GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **51 - 75** of **252** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism	GlyTouCan ID
RND1 GTPase cycle	Aldehyde dehydrogenase Carboxypeptidase D Caveolin Desmoplakin-A Family with sequence similarity 83 member B Fibroblast growth factor receptor substrate 2 Flotillin-2a Kinase D-interacting substrate of 220 kDa B Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Plexin-A1 Protein HEG RAS-related 2 RNA binding motif protein 39b isoform X1 RNA-binding motif protein 39a Ras-like protein Rnd1a Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Stathmin Stress-induced-phosphoprotein 1 Transferrin receptor protein 1 Transmembrane protein 59 Uncharacterized protein LOC795037 Vang-like protein 2 Vang-like protein receptor protein-tyrosine kinase	A0A8M2BID5 A8IYK2 A9JRX6 B0S6V7 B0V210 B3DHG9 B3DHJ4 E7F020 E7F254 E7F4Q7 E7F8G5 F1R372 Q4VBT7 Q52WX7 Q568M0 Q58ER0 Q5MPX4 Q5RKM3 Q6NZS1 Q6R8J2 Q6YLH9 Q7T163 Q803H1 Q8UVJ6 Q90ZZ8 Q98TZ8	Aldh-III CAV1 LOC100004299 aldh3a2 aldh3a2a arhgap35a arhgap5 arms cav1 cpda dspa epha2 epha2a fam83b fb36h09 fi33b05 flot2a frs3 heg id:ibd5152 im:6911394 kidins220 kidins220b pik3r1 pik3r2 plxna1 plxna1b rbm39a rbm39b rnd1a rnd1b rnd1l rnpc2 rnpc2l rras2 rtk6 scg10 scgn10 si:dkey-181m9.10 stb2 stbm stip1 stmn2 stmn2b tfr1a tmem59 tri vangl1 vangl2 wu:fa97g07 wu:fb09c08 wu:fb36h09 wu:fb65b05 wu:fc06b11 wu:fc07c04 wu:fc47b08 wu:fi33b05 wu:fk50c04 zgc:110132 zgc:110215 zgc:112139 zgc:113117 zgc:153089 zgc:194621 zgc:55780 zgc:92064 zgc:92133	Danio rerio (zebrafish)
RND3 GTPase cycle	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 Carboxypeptidase D Caveolin Cytoskeleton-associated protein 4 Desmoglein-2.1 Desmoplakin-A Family with sequence similarity 83 member B Flotillin-2a Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Protein HEG Protein scribble homolog RNA binding motif protein 39b isoform X1 RNA helicase RNA-binding motif protein 39a Rho GTPase-activating protein 35 Rho GTPase-activating protein 5 Rho-related GTP-binding protein RhoE Tropomodulin-2 Vang-like protein 2 Vang-like protein creatine kinase receptor protein-tyrosine kinase	A0A8M2BID5 A9ULR9 B0S6V7 B0V210 B3DHG9 E7F254 E7F4Q7 E7F8G5 F1R372 F1R5K5 H2EQR6 O42107 Q4H4B6 Q58ER0 Q66I39 Q6NW47 Q6NZS1 Q6PC71 Q6R8J2 Q6YLH9 Q803H1 Q8AY63 Q8UVJ6 Q98TZ8	CAV1 LOC100004299 arhe arhgap35a arhgap5 bck cav1 cb594 ckap4 ckb ckbb cpda ddx4 dsg2 dsg2.1 dsga dspa epha2 epha2a fam83b fc39h07 flot2a heg id:ibd2712 id:ibd2919 id:ibd5152 kctd13 llk pik3r1 pik3r2 rbm39a rbm39b rho8 rnd3 rnd3a rnpc2 rnpc2l rtk6 scrb1 scrib stb2 stbm tmod2 tnfaip1 tri vangl1 vangl2 vas vasa vlg wu:fa97g07 wu:fb09c08 wu:fb65b05 wu:fc07c04 wu:fc39h07 wu:fi06b02 wu:fi24g05 wu:fj36f10 wu:fj37d11 zgc:109812 zgc:112139 zgc:113117 zgc:158535 zgc:55302 zgc:55780 zgc:73080 zgc:86648	Danio rerio (zebrafish)
