GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **876 - 900** of **1070** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism
NoRC negatively regulates rRNA expression	Histone H2A type 2-A Histone H2A.J Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2B type 1-A Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H3.1 Histone H3.3 Histone H3 Histone H4 Methyl-CpG binding domain protein 2	A0A0G2JXI9 A0A8I5ZSA8 A0A8I5ZYY0 A0A8I6A2W1 A0A8I6A7P3 A0A8I6AFW8 A0A8I6AWT3 A0A8I6G659 A9UMV8 D3ZJ08 D3ZVK7 D3ZXP3 D4A986 D4ACM0 G3V9C7 M0RBQ5 P0CC09 P62804 P84245 Q00729 Q6LED0	ENSRNOG00000062927 ENSRNOG00000064540 ENSRNOG00000066901 ENSRNOG00000068034 H2ab3 H2ac10 H2ac18 H2ac4 H2afb3 H2afx H2aj H2ax H2az2 H2bc1 H2bc12l1 H2bc6 H2bcl1 H2bcl2 H2bu1 H3-3b H3.3b H3c13 H3f3b H4c16 H4c2 H4f16 H4ft Hist1h2ba Hist1h2bc Hist1h2bg Hist1h2bo Hist1h2bq Hist1h4b Hist1h4m Hist2h2aa3 Hist2h3c2 Hist4 Hist4h4 LOC100365043 LOC100910200 LOC120097726 LOC684797 Mbd2 Th2b	Rattus norvegicus (Norway rat)
SIRT1 negatively regulates rRNA expression	Histone H2A type 2-A Histone H2A.J Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2A Histone H2B type 1-A Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H2B Histone H3.1 Histone H3.3 Histone H3 Histone H4 Histone-lysine N-methyltransferase NAD-dependent protein deacetylase sirtuin-1 Ribosomal RNA-processing protein 8	A0A0G2JXI9 A0A0G2JZ79 A0A8I5ZSA8 A0A8I5ZYY0 A0A8I6A2W1 A0A8I6A3A4 A0A8I6A7P3 A0A8I6AFW8 A0A8I6AWT3 A0A8I6G659 A9UMV8 D3ZJ08 D3ZVK7 D3ZXP3 D4ACM0 G3V9C7 M0RBQ5 P0CC09 P62804 P84245 Q00729 Q5U4F0 Q6LED0	ENSRNOG00000062927 ENSRNOG00000064540 ENSRNOG00000066901 ENSRNOG00000068034 H2ab3 H2ac10 H2ac18 H2ac4 H2afb3 H2afx H2aj H2ax H2az2 H2bc1 H2bc12l1 H2bc6 H2bcl1 H2bcl2 H2bu1 H3-3b H3.3b H3c13 H3f3b H4c16 H4c2 H4f16 H4ft Hist1h2ba Hist1h2bc Hist1h2bg Hist1h2bo Hist1h2bq Hist1h4b Hist1h4m Hist2h2aa3 Hist2h3c2 Hist4 Hist4h4 LOC100365043 LOC100910200 LOC120097726 LOC684797 Rrp8 Sirt1 Suv39h1 Th2b	Rattus norvegicus (Norway rat)
PRPP biosynthesis	Ribose-phosphate pyrophosphokinase 1 Ribose-phosphate pyrophosphokinase 1 Ribose-phosphate pyrophosphokinase 2 Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein ribose-phosphate diphosphokinase	A0A0G2JSV3 A0A8I6AC83 M0RBK1 P09330 P60892	ENSRNOG00000063771 LOC314140 Prps1 Prps1l1 Prps1l3 Prps2	Rattus norvegicus (Norway rat)
Regulation of IFNA/IFNB signaling	Interferon 1ai1 Interferon 1ai2 Interferon 1ai3 Interferon alpha and beta receptor subunit 1 Interferon alpha and beta receptor subunit 2 Interferon alpha-1-like Interferon alpha-12-like Interferon alpha-12-like Interferon alpha-12-like Interferon alpha-12-like Interferon alpha-12-like Interferon alpha-1 Interferon beta Signal transducer and activator of transcription 4 Signal transducer and activator of transcription Tyrosine-protein kinase Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 11 Tyrosine-protein phosphatase non-receptor type 1 Tyrosine-protein phosphatase non-receptor type 6 Uncharacterized protein ubiquitinyl hydrolase 1	A0A0G2JX93 A0A7R8C3L7 A0A8I5ZN08 A0A8I5ZQR5 A0A8I6A4N8 A0A8I6AEQ7 A0A8I6AM23 A0A8I6AN84 A0A8I6ANZ6 A0A8I6GMD9 D3Z919 D3ZD03 D3ZDS9 D3ZFH0 F7EYG9 M0R8H7 P05011 P20417 P41499 P70499 P81718 Q6AYC7	ENSRNOG00000065554 If1ai1 If1ai2 If1ai3 Ifna1 Ifna12l Ifna4 Ifna4l1 Ifnar1 