic cleavage of cell adhesion proteins	Beta-catenin-like protein hmp-2 Cadherin-4 Cell death protein 3 Juxtamembrane domain-associated catenin OCEL domain-containing protein Tight junction protein ZO-1	O44326 P42573 Q19319 Q8I103 Q9N554 Q9U308	cdh-4 ced-3 ell-1 hmp-2 jac-1 zoo-1	Caenorhabditis elegans
Apoptotic cleavage of cellular proteins	Adenomatous polyposis coli protein-related protein 1 Cell death protein 3 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Protein kinase C-like 1 Rho-associated protein kinase let-502 SAP domain-containing protein	O44501 P34722 P42573 P91156 P92199 Q21227	acin-1 apr-1 ced-3 fnta-1 let-502 tpa-1	Caenorhabditis elegans
Apoptotic execution phase	Dynamin-1-like protein drp-1 Endoplasmic reticulum transmembrane protein	G5EBI0 Q8WQC9	4D656 drp-1	Caenorhabditis elegans
Arachidonic acid metabolism	Acyltransferase Acyltransferase Acyltransferase Acyltransferase Amidase domain-containing protein Amidase domain-containing protein Amidase domain-containing protein Amidase domain-containing protein Amidase domain-containing protein Fatty acid amide hydrolase 1 Monoglyceride lipase faah-4	O01881 O45089 Q17447 Q17449 Q23067 Q9N4S3 Q9NAB7 Q9U217 Q9U243 Q9U2I8 Q9XUW0	CELE_K07B1.4 CELE_Y53F4B.18 CELE_Y53G8B.2 dgat-2 dgtr-1 faah-1 faah-2 faah-3 faah-4 faah-5 faah-6	Caenorhabditis elegans
Aryl hydrocarbon receptor signalling	Co-chaperone protein daf-41 Heat shock protein 90 TPR_REGION domain-containing protein	Q18688 Q18888 Q23280	aipr-1 daf-21 daf-41 p23	Caenorhabditis elegans
Asparagine N-linked glycosylation	C-type lectin domain-containing protein 87 C-type lectin domain-containing protein 88 C-type lectin domain-containing protein 91 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein	D3KFV8 H2KZ07 O18076 O45275 P91214 Q18821 Q1ZXU1 Q20665 Q21146 Q86NG3 Q94417 Q9N4W5 Q9XVS3 Q9XVT9 Q9XX56	CELE_F52E1.2 CELE_Y38H6C.8 clec-149 clec-196 clec-199 clec-202 clec-204 clec-224 clec-266 clec-45 clec-47 clec-86 clec-87 clec-88 clec-91 cpg-5 cpg-6	Caenorhabditis elegans
Aspartate and asparagine metabolism	Asparagine synthetase [glutamine-hydrolyzing] Aspartate aminotransferase, cytoplasmic Aspartate aminotransferase Glutamate carboxypeptidase 2 homolog N-acetylated-alpha-linked acidic dipeptidase 2 Probable calcium-binding mitochondrial carrier K02F3.2 asparaginase	O16924 P91406 Q17994 Q21153 Q22067 Q93332 Q9U3P0	C27A7.5 K02F3.2 asns-1 gcp-2.1 gcp-2.2 got-1 got-1.2 got-2.2	Caenorhabditis elegans
Aspirin ADME	3-ketosteroid oxygenase ABC transmembrane type-1 domain-containing protein Acetylcholinesterase 1 CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Contactin rig-6 Glycine N-acyltransferase-like protein Glycine N-acyltransferase-like protein Gut esterase 1 MFS domain-containing protein MFS domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Multidrug resistance protein mrp-7 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Organic cation transporter 1 Probable cytochrome P450 CYP36A1 Probable cytochrome P450 cyp-35D1 Putative transporter B0252.3 Putative transporter B0361.11 Solute carrier organic anion transporter family member Uncharacterized protein F23F12.3	A0A0K3AVV4 A0A0K3AWD3 A0A0M7RF98 A0A1C3NSL8 A0A238UKL7 G5ECD0 G5ECR3 G5EDA7 G5EDJ7 G5EE22 G5EEI9 G5EFP3 G5EGL6 H2KY69 H2KYS3 H2KZ60 H2L0E6 H2L0K7 H9G2Y9 O01302 O02627 O02628 O02641 