GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **126 - 150** of **499** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism
COPI-independent Golgi-to-ER retrograde traffic	Actin-related protein 10 Actin Dynactin subunit 1 Dynactin subunit 4 Dynactin subunit 5 Dynactin subunit 6 Dynein heavy chain, cytoplasmic Dynein light chain 1, cytoplasmic Dynein light chain Dynein light chain Dynein light chain Dynein light chain Dynein light intermediate chain F-actin-capping protein subunit alpha F-actin-capping protein subunit beta Lissencephaly-1 homolog Polypeptide N-acetylgalactosaminyltransferase 3 Polypeptide N-acetylgalactosaminyltransferase 4 Probable dynactin subunit 2 Probable dynein light chain 2, cytoplasmic Protein bicaudal D homolog Rab3 GTPase-activating protein catalytic subunit Rab3 GTPase-activating protein regulatory subunit Ras-related protein Rab-18 Ras-related protein rab-6.1 Ras-related protein rab-6.2 WD_REPEATS_REGION domain-containing protein phospholipase A2	A0AAC1 E2JKZ0 G5ED34 O45087 P34213 P34678 P34685 P34686 Q09248 Q18194 Q19020 Q21557 Q22670 Q22782 Q22799 Q65XS9 Q7YTJ8 Q8I136 Q8MXS1 Q93538 Q95YD2 Q9GYR2 Q9N3F1 Q9N4I1 Q9NA98 Q9NDC9 Q9XWA8 V6CJ04	C45B2.6 arp-1 arp-11 bicd-1 cap-1 cap-2 dhc-1 dlc-1 dlc-2 dlc-3 dlc-4 dlc-5 dlc-6 dli-1 dnc-1 dnc-2 dnc-4 dnc-5 dnc-6 dyci-1 gly-3 gly-4 lis-1 pnm-1 rab-18 rab-6.1 rab-6.2 rbg-1 rbg-2	Caenorhabditis elegans
Acyl chain remodelling of PI	C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Lysophospholipid acyltransferase 7 Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2	G4RY15 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q18339 Q19468 Q22591 Q3V5J7 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 CELE_Y69A2AL.2 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 lpiat mboa-7 tag-289	Caenorhabditis elegans
GABA synthesis, release, reuptake and degradation	Acetylcholine regulator unc-18 Glutamate decarboxylase 1 Heat shock protein hsp-1 J domain-containing protein Putative complexin-1 Rab-3-interacting molecule unc-10 Ras-related protein Rab-3 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Synaptotagmin-1 Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Vesicular GABA transporter t-SNARE protein aex-4	A5PEW5 E5QCE7 G5EBK2 G5EDB7 G5EEN8 O02495 O16000 P09446 P34351 P34579 P34693 P34815 Q19767 Q22366 Q94057 Q94986 Q95XH1 Q9GUM7	aex-4 cpx-1 dnj-14 hsp-1 hsp70a lan-2 rab-3 ric-4 snb-1 snb-2 snb-5 snb-6 snb-7 snt-1 tag-81 unc-10 unc-18 unc-25 unc-47 unc-64 vamp-7	Caenorhabditis elegans
Inactivation, recovery and regulation of the phototransduction cascade	Beta-arrestin arr-1 Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-gated cation channel EF-hand domain-containing protein G protein-coupled receptor kinase 1 G-protein coupled receptors family 1 profile domain-containing protein Guanine nucleotide-binding protein subunit gamma Neuronal calcium sensor 2 Protein farnesyltransferase subunit beta Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Receptor-type guanylate cyclase daf-11 Receptor-type guanylate cyclase gcy-10 Receptor-type guanylate cyclase gcy-11 Receptor-type guanylate cyclase gcy-12 Receptor-type guanylate cyclase gcy-13 Receptor-type guanylate cyclase