Formation of the cornified envelope	Desmocollin 2-like protein Desmoglein-2.1 Desmoplakin-A Junction plakoglobin a Lipase Plakophilin 3a Plakophilin-2	A0A8M2BID5 B0BF33 F1Q8J9 F1QSQ0 H2EQR6 Q7ZTR9 Q9PVF7	cb80 dsc dsc2 dsc2l dsg2 dsg2.1 dsga dspa fb73g06 jup jupa lipf pkp2 pkp3 pkp3a wu:fa97f09 wu:fb73g06 wu:fk69a12 zgc:136656 zgc:56632	Danio rerio (zebrafish)
Apoptotic cleavage of cell adhesion proteins	Cadherin-1 Caspase-3 Catenin beta-1 Desmoglein-2.1 Desmoplakin-A Occludin	A0A8M2BID5 F1QGH7 F1R799 H2EQR6 Q90Z37 Q98UI8	E-cad casp3 casp3a cdh1 ctnnb1 dsg2 dsg2.1 dsga dspa ocln oclna wu:fd23h10 wu:fi13c01 zgc:100890 zgc:113992 zgc:56359	Danio rerio (zebrafish)
PCP/CE pathway	Disheveled-associated activator of morphogenesis 1 Dishevelled, dsh homolog 2 (Drosophila) Frizzled 7b Frizzled class receptor 3b Frizzled-1 Frizzled-6 Profilin Profilin Profilin Protein Wnt-1 Protein Wnt-4a Protein Wnt-5b Protein Wnt Rac family small GTPase 2 Rac family small GTPase 3a Rac family small GTPase 3b Ras-related C3 botulinum toxin substrate 1 Rho-related GTP-binding protein RhoA-C	A0JBX4 A1BPR0 A9JRY8 B3DJ49 E7F0A1 P24257 P47793 Q5RHJ3 Q6AZA1 Q6DGB7 Q6IQN5 Q6P0Y7 Q7T2E8 Q7ZSZ9 Q802D5 Q803Q5 Q90ZT3 Q92050	daam1b daam1l dvl2 fa91a03 fc83b10 frizzled3b fz10 fz3 fz7 fzd1 fzd3b fzd3l fzd6 fzd7a hm:zeh0341 id:ibd2735 int-1 pfn1 pfn2 pfn2a pfn2b pfn2l rac1 rac1a rac2 rac3 rac3a rac3b rhoac sb:cb813 sb:eu471 si:ch211-87i20.1 wnt-1 wnt-4 wnt-5 wnt1 wnt4 wnt4a wnt5 wnt5a wnt5b wu:fa91a03 wu:fb01g08 wu:fb02e10 wu:fb54f09 wu:fb95b01 wu:fc05d12 wu:fc17e10 wu:fc83b10 wu:fd16e02 wu:fd58f06 wu:fi35b08 wu:fo71e09 wu:fp54a02 zg03 zg07 zg10 zgc:100831 zgc:194774 zgc:55372 zgc:55823 zgc:55917 zgc:65879 zgc:77440 zgc:86686 zgc:86790 zgc:86934	Danio rerio (zebrafish)
Glycosphingolipid biosynthesis	2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor Beta-1,4 N-acetylgalactosaminyltransferase Beta-1,4-galactosyltransferase 5 Beta-1,4-galactosyltransferase Galactose-3-O-sulfotransferase 1a Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A Lactosylceramide alpha-2,3-sialyltransferase ceramide glucosyltransferase	A0JMC3 A1L229 A2BGH3 Q1ECX6 Q3YL68 Q501W7 Q7T3S5 Q802Y5	B4GALNT1 b3gnt5 b3gnt5a b4galnt1a b4galt5 b4galt6 cb539 gal3st1 gal3st1a sb:cb539 si:dkey-189j19.2 si:dkeyp-86g2.2 st3Gal-V st3gal5 ugcg ugt8 wu:fc08a12 zgc:112506 zgc:158609 zgc:55730	Danio rerio (zebrafish)
Stimuli-sensing channels	Acid-sensing ion channel 1A Acid-sensing ion channel 1B Acid-sensing ion channel 1C Acid-sensing ion channel 2 Acid-sensing ion channel 4-A Anoctamin-10 Chloride channel 2c Chloride channel protein Protein tweety homolog 2-like Protein tweety homolog 3 Stomatin (EPB72)-like 3a Two pore channel protein 2 Uncharacterized protein LOC550523	A0JMD4 A5PLE0 E7FCE2 Q08BG8 Q32LT7 Q4V8U5 Q568N1 Q6NUZ2 Q708S4 Q708S5 Q708S6 Q708S7 Q708S8	accn1 accn2a accn2b accn2c accn4a ano10 asic1a asic1b asic1c asic2 asic4a clcn2c clcn4 im:6903943 si:ch211-229n1.3 stoml3 stoml3a stoml3b tmem16k tpc2 tpcn2 ttyh2l ttyh3b zgc:110200	Danio rerio (zebrafish)