O16220 O16362 O16482 O16670 O16671 O16673 O17328 O18247 O44649 O44650 O44651 O44652 O44655 O44656 O44657 O44658 O44704 O44706 O45364 O45659 O61204 O61935 O62377 O62378 P38433 P46499 P90771 P92016 Q04457 Q09617 Q10917 Q18613 Q18655 Q18795 Q19048 Q19442 Q20315 Q20943 Q21266 Q22008 Q22109 Q22371 Q22686 Q23268 Q23501 Q27465 Q27470 Q27471 Q27482 Q27499 Q3S1M2 Q4LDP0 Q4PIX1 Q7Z118 Q8MQ23 Q93550 Q93896 Q95ZT6 Q965T7 Q9BKR9 Q9N4Q4 Q9N5I1 Q9U2G5 Q9U539 Q9UAT3 Q9UAW9 Q9XW61 Q9XW75	B0252.3 B0361.11 C06H5.6 C44C10.3 C46C2.2 CELE_F21G4.1 CELE_F23F12.13 CELE_F43H9.4 CELE_F45E10.2 CELE_K05F1.6 CELE_K09E9.1 CELE_K11D9.3 CELE_T08B1.1 CELE_T10B10.4 CELE_T12B3.2 CELE_T22F7.1 CELE_Y57G11C.23 CELE_Y82E9BR.16 CELE_ZK892.3 F23F12.3/F23F12.1 ace-1 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 cyp-23A1 cyp-23a1 cyp-33A1 cyp-33B1 cyp-33C1 cyp-33C11 cyp-33C12 cyp-33C2 cyp-33C3 cyp-33C4 cyp-33C5 cyp-33C6 cyp-33C7 cyp-33C8 cyp-33C9 cyp-33D1 cyp-33D3 cyp-33E1 cyp-33E2 cyp-33E3 cyp-33a1 cyp-33b1 cyp-33c1 cyp-33c11 cyp-33c12 cyp-33c2 cyp-33c3 cyp-33c4 cyp-33c5 cyp-33c6 cyp-33c7 cyp-33c8 cyp-33c9 cyp-33d1 cyp-33d3 cyp-33e1 cyp-33e2 cyp-33e3 cyp-34A1 cyp-34A10 cyp-34A2 cyp-34A5 cyp-34A6 cyp-34A7 cyp-34A8 cyp-34A9 cyp-34a1 cyp-34a10 cyp-34a2 cyp-34a4 cyp-34a5 cyp-34a6 cyp-34a7 cyp-34a8 cyp-34a9 cyp-35A1 cyp-35A2 cyp-35A3 cyp-35A4 cyp-35A5 cyp-35B1 cyp-35B2 cyp-35B3 cyp-35C1 cyp-35a1 cyp-35a2 cyp-35a3 cyp-35a4 cyp-35a5 cyp-35b1 cyp-35b2 cyp-35b3 cyp-35c1 cyp-35d1 cyp-36A1 cyp36a1 dach-1 daf-9 ges-1 mct-1 mct-2 mct-3 mct-4 mct-5 mct-6 mrp-1 mrp-2 mrp-3 mrp-4 mrp-7 mrp-8 oct-1 oct-2 pes-23 rig-6 slcf-1 suex-2	Caenorhabditis elegans
Assembly of collagen fibrils and other multimeric structures	Fibronectin type-III domain-containing protein Putative cuticle collagen 99 VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein	G5EGA4 G5EGU7 O01545 O76368 O76836 Q18048 Q21394 Q9GZF5 Q9N5F6	C16E9.1 C18H7.1 C29A12.6 CELE_F31F7.2 CELE_K09E2.1 CELE_R193.2 CELE_T19D12.4 cle-1 col-99	Caenorhabditis elegans
Astrocytic Glutamate-Glutamine Uptake And Metabolism	Amino acid transporter Amino acid transporter Excitatory amino acid transporter Glutamine synthetase Probable glutamine synthetase Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 glutamine synthetase glutamine synthetase glutamine synthetase	O02225 O18210 P34497 Q10901 Q21353 Q21751 Q22682 Q95YD1 Q9U307 Q9UAY8 Q9XVU2	gln-1 gln-2 gln-3 gln-5 gln-6 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7	Caenorhabditis elegans
Asymmetric localization of PCP proteins	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Frizzled-2 Frizzled-4 LIM zinc-binding domain-containing protein MPN domain-containing protein PCI domain-containing protein Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein Wnt-2 Protein mom-5	A0A0K3AWM6 G5ECQ2 G5EDV1 H2KYA1 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P34889 P46502 P90868 P91477 Q04908 Q10920 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 cfz-2 cwn-2 lin-17 mom-5 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 prkl-1 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 wnt-2	Caenorhabditis elegans