gcy-14 Receptor-type guanylate cyclase gcy-15 Receptor-type guanylate cyclase gcy-17 Receptor-type guanylate cyclase gcy-18 Receptor-type guanylate cyclase gcy-19 Receptor-type guanylate cyclase gcy-1 Receptor-type guanylate cyclase gcy-20 Receptor-type guanylate cyclase gcy-21 Receptor-type guanylate cyclase gcy-22 Receptor-type guanylate cyclase gcy-23 Receptor-type guanylate cyclase gcy-25 Receptor-type guanylate cyclase gcy-27 Receptor-type guanylate cyclase gcy-29 Receptor-type guanylate cyclase gcy-2 Receptor-type guanylate cyclase gcy-3 Receptor-type guanylate cyclase gcy-4 Receptor-type guanylate cyclase gcy-5 Receptor-type guanylate cyclase gcy-6 Receptor-type guanylate cyclase gcy-7 Receptor-type guanylate cyclase gcy-8 Receptor-type guanylate cyclase gcy-9 Serine/threonine-protein phosphatase with EF-hands pef-1	A0A078BQP2 A8WI01 B1Q257 E7EAU8 G5EBX9 G5EEE2 G5EEE9 G5EFQ0 H2L002 N1NVB7 O01818 O16544 O16715 O44501 O61827 O62026 O62179 P36609 P51485 P54406 P91550 Q03611 Q09435 Q09537 Q10028 Q10029 Q18136 Q18331 Q19187 Q19752 Q19768 Q23310 Q23681 Q23682 Q7Z205 Q8I4N4 Q9GYQ4 Q9N4C1 Q9XTY1 Q9XU42 X5M8U1	CELE_F57C9.6 arr-1 cal-5 che-6 cng-1 cng-2 cng-3 daf-11 fnta-1 fntb-1 gcy-1 gcy-10 gcy-11 gcy-12 gcy-13 gcy-14 gcy-15 gcy-16 gcy-17 gcy-18 gcy-19 gcy-2 gcy-20 gcy-21 gcy-22 gcy-23 gcy-25 gcy-27 gcy-29 gcy-3 gcy-4 gcy-5 gcy-6 gcy-7 gcy-8 gcy-9 gpc-1 grk-1 ncs-2 odr-1 pef-1 tax-2 tax-4	Caenorhabditis elegans
SHC-mediated cascade:FGFR3	EGL-17 Myoblast growth factor receptor egl-15 Protein let-756 Ras protein let-60 Sex muscle abnormal protein 5 Son of sevenless homolog	G5EEF1 P22981 P29355 Q10656 Q11184 Q9N5D3	egl-15 egl-17 let-341 let-60 let-756 lin-34 sem-5 sos-1	Caenorhabditis elegans
FGFR2 alternative splicing	DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 2 Heterogeneous nuclear ribonucleoprotein A1 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Putative RNA-binding protein PTB-1a Putative RNA-binding protein R05D3.8 RNA polymerase Rpb4/RPC9 core domain-containing protein RRM domain-containing protein Transcription initiation factor IIF subunit alpha	O01763 O02092 P16356 P34541 Q10578 Q17558 Q17684 Q18999 Q19826 Q22037 Q4W5P0 Q8MYM8 Q93338 Q93594 Q965S0 Q9GR61 Q9N3C9 Q9N5K2 Q9U3I0 Q9XVH6	R05D3.8 ama-1 cbp-20 cbp-80 gtf-2F1 gtf-2F2 gtf-2f1 gtf-2f2 hrp-1 ncbp-1 ncbp-2 ptb-1 rbp-1 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 sqd-1	Caenorhabditis elegans
p53-Dependent G1 DNA Damage Response	BRCT domain-containing protein Cyclin-dependent kinase 2 Cyclin-dependent kinase inhibitor G1/S-specific cyclin-E G2/mitotic-specific cyclin-A1 GNAT family N-acetyltransferase	A0A131MD44 G5EEJ2 O01501 O61847 P34638 Q22319	CELE_T07F10.5 CELE_T24A6.1 cdk-2 cki-2 cya-1 cye-1	Caenorhabditis elegans
Negative regulation of FGFR1 signaling	EGL-17 Glycoside hydrolase family 1 protein Glycoside hydrolase family 1 protein Mitogen-activated protein kinase mpk-1 Myoblast growth factor receptor egl-15 Protein let-756 WAP-type 'four-disulfide core	G5EDX1 G5EEF1 P39745 Q10656 Q11184 Q18758 Q9TZA0	egl-15 egl-17 kal-1 klo-1 klo-2 let-756 mpk-1 sur-1	Caenorhabditis elegans
PTK6 Down-Regulation	Protein kinase domain-containing protein Protein nipi-4 Tyrosine-protein kinase	A0A4V0IL59 O16262 Q9N3S5	CELE_Y47G6A.5 nipi-4 trk-1	Caenorhabditis elegans