Degradation of the extracellular matrix	72 kDa type IV collagenase Brevican core protein Cadherin-1 Calpain 1, (mu/I) large subunit a Calpain small subunit 1 Calpain, small subunit 1 b Calpain-1 catalytic subunit-like isoform X1 Calpain-1 catalytic subunit Calpain-2 catalytic subunit Calpain-5 Calpain-7 Calpain-9 Cathepsin K Cathepsin L.1 Cathepsin L1-like precursor Decorin Im Im Matrix metalloproteinase 14 (Membrane-inserted) alpha Matrix metalloproteinase-9 Spp1 Stromelysin-2 precursor Uncharacterized protein LOC100136837 Uncharacterized protein LOC559822 Uncharacterized protein LOC567623 precursor Uncharacterized protein LOC678524 isoform X1 Uncharacterized protein LOC793035 precursor	A0JMG3 A4JYN2 A4QNV6 A7MBX1 A7MCR6 A8E588 A8KBT8 A8WFS5 A8WFS6 B4F6P1 B8A6G0 E7F0H3 E9QBE2 F1QW40 Q1LYC9 Q1RM69 Q568D6 Q5BLH5 Q6DG44 Q6DHT0 Q6IVB9 Q7SZM5 Q7T2J2 Q7T317 Q7ZUR1 Q803T1 Q90Z37	Capn1 DC E-cad MMPLf ZFMMP-9 bcan capn1 capn1a capn2a capn5a capn7 capn9 capns1 capns1a capns1b cb386 cb536 cb545 cb616 cdh1 ctsk ctsl ctsl.1 dcn decorin fa18a08 fb77d06 fi32a12 fj05a08 fj67g01 im:6910535 mmp14a mmp2 mmp30 mmp9 sb:cb386 si:ch211-202f3.4 si:dkey-239j18.2 si:dkey-269i1.3 si:dkey-46g23.4 spp1 wu:fa18a08 wu:fa95f03 wu:fa99h12 wu:fb02g06 wu:fb07b05 wu:fb08b05 wu:fb72b09 wu:fb77d06 wu:fb81g08 wu:fi32a12 wu:fi98c09 wu:fj05a08 wu:fj67g01 wu:fk89d01 wu:fl09e04 zgc:110367 zgc:110603 zgc:111821 zgc:113590 zgc:136396 zgc:136872 zgc:153446 zgc:162184 zgc:171446 zgc:171735 zgc:63788 zgc:64165 zgc:92089 zgc:92451	Danio rerio (zebrafish)
Glycolysis	ADP-dependent glucokinase ATP-dependent 6-phosphofructokinase Beta-enolase Enolase 4 Fructose-bisphosphate aldolase B Fructose-bisphosphate aldolase C-B Fructose-bisphosphate aldolase Glucosamine-6-phosphate isomerase Glucose 1,6-bisphosphate synthase Glucose-6-phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase 2 Glyceraldehyde-3-phosphate dehydrogenase Hexokinase-1 Hexokinase-2 Phosphoglycerate kinase Phosphoglycerate mutase Phosphoglycerate mutase Phosphoglycerate mutase Pyruvate kinase Pyruvate kinase Triosephosphate isomerase B phosphopyruvate hydratase phosphopyruvate hydratase	A0JML7 B7ZVE8 Q08BC6 Q0IJ39 Q567X3 Q5MJ86 Q5XJ10 Q66HV8 Q6DHM0 Q6GQM9 Q6IQP5 Q6TH14 Q7SXK3 Q7SZR4 Q7T3G4 Q7ZUM3 Q7ZV29 Q7ZVL7 Q7ZVT2 Q803Q7 Q8JH70 Q8JH71 Q90XG0	ENO1 PGI adpgk aldoa aldoaa aldob aldoc aldocb bpgm cb1029 cb79 cb883 eno1 eno1a eno2 eno3 eno4 fc09h05 fi09d05 fi17h06 fj24f12 fj33f03 gapdh gapdh-2 gnpda1 gpi gpib hk1 hk2 im:7140576 im:7148527 pfkm pfkma pgam1 pgam1a pgam2 pgi-2 pgk1 pgm2l1 pklr pkm2 pkm2a pkma sb:cb79 tpi1b wu:fa28b10 wu:fb10b11 wu:fb81h05 wu:fc09d08 wu:fc09h05 wu:fc16e02 wu:fc21e02 wu:fd15e01 wu:fd59b07 wu:fi09d05 wu:fi17h06 wu:fi31b04 wu:fi32b03 wu:fi37e08 wu:fj24f12 wu:fj33f03 wu:fj36g06 wu:fk58e02 wu:fq14b11 zgc:110691 zgc:153956 zgc:198285 zgc:55790 zgc:55926 zgc:56252 zgc:63876 zgc:73152 zgc:77618 zgc:77899 zgc:92230 zgc:92344 zgc:92418	Danio rerio (zebrafish)	G58161NS