Atorvastatin ADME	ABC transmembrane type-1 domain-containing protein Arylesterase Arylesterase Mechanosensory abnormality protein 6 Multidrug resistance protein mrp-7 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 PON (Paraoxonase) and MEC-6 Like SMP-30/Gluconolactonase/LRE-like region domain-containing protein Solute carrier organic anion transporter family member	B1V898 G5EFP3 O01811 Q19048 Q20943 Q21427 Q2V071 Q3S1M2 Q93550 Q966L1 Q9U2G5 Q9XW61	CELE_F21G4.1 mec-6 mrp-1 mrp-2 mrp-3 mrp-4 mrp-7 mrp-8 poml-1 poml-2 poml-3 poml-4	Caenorhabditis elegans
Autodegradation of the E3 ubiquitin ligase COP1	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 RING-type domain-containing protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P37165 P46502 P49632 P90868 P91477 Q04908 Q10920 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q965F9 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 par-2 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Azathioprine ADME	Equilibrative nucleoside transporter 3 Hypoxanthine phosphoribosyltransferase Inosine-5'-monophosphate dehydrogenase Multidrug resistance-associated protein 5 Multidrug resistance-associated protein lethal(2)03659 Nucleoside diphosphate kinase Probable GMP synthase [glutamine-hydrolyzing] Protein vav-1 Ras-related protein ced-10 Sodium/nucleoside cotransporter Sodium/nucleoside cotransporter guanylate kinase nucleoside-diphosphate kinase xanthine dehydrogenase	A0A131MBV2 G5EE72 G5EE77 O17892 P91425 Q03206 Q09580 Q19625 Q45FX5 Q7KX00 Q93576 Q93690 Q9GZH3 Q9NF11	CELE_Y48G8AL.15 CNT1 T22D1.3 ced-10 ent-6 ent-7 gmps-1 guk-1 hprt-1 mrp-5 mrp-6 ndk-1 rac-1 slc-28.1 slc-28.2 vav-1 xdh-1 xhd-1	Caenorhabditis elegans
BBSome-mediated cargo-targeting to cilium	ADP-ribosylation factor-like protein 6 Bardet-Biedl syndrome 1 protein homolog Bardet-Biedl syndrome 2 protein homolog Bardet-Biedl syndrome 4 protein homolog Bardet-Biedl syndrome 5 protein homolog Bardet-Biedl syndrome 7 protein homolog G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein GDP/GTP exchange factor Sec2 N-terminal domain-containing protein Neuropeptide receptor 18 Probable G-protein coupled receptor C06G4.5 Protein pthb1 homolog Tetratricopeptide repeat protein 8	A0A0K3AXD3 A0A3B1DQQ4 O01514 P34311 Q09502 Q18510 Q19640 Q20759 Q20841 Q21626 Q23033 Q23049 Q5CZ52 Q9N452 Q9NEZ7 Q9XW70	C06G4.5 CELE_F54C9.11 arl-6 bbs-1 bbs-2 bbs-4 bbs-5 bbs-7 bbs-8 bbs-9 npr-16 npr-18 npr-23 npr-24 npr-26 npr-28 osm-12	Caenorhabditis elegans
Basigin interactions	Caveolin-1 Caveolin-2 Contactin rig-6 Ig-like domain-containing protein Integrin alpha ina-1 MFS domain-containing protein MFS domain-containing protein MMP-like protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Peptidase metallopeptidase domain-containing protein Peptidyl-prolyl cis-trans isomerase 4 Peptidyl-prolyl cis-trans isomerase Probable sodium/potassium-transporting ATPase subunit beta-3 Sodium/potassium-transporting ATPase subunit beta-1 Sodium/potassium-transporting ATPase subunit beta Uncharacterized integrin beta-like protein C05D9.3 Uncharacterized protein	G5EBU3 G5ECC4 G5ECR3 G5EGM1 H2KZ60 H2L0E6 O17328 O17913 O44836 P52012 Q03600 Q18879 Q21182 Q22109 Q2L6V8 Q5WRR1 Q93235 Q93896 Q94051 Q9GYK2 Q9UAT3 Q9XUG9 Q9XUY5	C05D9.3 CELE_K03B8.6 CELE_T22F3.12 cav-1 cav-2 cyn-4 cyp-4 ina-1 mct-1 mct-2 mct-3 mct-4 mct-5 mct-6 mog-6 nkb-1 nkb-2 nkb-3 rig-6 slcf-1 wrk-1 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans
Bicarbonate transporters	Anion exchange protein Anion exchange protein	B3WFV9 Q58QG8	abts-1 abts-4	Caenorhabditis elegans
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Alpha-1,2-mannosyltransferase algn-9 Alpha-1,3/1,6-mannosyltransferase ALG2 Chitobiosyldiphosphodolichol beta-mannosyltransferase Dol-P-Man Dol-P-Man Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase Mannose-P-dolichol utilization defect 1 protein homolog N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase UDP-N-acetylglucosamine transferase subunit ALG14 homolog UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase	E5QCI3 P52887 P54002 P92012 Q09226 Q19265 Q20157 Q22797 Q23361 Q9U1Z2 U4PE03	algn-1 algn-12 algn-13 algn-14 algn-2 algn-3 algn-6 algn-7 algn-8 algn-9 hpo-16 hpo-17 mpdu-1	Caenorhabditis elegans
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	14-3-3-like protein 1 14-3-3-like protein 2 5'-3' exoribonuclease 1 C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein CCCH-type zinc finger protein moe-3 CCCH-type zinc finger protein oma-1 CCCH-type zinc finger protein oma-2 Exoribonuclease phosphorolytic domain-containing protein Exosome complex component CSL4 homolog Exosome complex component RRP4 homolog Exosome complex component RRP45 Exosome complex component RRP46 homolog MAP kinase-activated protein kinase mak-1 MAP kinase-activated protein kinase mak-2 Pharynx and intestine in excess protein 1 Probable exosome complex exonuclease RRP44 Putative exosome complex component RRP41 RNA-binding protein pos-1 Ribosomal RNA-processing protein 40 Ribosomal RNA-processing protein 42 Ribosomal RNA-processing protein 43 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Zinc finger protein mex-5 Zinc finger protein mex-6 m7GpppN-mRNA hydrolase dcap-2 mRNA-decapping enzyme 1	G5EC86 G5ECB9 G5EDS8 G5EF15 G5EG59 O18251 O45289 O45491 O45493 O62255 P41932 Q09436 Q17533 Q17632 Q17941 Q20128 Q20155 Q20655 Q21360 Q23359 Q93830 Q94131 Q95QG7 Q95XD0 Q965G5 Q9BHK7 Q9N363 Q9N4P9 Q9U1Y2 Q9U2V1 Q9U2V2 Q9U2V4 Q9XTG7 Q9XUB2 Q9XV46 Q9XXD2	C35D6.4 CELE_F38C2.7 CELE_Y116A8C.19 CELE_Y116A8C.20 CELE_Y60A9.3 akt-1 akt-2 ccch-1 ccch-2 ccch-5 crn-5 dcap-1 dcap-2 dcp-2 dct-13 dis-3 exos-1 exos-2 exos-3 exos-4.1 exos-4.2 exos-7 exos-8 exos-9 ftt-1 ftt-2 mak-1 mak-2 mex-1 mex-5 mex-6 moe-1 moe-2 moe-3 ndx-5 oma-1 oma-2 par-5 pic-1 pie-1 pos-1 xrn-1	Caenorhabditis elegans
CDK-mediated phosphorylation and removal of Cdc6	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 BRCT domain-containing protein Cell division control protein Cyclin-dependent kinase 2 G1/S-specific cyclin-E G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A0A131MD44 O01501 O16368 O17071 O17586 O44156 O61742 O61792 O61847 O62102 O76371 O76577 P0CG71 P34638 P37165 P46502 P49632 P90868 P91155 P91477 Q04908 Q10920 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q22253 Q22319 Q23237 Q23449 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	C14C10.5 CELE_F35G12.12 CELE_T07F10.5 CELE_T24A6.1 cdc-6 cdk-2 cya-1 cye-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