Vitamin B2 (riboflavin) metabolism	Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 Probable FAD synthase Riboflavin transporter rft-1 Riboflavin transporter rft-2 Tartrate-resistant acid phosphatase type 5 riboflavin kinase	G4SDH4 O01320 P90754 P90755 Q21918 Q22017 Q3LFN0	C27A7.1 C27A7.3 CELE_F02E9.7 flad-1 rfk-1 rft-1 rft-2	Caenorhabditis elegans
RAC3 GTPase cycle	Amino acid transporter Amino acid transporter Arf-GAP domain-containing protein CRAL-TRIO domain-containing protein Cadherin-4 Caveolin-1 Caveolin-2 Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein homolog DH domain-containing protein DH domain-containing protein Ephrin receptor 1 Excitatory amino acid transporter GTPase-activating protein pac-1 Glutamate carboxypeptidase 2 homolog MAGUK family Membrane-associated protein gex-3 N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Phosphoinositide 3-kinase adapter subunit Probable rho GDP-dissociation inhibitor Protein BRICK1 Protein let-99 Protein unc-112 Protein vav-1 Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 Rac GTPase-activating protein 1 Rap guanine nucleotide exchange factor 1 Ras-related protein Rab-7a Ras-related protein ced-10 Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho GTPase-activating protein syd-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein Rho-GAP domain-containing protein SH3 domain-containing protein Serine/threonine-protein kinase SULU Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Synaptobrevin-1 Synaptosomal-associated protein Target of ERK kinase mpk-1 Tyrosine-protein kinase abl-1 Uncharacterized integrin beta-like protein C05D9.3 Vang-like protein WAPL domain-containing protein WW domain-containing protein tag-325 Wiskott-Aldrich syndrome protein family member t-SNARE protein aex-4	A0A0K3AR51 A0A2K5AU23 A5PEW5 A5Z2X2 G5EDP9 G5EEN8 G5EFU0 G5EGQ3 H2KY90 H2KYI7 H2KZH5 H2KZV4 H2KZV6 H2KZX7 O01443 O01847 O02495 O17590 O18210 O44518 O45611 O61460 O61528 P03949 P34288 P46549 P46941 P55163 P91406 Q03206 Q05062 Q10901 Q10929 Q17850 Q18685 Q18879 Q19319 Q19370 Q19467 Q20496 Q21341 Q21353 Q21751 Q22682 Q23130 Q23146 Q45FX5 Q7JP75 Q86NH1 Q93332 Q94051 Q95XW5 Q9GYK2 Q9UAY8 Q9XUS9 Q9XVK6	C05D9.3 CELE_F22G12.5 CELE_F23H11.4 CELE_T04C9.1 CELE_Y34B4A.4 CELE_Y57G11C.1147 aap-1 abi-1 abl-1 aex-4 cav-1 cav-2 cdc-42 cdh-4 ced-10 cgef-1 cyk-1 cyk-4 gap gcp-2.1 gcp-2.2 gex-2 gex-3 git-1 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7 kin-18 let-99 magu-1 max-2 ocrl-1 pac-1 pak-1 pak-2 rab-7 rac-1 rga-1 rga-5 rga-6 rga-8 rhi-1 ric-4 snb-1 srgp-1 sulu syd-1 tag-325 tag-81 tiam-1 toe-2 unc-112 unc-73 vab-1 vang-1 vav-1 wve-1	Caenorhabditis elegans
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Cullin-2 Elongin-C Hypoxia-inducible factor 1 Hypoxia-inducible factor prolyl hydroxylase MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 RING-box protein 1 RNA polymerase II transcription factor SIII p18 subunit Ubiquitin-conjugating enzyme E2 2 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein von Hippel-Lindau tumor suppressor homolog	G5EBV0 G5ECR7 G5EGD2 O16368 O17071 O17586 O44156 O61742 O61792 O62102 O76371 O76577 P0CG71 P35129 P37165 P46502 P49632 P90868 P91477 Q04908 Q10920 Q17390 Q17971 Q18115 Q18787 Q19213 Q19324 Q20058 Q20585 Q20938 Q22253 Q23237 Q23449 Q23457 Q27488 Q95005 Q95008 Q95PZ7 Q966I8 Q9BKS1 Q9GZH5 Q9N599 Q9XTT9 Q9XUV0	3L686 C14C10.5 CELE_F35G12.12 ccd-3 cul-2 div-3 egl-9 elb-1 elc-1 hif-1 let-70 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 ubc-2 ubia ubib ubl-1 ubq-1 ubq-2 vhl-1	Caenorhabditis elegans