Synthesis of PA	1-acyl-sn-glycerol-3-phosphate acyltransferase delta 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma 1-acyl-sn-glycerol-3-phosphate acyltransferase Acid phosphatase 6, lysophosphatidic Alkaline phosphatase Alkaline phosphatase Cytosolic phospholipase A2 Glycerol-3-phosphate acyltransferase 2, mitochondrial Glycerol-3-phosphate acyltransferase 3 Glycerol-3-phosphate acyltransferase 4 Glycerol-3-phosphate dehydrogenase 1-like protein Glycerol-3-phosphate dehydrogenase [NAD(+)] Group XIIA secretory phospholipase A2 precursor Lipase member H Lysocardiolipin acyltransferase 1 Lysophosphatidylcholine acyltransferase 1 Mitochondrial cardiolipin hydrolase Mitoguardin 1 Mitoguardin 2 Phospholipase A2 alkaline phosphatase	A0JMM2 A3KNJ5 A3KNW0 A4QP00 A8WG92 H9GX67 P50392 Q08CV3 Q1LWG4 Q4QRJ9 Q58EF1 Q5BLE2 Q5XIZ6 Q5XJS0 Q6DBU8 Q6DG38 Q6DHQ7 Q6NYV8 Q6PGY2 Q7T1E0 Q7ZWC9	Gpd1 acp6 agpat2 agpat3 agpat4 agpat6 agpat8 agpat9 alp3 alpi alpi.1 alpi.2 aytl2 cpla2 fam73a fam73b fb68b10 fc21c07 fd13g09 fj78c06 gpat2 gpat3 gpat4 gpd1b gpd1h gpd1l im:7147584 im:7149526 im:7149588 lclat1 liph lpcat1 lycat miga1 miga2 pla2g10 pla2g12a pla2g4 pla2g4a pld6 si:ch211-262h13.1 si:ch211-262h13.2 wu:fa16h03 wu:fa95f04 wu:fb68b10 wu:fc21c07 wu:fc25a07 wu:fc58b05 wu:fd13g09 wu:fi89e03 wu:fj78c06 wu:fq33b10 zgc:110409 zgc:110794 zgc:136875 zgc:153984 zgc:162119 zgc:162485 zgc:56524 zgc:63605 zgc:66051 zgc:85742	Danio rerio (zebrafish)
Glycosphingolipid catabolism	Cytosolic beta-glucosidase Neutral ceramidase Non-lysosomal glucosylceramidase Sphingomyelin phosphodiesterase 4 exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase exo-alpha-sialidase sphingomyelin phosphodiesterase sphingomyelin phosphodiesterase	A0JMM3 A7TUD6 B1B5D9 E7F5W0 F1QUD7 Q4V9A4 Q502A1 Q503Z4 Q5W7F1 Q6PFJ7	NSMase asah2 gba2 gba3 im:6912336 im:6912508 nSMase2 neu3.2 neu3.3 neu3.5 neu4 neuc.1 sb:eu489 si:ch73-316n6.2 si:dkey-11j5.6 smpd2 smpd2a smpd3 smpd4 zgc:100806 zgc:109998 zgc:153998	Danio rerio (zebrafish)	G58161NS
Condensation of Prophase Chromosomes	Condensin-2 complex subunit D3 Condensin-2 complex subunit G2 Condensin-2 complex subunit H2 Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2 Histone H2B 3 Histone H2B Histone H2B Histone H2B Histone H4 Histone lysine demethylase PHF8 N-lysine methyltransferase KMT5A-A Retinoblastoma 1 Serine/threonine-protein kinase PLK Structural maintenance of chromosomes protein Uncharacterized protein LOC100126107	A0JMQ4 A3KPR4 A7E2M8 A7MCA8 B3DJF8 B8A5K9 E7FH61 P0CH95 Q071E0 Q0Z946 Q4KMI8 Q5BJA5 Q5RH01 Q5XJK2 Q6PC60 Q71PD7 