COPI-dependent Golgi-to-ER retrograde traffic	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 ADP-ribosylation factor Alpha-soluble NSF attachment protein Arf-GAP domain-containing protein Centromere/kinetochore protein zw10 homolog Coatomer subunit alpha Coatomer subunit beta Coatomer subunit epsilon DUF727 domain-containing protein E3 ubiquitin-protein ligase arc-1 ER lumen protein-retaining receptor erd-2.1 ER lumen protein-retaining receptor erd-2.2 GOLD domain-containing protein Gamma-soluble NSF attachment protein Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Kinesin heavy chain Kinesin light chain Kinesin light chain Kinesin motor domain-containing protein Kinesin motor domain-containing protein Kinesin-associated protein Kinesin-like protein klp-12 Kinesin-like protein klp-19 Kinesin-like protein klp-20 Kinesin-like protein unc-104 Kinesin-like protein unc-104 Kinesin-like protein vab-8 Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Kinesin-like protein Neuroblastoma-amplified sequence Probable coatomer subunit beta' Probable coatomer subunit delta Probable coatomer subunit gamma Probable coatomer subunit zeta RAB family Rac GTPase-activating protein 1 Suppressor/enhancer of lin-12 protein 9 Surfeit locus protein 4 homolog Transmembrane emp24 domain-containing protein bai Uncharacterized protein F07F6.4 Vesicle transport protein SEC20 Vesicle transport protein USE1 Vesicle-fusing ATPase Vesicle-trafficking protein SEC22b t-SNARE coiled-coil homology domain-containing protein	A0A4V0IKG7 C0Z1Y7 G5EBX0 G5ECF4 G5EEE6 G5EFK4 G5EFQ4 G5EGS3 G5EGS5 H9G2T2 O17528 O17901 O44738 O45935 O62246 O76413 P23678 P34540 P46822 P48583 P90841 P90904 P91400 Q09236 Q09473 Q09531 Q09654 Q10943 Q18864 Q18921 Q19633 Q19642 Q1RPT8 Q20168 Q20546 Q21441 Q22498 Q8MQ03 Q8MQ20 Q94231 Q94241 Q94392 Q965T6 Q9N4H7 Q9N598 Q9NEQ8 Q9TYL9 Q9UAQ6 Q9XU12 Q9XUS9	CELE_K02B12.7 CELE_Y59A8B.25 CELE_Y59A8B.8 F07F6.4 Y110A7A.11 arc-1 arf-1 arf-1.1 arf-1.2 arf-3 arf-5 arl-4 arl-6 bmk-1 copa-1 copb-1 copb-2 copd-1 cope-1 copg-1 copz-1 cyk-4 czw-1 erd-2 erd-2.1 erd-2.2 gbf-1 kap-1 khc-1 klc-1 klc-2 klp-11 klp-12 klp-13 klp-15 klp-18 klp-19 klp-20 klp-4 klp-6 klp-7 nsf-1 phi-34 rab-1 sec-20 sec-22 sel-9 sft-4 smgl-1 snap-1 surf-4 syx-18 tmed-10 tmed-3 unc-104 unc-116 vab-8 zen-4	Caenorhabditis elegans
COPI-independent Golgi-to-ER retrograde traffic	Actin-related protein 10 Actin Dynactin subunit 1 Dynactin subunit 4 Dynactin subunit 5 Dynactin subunit 6 Dynein heavy chain, cytoplasmic Dynein light chain 1, cytoplasmic Dynein light chain Dynein light chain Dynein light chain Dynein light chain Dynein light intermediate chain F-actin-capping protein subunit alpha F-actin-capping protein subunit beta Lissencephaly-1 homolog Polypeptide N-acetylgalactosaminyltransferase 3 Polypeptide N-acetylgalactosaminyltransferase 4 Probable dynactin subunit 2 Probable dynein light chain 2, cytoplasmic Protein bicaudal D homolog Rab3 GTPase-activating protein catalytic subunit Rab3 GTPase-activating protein regulatory subunit Ras-related protein Rab-18 Ras-related protein rab-6.1 Ras-related protein rab-6.2 WD_REPEATS_REGION domain-containing protein phospholipase A2	A0AAC1 E2JKZ0 G5ED34 O45087 P34213 P34678 P34685 P34686 Q09248 Q18194 Q19020 Q21557 Q22670 Q22782 Q22799 Q65XS9 Q7YTJ8 Q8I136 Q8MXS1 Q93538 Q95YD2 Q9GYR2 Q9N3F1 Q9N4I1 Q9NA98 Q9NDC9 Q9XWA8 V6CJ04	C45B2.6 arp-1 arp-11 bicd-1 cap-1 cap-2 dhc-1 dlc-1 dlc-2 dlc-3 dlc-4 dlc-5 dlc-6 dli-1 dnc-1 dnc-2 dnc-4 dnc-5 dnc-6 dyci-1 gly-3 gly-4 lis-1 pnm-1 rab-18 rab-6.1 rab-6.2 rbg-1 rbg-2	Caenorhabditis elegans

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