FGFR4 ligand binding and activation	EGL-17 Myoblast growth factor receptor egl-15 Protein let-756	G5EEF1 Q10656 Q11184	egl-15 egl-17 let-756	Caenorhabditis elegans
PLC beta mediated events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Guanine nucleotide-binding protein subunit alpha	G5EBH0 G5EGU1	egl-30 egl-8	Caenorhabditis elegans
TP53 Regulates Metabolic Genes	5'-AMP-activated protein kinase catalytic subunit alpha-1 5'-AMP-activated protein kinase catalytic subunit alpha-2 Association with the SNF1 complex (ASC) domain-containing protein Association with the SNF1 complex (ASC) domain-containing protein CBS domain-containing protein CBS domain-containing protein CBS domain-containing protein CBS domain-containing protein CBS domain-containing protein DAF-15 GTP-binding protein Rheb homolog 1 GTP-binding protein Glucose-6-phosphate 1-dehydrogenase Glucose-6-phosphate isomerase Glutathione reductase, mitochondrial Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Peroxiredoxin prdx-2 Putative glutaminase 2 Putative glutaminase 3 Ragulator complex protein LAMTOR2 homolog Ras-related GTP-binding protein C Sestrin homolog Sodium-coupled neutral amino acid transporter 9 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog Thioredoxin reductase 1 Thioredoxin-1 glutaminase	A0A0K3AUJ9 A0A1T5HUK9 G5EGB3 H2L0K0 O02168 O17268 P34443 P45894 P91040 Q09433 Q17745 Q19013 Q19425 Q22743 Q27464 Q68TI8 Q7K707 Q8I112 Q8WQG5 Q93379 Q93650 Q95Q95 Q95ZQ4 Q9N2U6 Q9N4D6 Q9N501 Q9NAH7 Q9XUY2 U4PRW7	CeTor F13H10.3 aak-1 aak-2 aakb-1 aakb-2 aakg-1 aakg-2 aakg-3 aakg-4 aakg-5 daf-15 glna-1 glna-2 glna-3 gpi-1 gspd-1 gsr-1 let-363 lmtr-2 lmtr-3 lmtr-5 mlst-8 prdx-2 prx2 raga-1 ragc-1 rheb-1 sesn-1 tag-56 trx-1 trxr-1	Caenorhabditis elegans
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	14-3-3-like protein 1 14-3-3-like protein 2 5'-3' exoribonuclease 1 C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein C3H1-type domain-containing protein CCCH-type zinc finger protein moe-3 CCCH-type zinc finger protein oma-1 CCCH-type zinc finger protein oma-2 Exoribonuclease phosphorolytic domain-containing protein Exosome complex component CSL4 homolog Exosome complex component RRP4 homolog Exosome complex component RRP45 Exosome complex component RRP46 homolog Importin N-terminal domain-containing protein MAP kinase-activated protein kinase mak-1 MAP kinase-activated protein kinase mak-2 Pharynx and intestine in excess protein 1 Probable exosome complex exonuclease RRP44 Putative exosome complex component RRP41 RNA-binding protein pos-1 Ribosomal RNA-processing protein 40 Ribosomal RNA-processing protein 42 Ribosomal RNA-processing protein 43 Zinc finger protein mex-5 Zinc finger protein mex-6 m7GpppN-mRNA hydrolase dcap-2 mRNA-decapping enzyme 1	A0A131MBF9 G5EC86 G5ECB9 