Q7SZF2 Q7T3L7 Q7ZTT0 Q9IB44 R4GE15	LOC100150038 LOC100329358 LOC100331412 LOC100332229 LOC103908680 LOC108181627 LOC562770 LOC570661 LOC794549 SMC2L1 cb267 cb525 cb636 ccnb ccnb1 cdc2 cdk1 cycb cycb1 fb92e05 h2af1al h2afvb h2afvl h2afx1 h2afza h2av h2ax1 h2az2a h2az2b hist2h2l id:ibd2253 ik:tdsubc_2d1 im:6896397 kmt5aa ncapd3 ncapg2 ncaph2 phf8 plk plk1 rb1 set8a setd8 setd8a si:ch211-113a14.17 si:ch211-113a14.29 si:ch211-113a14.6 si:ch73-36p18.4 si:dkey-108k21.12 si:dkey-108k21.18 si:dkey-108k21.28 si:dkey-23a13.7 smc2 wu:fa19g04 wu:fb16d01 wu:fb16e07 wu:fb37g11 wu:fb76g03 wu:fb92e05 wu:fc30e01 wu:fi21c01 xx:tdsubc_2d1 zeh1628 zgc:112234 zgc:154147 zgc:173585 zgc:173587 zgc:194998 zgc:55326 zgc:55549 zgc:56685 zgc:92032	Danio rerio (zebrafish)
The canonical retinoid cycle in rods (twilight vision)	11-cis retinol dehydrogenase isoform X1 Cellular retinaldehyde-binding protein b Cyp4v2 protein Dehydrogenase/reductase (SDR family) member 9 Lecithin retinol acyltransferase Rdh12 protein Retinoid isomerohydrolase Retinol binding protein 1b, cellular Retinol dehydrogenase 10-A Retinol dehydrogenase 1 Rhodopsin	A0JMQ6 A1L1W4 B0R174 F1Q7T8 F1RCW4 P35359 Q6DG78 Q6P027 Q6PBR3 Q6PBW5 Q7ZUX4	CRALBPb RDHA RDHB cyp4v2 cyp4v2a dhrs9 im:6901729 im:7136890 lrat lrata rbp1 rbp1.1 rbp1b rdh1 rdh10a rdh12 rdh1l rdh5 rho rlbp1 rlbp1b rpe65a rpepa sb:eu611 si:dkey-102c8.5 wu:fb64b07 wu:fd50b03 wu:fj43a10 zfo2 zgc:100825 zgc:154161 zgc:73286 zgc:77766 zgc:92430	Danio rerio (zebrafish)
Ovarian tumor domain proteases	Cellular tumor antigen p53 E2 ubiquitin-conjugating enzyme E3 ubiquitin-protein ligase RNF128 precursor Estrogen receptor Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Rho-related GTP-binding protein RhoA-C TNF receptor-associated factor 6 TNF receptor-associated factor Transitional endoplasmic reticulum ATPase Ubiquitin thioesterase OTU1 Ubiquitin thioesterase zranb1-B Ubiquitin thioesterase ubiquitinyl hydrolase 1	A0JMQ9 P57717 P79734 Q567B1 Q6DEG0 Q6DH16 Q6IWL4 Q6NW80 Q6NX00 Q6PC58 Q7T2E8 Q7ZU99 Q7ZZ56	cdc48 drp53 esr esr1 fa11a08 fb17f04 fb73f10 fc83f12 fd16b10 fk90e11 nr3a1 otub1a otub1l otud3 pten ptenb rhoac rnf128 rnf128a si:bz1g13.4 tp53 traf3 traf6 ube2d1 ube2d1b vcp wu:fa11a08 wu:fb17f04 wu:fb57h05 wu:fb73f10 wu:fc16h06 wu:fc83f12 wu:fd16b10 wu:fk90e11 yod1 zgc:73096 zgc:77843 zgc:85911 zgc:92367 zgc:92685 zranb1 zranb1b	Danio rerio (zebrafish)
Assembly of collagen fibrils and other multimeric structures	Collagen alpha-1(II) chain precursor Collagen alpha-1(XI) chain Collagen alpha-1(XXVII) chain B Collagen alpha-2(I) chain precursor Collagen alpha-3(V) chain precursor Collagen, type I, alpha 1b precursor	A0MSJ1 D6MUD3 D6MUD6 Q2LDA1 Q6IQX2 Q6PEI9	COL11A1b COL5A3a alpha2(I) alpha3(I) col11a1 col11a1b col1a1b col1a2 col1a3 col27a1 col27a1b col2a1 col2a1a col5a3 col5a3a coll2a1 fb38c06 fc10c01 fj59a10 hm:zeh0348 hm:zehn2357 si:dkey-87l9.2 wu:fa95h05 wu:fa98d05 wu:fa99g10 wu:fb04c08 wu:fb11d06 wu:fb38c06 wu:fb54e07 wu:fc10c01 wu:fd02a10 wu:fj59a10 zehn2357	Danio rerio (zebrafish)