G5EDS8 G5EF15 G5EG59 O18251 O45289 O45491 O45493 O62255 P41932 Q09436 Q17533 Q17632 Q20128 Q20155 Q20655 Q21360 Q23359 Q93830 Q94131 Q95QG7 Q95XD0 Q965G5 Q9BHK7 Q9N363 Q9N4P9 Q9U1Y2 Q9U2V1 Q9U2V2 Q9U2V4 Q9XUB2 Q9XV46 Q9XXD2	C35D6.4 CELE_F38C2.7 CELE_Y116A8C.19 CELE_Y116A8C.20 CELE_Y60A9.3 ccch-1 ccch-2 ccch-5 crn-5 dcap-1 dcap-2 dcp-2 dct-13 dis-3 exos-1 exos-2 exos-3 exos-4.1 exos-4.2 exos-7 exos-8 exos-9 ftt-1 ftt-2 imb-2 mak-1 mak-2 mex-1 mex-5 mex-6 moe-1 moe-2 moe-3 ndx-5 oma-1 oma-2 par-5 pic-1 pie-1 pos-1 xrn-1	Caenorhabditis elegans
Dissolution of Fibrin Clot	Kringle domain-containing protein SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein	A9Z1L1 G5ECY2 G5EE40 G5EFH4 O17365 O45520 P91823 Q18287 Q19651 Q9XVQ1	C28G1.2 CELE_F15D3.4 CELE_F44G3.7 CELE_T22A3.6 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8	Caenorhabditis elegans
Sema4D mediated inhibition of cell attachment and migration	GTP binding protein Plexin-2 Protein kinase domain-containing protein Ras-like GTP-binding protein rhoA Ras-related protein ced-10 Rho-GAP domain-containing protein Sema domain-containing protein Semaphorin-1A Semaphorin-2A Tyrosine-protein kinase receptor svh-2	G5EBK8 H2KZU7 O45611 O45657 Q03206 Q17330 Q22038 Q95XP4 Q9TYS4 Q9XVQ7	CELE_F11E6.8 R-ras1 ced-10 mab-20 plx-2 rac-1 ras-1 ras1 rga-5 rho-1 rhoa sema-1a smp-1 smp-2 svh-2	Caenorhabditis elegans
Assembly of collagen fibrils and other multimeric structures	Fibronectin type-III domain-containing protein Putative cuticle collagen 99 VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein	G5EGA4 G5EGU7 O01545 O76368 O76836 Q18048 Q21394 Q9GZF5 Q9N5F6	C16E9.1 C18H7.1 C29A12.6 CELE_F31F7.2 CELE_K09E2.1 CELE_R193.2 CELE_T19D12.4 cle-1 col-99	Caenorhabditis elegans
Physiological factors	Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Gut esterase 1 NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family NEPrilysin metallopeptidase family Neprilysin-11 Neprilysin-1 Neprilysin-21 Neprilysin-2 Neprilysin Neprilysin Neprilysin Neprilysin Neprilysin Peptidase M13 C-terminal domain-containing protein Peptidase M13 C-terminal domain-containing protein Peptidase M13 N-terminal domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13 domain-containing protein Peptidase_M13_N domain-containing protein	A0A131MCS3 A0A1C3NSL8 A0A5S9MNU9 G5ED52 G5EDJ7 H2KYL1 H2KZE5 H2L0K7 H9G2Y9 O01302 O16607 O16636 O16652 O16789 O16790 O16795 O16796 O44857 O45311 O45569 P92016 Q04457 Q18673 Q21266 Q22008 Q22523 Q22763 Q23268 Q23427 Q400M1 Q4LDP0 Q8MQ23 Q9U2T0 Q9U2T1 Q9XW75	CELE_F41C6.4 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 ges-1 nep-1 nep-10 nep-11 nep-12 nep-13 nep-16 nep-17 nep-18 nep-2 nep-20 nep-21 nep-22 nep-23 nep-24 nep-25 nep-26 nep-3 nep-4 nep-6 nep-8 nep-9	Caenorhabditis elegans
HDL remodeling	PhosphoLipase A2 Group	Q21515	plag-15	Caenorhabditis elegans