Collagen degradation	5-phosphohydroxy-L-lysine phospho-lyase 72 kDa type IV collagenase Cationic trypsin-3 precursor Collagen alpha-1(XXVII) chain B Matrix metalloproteinase-9 Si Stromelysin-2 precursor Trypsinogen 1a Trypsinogen 1b Uncharacterized protein LOC474322 precursor	A0MSJ1 E7FBA9 E7FCZ0 F1R894 Q1RM69 Q2YDQ8 Q561Z7 Q5XIZ0 Q7SZM5 Q7T317	MMPLf ZFMMP-9 col27a1 col27a1b fj05a08 mmp2 mmp30 mmp9 phykpl prss1 prss2a prss59.1 prss59.2 si:ch73-103b2.3 si:dkey-33m11.8 try tryl wu:fa99h12 wu:fb02g06 wu:fb07b05 wu:fb57g08 wu:fb61f11 wu:fd14c02 wu:fi98c09 wu:fj05a08 wu:fk89d01 zgc:109701 zgc:136396 zgc:64165 zgc:66382	Danio rerio (zebrafish)
Lysosphingolipid and LPA receptors	Lysophosphatidic acid receptor 1 Lysophosphatidic acid receptor 1 Lysophosphatidic acid receptor 2 isoform X1 Lysophosphatidic acid receptor 5a Sphingosine 1-phosphate receptor 1 Sphingosine 1-phosphate receptor 2 Sphingosine 1-phosphate receptor 5	A0PJS0 F1QFF1 K9M3I1 Q6DHQ8 Q6PHE1 Q9DDK4 Q9I8K8	Lpar3 edg1 edg2 edg5 lpar1 lpar2a lpar3 lpar5a lpar6 lpar6l p2ry5 s1pr1 s1pr2 s1pr5b si:dz22b13.1 si:dz46m7.1 wu:fb62d01 zgc:101053 zgc:158362 zgc:66034 zgc:92157	Danio rerio (zebrafish)
Regulation of KIT signaling	E3 ubiquitin-protein ligase CBL Growth factor receptor-bound protein 2 Growth factor receptor-bound protein 2a Kit ligand Mast/stem cell growth factor receptor kita Proto-oncogene tyrosine-protein kinase Src Son of sevenless homolog Tyrosine-protein kinase fynb Tyrosine-protein kinase yes Tyrosine-protein kinase	A1A5H8 A2RRV5 F1RDG9 Q1JPZ3 Q1RLY5 Q56JH6 Q5RKN6 Q5U376 Q6PC73 Q8JFR5	cbl fb18e12 fj59e07 fynb grb2 grb2a grb2b kit kita kitla kitlga lck sos1 sparse src wu:fb18e12 wu:fb34e06 wu:fd16a12 wu:fj59e07 yes yes1 zgc:103549 zgc:136695 zgc:158274 zgc:73077 zgc:92560	Danio rerio (zebrafish)
EPHA-mediated growth cone collapse	Proto-oncogene tyrosine-protein kinase Src Rho-related GTP-binding protein RhoA-C Tyrosine-protein kinase fynb Tyrosine-protein kinase yes	A1A5H8 F1RDG9 Q1JPZ3 Q7T2E8	fynb rhoac src yes yes1	Danio rerio (zebrafish)
CS/DS degradation	Biglycan Brevican core protein Decorin Hyaluronidase Iduronate 2-sulfatase precursor Neurocan b Versican core protein	A1A5V0 A4JYN2 F1QEZ8 Q29RC1 Q6GMI5 Q75ZI3 Q803T1	DC bcan bgn bgna cspg2b dcan dcn decorin fb99b07 fi32a12 hyal1 ids ncanb vcanb wu:fb99b07 wu:fi32a12 zgc:158245 zgc:91989	Danio rerio (zebrafish)
HS-GAG degradation	Glypican 2 Glypican 5a Glypican 6a Glypican-1 Glypican-3 Glypican-4 precursor Heparanase Iduronate 2-sulfatase precursor Syndecan 4 Syndecan	A1A5V0 A7MBT1 B3DJ94 F1QCC6 Q0JY12 Q1LVP9 Q66I66 Q6V9Y8 V5NES1 V5NF87	Gpc2 Gpc5a Gpc6a SDC4 cb440 chunp6920 fc47a08 fe05f10 gal3st4 gpc1 gpc2 gpc3 gpc4 gpc4/6 gpc5 gpc5a gpc6 gpc6a gpc6l hpse ids im:6970974 im:7144134 kny knypek sdc2 sdc4 sdc4l si:ch1073-86a3.1 wu:fc47a08 wu:fc47g09 wu:fe05f10 zgc:103676 zgc:158245 zgc:194854	Danio rerio (zebrafish)
VEGFA-VEGFR2 Pathway	Cell division control protein 42 homolog Cytochrome b-245 heavy chain Cytochrome b-245 light chain Cytoplasmic protein Cytoplasmic protein Heat shock protein beta-1 Integrin alpha V Integrin beta MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 12 Mitogen-activated protein kinase 14B Neutrophil cytosol factor 1 Neutrophil cytosol factor 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Proto-oncogene tyrosine-protein kinase Src Ras-related C3 botulinum toxin substrate 1 Rho-associated protein kinase Rho-related GTP-binding protein RhoA-C Tyrosine-protein kinase fynb Vascular endothelial growth factor A-A Vascular endothelial growth factor receptor 2 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase non-specific protein-tyrosine kinase non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A1A5X1 A2VCY2 A4VAK4 B0S6V7 B3DHG9 E7F251 E7F6M0 F1QAD7 F1RDG9 O73682 Q1JPZ3 Q3LTM3 Q3LTM5 Q4V9A1 Q4Z8P3 Q52WY2 Q5GIT4 Q5RHW0 Q6DBV8 Q6DG42 Q6IQ84 Q6PH62 Q7T2A7 Q7T2E8 Q7T2F2 Q7T2P8 Q7T374 Q7ZSZ9 Q90Y37 Q9DGE1	CH1073-57O22.1 Prkacb cb153 cb422 cb660 cb893 cdc42 cdc42a cyba cybb fd20h08 fj62g06 flk1b fynb hsp1 hsp25 hsp27 hspb1 id:ibd2821 im:6900512 im:7147817 itgav itgb3.1 itgb3b kdr kdrb kinase mapk11 mapk12b mapk14 mapk14b mapkapk2 mapkapk2a mapkapk3 ncf1 ncf2 nck1b nck2b pak2 pak2a pik3ca pik3cb pik3r1 pik3r2 prkacab prkacba ptk2b ptk2bb ptk2bl pyk2 rac1 rac1a rhoac rock2 rock2a rok2 sb:cb660 si:ch211-147g19.3 si:dkey-14d8.5 si:dz198m22.1 src vegf vegfa vegfaa wu:fb07d08 wu:fb30e10 wu:fb65b05 wu:fb71h01 wu:fc56c10 wu:fd16e02 wu:fd20h08 wu:fi03a01 wu:fj62g06 zgc:103437 zgc:136222 zgc:158342 zgc:158405 zgc:55823 zgc:55917 zgc:63918 zgc:64054 zgc:64144 zgc:66077 zgc:86905 zgc:86934 zgc:91798 zgc:91856 zgc:92024	Danio rerio (zebrafish)
Oxidative Stress Induced Senescence	Cellular tumor antigen p53 Chromobox homolog 7a Chromobox homolog 8b Chromobox protein homolog 2 Dual specificity mitogen-activated protein kinase kinase 6 E3 ubiquitin-protein ligase Mdm2 E3 ubiquitin-protein ligase RING2 Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2 Histone H2B 3 Histone H2B Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Histone-binding protein RBBP4 Histone-binding protein RBBP7 Histone-lysine N-methyltransferase EZH2 MAP kinase-activated protein kinase 2 MAP kinase-activated protein kinase 3 MAP kinase-activated protein kinase 5 Mitogen-activated protein kinase 11 Mitogen-activated protein kinase 14B Mitogen-activated protein kinase 8 Mitogen-activated protein kinase Mitogen-activated protein kinase Polycomb complex protein BMI-1-A Polycomb protein eed Polycomb protein suz12-B