APAP ADME	3-ketosteroid oxygenase ABC transmembrane type-1 domain-containing protein ABC transporter domain-containing protein ABC transporter family G domain-containing protein CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family Gamma-glutamyltransferase Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Glucuronosyltransferase Glutathione S-transferase P Multidrug resistance protein mrp-7 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 5 Multidrug resistance-associated protein lethal(2)03659 N-acyl-aliphatic-L-amino acid amidohydrolase Peptidase M20 dimerisation domain-containing protein Probable cytochrome P450 CYP36A1 Probable cytochrome P450 cyp-35D1	A0A0M7RF98 A0A486WVP7 B5BM47 D7SFK1 G5ECD0 G5EE22 G5EE72 G5EFP3 H2KY69 H2KYS3 H2L030 H2L0B7 O02627 O02628 O02641 O16220 O16362 O16482 O16670 O16671 O16673 O18000 O18256 O44649 O44650 O44651 O44652 O44655 O44656 O44657 O44658 O44704 O44706 O45364 O45659 O61204 O61935 O62377 O62378 P10299 P90771 Q19048 Q19082 Q19585 Q19625 Q20315 Q20943 Q27465 Q27470 Q27471 Q27482 Q27499 Q3S1M2 Q5WRS4 Q965T7 Q9N4Q4 Q9N5I1 Q9N5V4 Q9U2G5 Q9XW61	C06A6.4 C53D5.5 CELE_H14N18.4 CELE_T03D8.6 CELE_T19H12.6 CELE_Y7A9A.1 CELE_Y97E10AR.2 abcx-1 cyp-23A1 cyp-23a1 cyp-33A1 cyp-33B1 cyp-33C1 cyp-33C11 cyp-33C12 cyp-33C2 cyp-33C3 cyp-33C4 cyp-33C5 cyp-33C6 cyp-33C7 cyp-33C8 cyp-33C9 cyp-33D1 cyp-33D3 cyp-33E1 cyp-33E2 cyp-33E3 cyp-33a1 cyp-33b1 cyp-33c1 cyp-33c11 cyp-33c12 cyp-33c2 cyp-33c3 cyp-33c4 cyp-33c5 cyp-33c6 cyp-33c7 cyp-33c8 cyp-33c9 cyp-33d1 cyp-33d3 cyp-33e1 cyp-33e2 cyp-33e3 cyp-34A1 cyp-34A10 cyp-34A2 cyp-34A5 cyp-34A6 cyp-34A7 cyp-34A8 cyp-34A9 cyp-34a1 cyp-34a10 cyp-34a2 cyp-34a4 cyp-34a5 cyp-34a6 cyp-34a7 cyp-34a8 cyp-34a9 cyp-35A1 cyp-35A2 cyp-35A3 cyp-35A4 cyp-35A5 cyp-35B1 cyp-35B2 cyp-35B3 cyp-35C1 cyp-35a1 cyp-35a2 cyp-35a3 cyp-35a4 cyp-35a5 cyp-35b1 cyp-35b2 cyp-35b3 cyp-35c1 cyp-35d1 cyp-36A1 cyp36a1 dach-1 daf-9 gst-1 mrp-1 mrp-2 mrp-3 mrp-4 mrp-5 mrp-6 mrp-7 mrp-8 pes-9 ugt-57 wht-5	Caenorhabditis elegans
Neurotransmitter clearance	Acetylcholinesterase 1 Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylesterase type B domain-containing protein Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Carboxylic ester hydrolase Gut esterase 1 Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Organic cation transporter 1 Putative transporter B0252.3 Putative transporter B0361.11 Uncharacterized protein F23F12.3	A0A0K3AVV4 A0A0K3AWD3 A0A1C3NSL8 A0A238UKL7 G5EDA7 G5EDJ7 G5EEI9 G5EGL6 H2L0K7 H9G2Y9 O01302 O18247 P38433 P46499 P92016 Q04457 Q09617 Q10917 Q18613 Q18655 Q18795 Q19442 Q21266 Q22008 Q22686 Q23268 Q23501 Q4LDP0 Q4PIX1 Q7Z118 Q8MQ23 Q9BKR9 Q9U539 Q9UAW9 Q9XW75	B0252.3 B0361.11 C06H5.6 C44C10.3 C46C2.2 CELE_F23F12.13 CELE_F45E10.2 CELE_K05F1.6 CELE_K09E9.1 CELE_K11D9.3 CELE_T08B1.1 CELE_T12B3.2 CELE_T22F7.1 CELE_Y57G11C.23 CELE_Y82E9BR.16 CELE_ZK892.3 F23F12.3/F23F12.1 ace-1 cest-1 cest-1.1 cest-1.2 cest-12 cest-13 cest-16 cest-17 cest-19 cest-2.1 cest-2.2 cest-2.3 cest-24 cest-26 ges-1 oct-1 oct-2 pes-23 suex-2	Caenorhabditis elegans
Growth hormone receptor signaling	Fibronectin type-III domain-containing protein	Q9UB28	let-805	Caenorhabditis elegans
MET activates STAT3	Kringle domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Signal transducer and activator of transcription 1 Signal transducer and activator of transcription b Tyrosine-protein kinase receptor svh-2	D3YT30 H2KZU7 P91823 Q20977 Q9NAD6 Q9XVQ7	CELE_F11E6.8 CELE_T12G3.2 CELE_T22A3.6 sta-1 sta-2 stat-b svh-2	Caenorhabditis elegans

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