Polyhomeotic-like protein 2 Protein Mdm4 Protein c-Fos Transcription factor Jun Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein LOC100126107 mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase	A1A5X1 A3KPR4 A7E2M8 A7MCA8 B0R1D5 B1NA68 B3DJF8 D6RRB7 O42354 P79734 Q08BS4 Q0Z946 Q3B7P7 Q4QRF4 Q502N4 Q566T0 Q568R0 Q5BJA5 Q5XJK2 Q6DHN7 Q6IQ84 Q6NZT5 Q6P0S4 Q6P3H7 Q6PC60 Q6PI20 Q71PD7 Q7SXA3 Q7T2F2 Q7ZTT0 Q7ZTY4 Q7ZUW7 Q7ZVK8 Q7ZW72 Q803I4 Q8JIQ9 Q8JIR0 Q8QHL5 Q9DGD9 Q9DGE0 Q9DGE1 R4GE15	ERK1 LOC100150038 LOC100329358 LOC100331412 LOC100332229 LOC103908680 LOC108181627 LOC562770 LOC570661 LOC794549 MKK4 MKK4A-l MKK7 bmi1 bmi1a c-Jun cb1065 cbx2 cbx7a cbx8b drp53 edr2 eed ezh2 fi06b09 fj36h07 fos fosab h2af1al h2afvb h2afvl h2afx1 h2afza h2av h2ax1 h2az2a h2az2b h3-5 h3f3a h3f3b.1 h3f3c h3f3d hist2h2l hm:zeh0386 ik:tdsubc_1f2 im:6896397 im:7138386 jnk1 jun map2k3 map2k4 map2k4A map2k4a map2k6 map2k7 mapk1 mapk11 mapk14 mapk14b mapk3 mapk8 mapkapk2 mapkapk2a mapkapk3 mapkapk5 mdm2 mdm4 mdmx pc1 pcgf4a ph2 phc2 psc1 rbb4 rbb4l rbbp4 rbbp7 ring1b rnf2 rps27a si:ch211-113a14.17 si:ch211-113a14.29 si:ch211-113a14.6 si:ch211-254d18.2 si:ch73-36p18.4 si:dkey-108k21.12 si:dkey-108k21.18 si:dkey-108k21.28 si:dkey-23a13.7 suz12 suz12b tdsubc_1f2 tp53 uba52 wu:fa91f08 wu:fb30e10 wu:fc56c10 wu:fd20e09 wu:fi03a01 wu:fi06b09 wu:fj36h07 xx:tdsubc_1f2 zERK1 zERK2 zgc:103563 zgc:110152 zgc:111978 zgc:112234 zgc:113984 zgc:123344 zgc:136500 zgc:152758 zgc:158342 zgc:173585 zgc:173587 zgc:194998 zgc:56685 zgc:65863 zgc:66168 zgc:77885 zgc:86905 zgc:92197	Danio rerio (zebrafish)
WNT ligand biogenesis and trafficking	Protein Wnt-10a Protein Wnt-10b Protein Wnt-1 Protein Wnt-2 Protein Wnt-4a Protein Wnt-5b Protein Wnt-8a Protein Wnt-8b Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Protein Wnt Transmembrane emp24 domain-containing protein 5	A1BPR0 B0LK22 B6V3E1 B6V3E2 P24257 P43446 P47793 P51028 P51029 Q1L130 Q4JLT0 Q6IYD9 Q7T2E9 Q801F7 Q92048 Q92050	Zwnt[a] cgi100 cgi1000 int-1 tmed5 wnt-1 wnt-10a wnt-2 wnt-4 wnt-5 wnt-8 wnt-8b wnt1 wnt10a wnt10b wnt2 wnt2bb wnt3 wnt3 l wnt3a wnt3l wnt4 wnt4a wnt5 wnt5a wnt5b wnt7a wnt7aa wnt8 wnt8a wnt8b wnt9a wnt9b wnt[a] zgc:153617 zgc:63936	Danio rerio (zebrafish)
Adherens junctions interactions	Cadherin 11, osteoblast Cadherin 6 Cadherin-17 Cadherin-1 Cadherin-2 Cadherin-4 Cadherin-5 Cadherin-6 Cell adhesion molecule 1b isoform 1 Nectin 1b Nectin-3-like protein RNase 2 RNase 3 Ribonuclease-like 3	A1L1M6 A5HAK0 A5HAK1 A5HAK2 B0F6R1 B0JYH6 B3DGG4 Q2MLR9 Q58EG3 Q5WN09 Q68SP4 Q90275 Q90X63 Q90Z37	E-cad R-cadherin cadm1b cb903 cdh1 cdh10 cdh10a cdh11 cdh17 cdh2 cdh4 cdh5 cdh6 cdhvn fb65d02 nectin1b nectin3 pac pvrl1b pvrl3l rcad rnasel2 rnasel3 rnasel4 sc:d0664 si:ch211-139g14.6 vnc wu:fb65d02 zgc:103673 zgc:136316	Danio rerio (zebrafish)

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