Ifnar2 Ifnb Ifnb1 Jak1 LOC100911527 LOC120103158 LOC120103159 LOC120103160 LOC120103161 LOC120103162 LOC120103163 LOC120103164 Ptph6 Ptpn1 Ptpn11 Ptpn6 RGD1560539 Stat1 Stat2 Stat4 Tyk2 Usp18	Rattus norvegicus (Norway rat)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Dual specificity mitogen-activated protein kinase kinase 7 Interleukin-1 receptor-associated kinase-like 2 Mitogen-activated protein kinase 10 Mitogen-activated protein kinase 8 Mitogen-activated protein kinase 9 Mitogen-activated protein kinase kinase kinase 7 NF-kappa-B essential modulator NF-kappa-B essential modulator Nucleotide-binding oligomerization domain containing 1 Nucleotide-binding oligomerization domain containing 2 Receptor-interacting serine/threonine-protein kinase 2 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 TGF-beta activated kinase 1/MAP3K7 binding protein 1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TNF receptor-associated factor 6 Ubiquitin-conjugating enzyme E2 variant 1 mitogen-activated protein kinase kinase non-specific serine/threonine protein kinase	A0A0G2JYX9 A0A0G2K4Z7 A0A0U1RRU5 A0A8I6A3Q1 A0A8I6ABN5 A0A8I6AH74 B5DF45 D4ADT7 G3V783 P0C8E4 P49185 P49186 P49187 Q4KSH7 Q4QQS0 Q5U303 Q6TMG5 S4VP54	ENSRNOG00000067007 Ikbkg Irak1 Irak2 Jnk1 Jnk2 Jnk3 Map2k4 Map2k7 Map3k7 Map3k7ip2 Mapk10 Mapk8 Mapk9 Nemo Nod1 Nod2 Prkm10 Prkm8 Prkm9 Ripk2 Tab1 Tab2 Tab3 Traf6	Rattus norvegicus (Norway rat)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6 Toll/interleukin-1 receptor domain-containing adapter protein	B5DF45 D3ZXA5 Q5XIC2 Q62925	Ecsit Map3k1 Mekk Mekk1 Tirap Traf6	Rattus norvegicus (Norway rat)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	B5DF45 Q5XIC2 Q62925	Ecsit Map3k1 Mekk Mekk1 Traf6	Rattus norvegicus (Norway rat)
MyD88 cascade initiated on plasma membrane	Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial Mitogen-activated protein kinase kinase kinase 1 TNF receptor-associated factor 6	B5DF45 Q5XIC2 Q62925	Ecsit Map3k1 Mekk Mekk1 Traf6	Rattus norvegicus (Norway rat)
Lysosphingolipid and LPA receptors	Lysophosphatidic acid receptor 1 Lysophosphatidic acid receptor 2 Lysophosphatidic acid receptor 3 Lysophosphatidic acid receptor 5 Phospholipid phosphatase related 5 Phospholipid phosphatase-related protein type 1 Phospholipid phosphatase-related protein type 2 Phospholipid phosphatase-related protein type 3 Phospholipid phosphatase-related protein type 4 Sphingosine 1-phosphate receptor 1 Sphingosine 1-phosphate receptor 2 Sphingosine 1-phosphate receptor 5 Sphingosine-1-phosphate receptor 3 Sphingosine-1-phosphate receptor 4	A0A0G2K505 A0A8I5ZVX2 D4ADR1 D4AEH8 F1M9D3 P47752 P48303 P61794 Q6W5G4 Q6WAY2 Q7TMB0 Q7TMB7 Q8K5E0 Q9JKM5	Edg1 Edg2 Edg5 Edg7 Edg8 Gpcr91 Lpa1 Lpa3 Lpar1 Lpar2 Lpar3 Lpar5 Lppr1 Lppr2 Lppr3 Lppr4 Nrg1 Php1 Plppr1 Plppr2 Plppr3 Plppr4 Plppr5 Prg1 Prg2 Prg3 Prg4 S1pr1 S1pr2 S1pr3 S1pr4 S1pr5	Rattus norvegicus (Norway rat)
Toll Like Receptor 9 (TLR9) Cascade	Early endosome antigen 1 Phosphatidylinositol 3-kinase catalytic subunit type 3 Phosphoinositide 3-kinase regulatory subunit 4 Rabenosyn, RAB effector Toll-like receptor 9	A0A8I6AIN6 D3ZL11 M0RAA8 O88763 P0C0R5	Eea1 Pik3c3 Pik3r4 Rbsn Tlr9 Vps34 Zfyve20	Rattus norvegicus (Norway rat)
Eukaryotic Translation Elongation	Elongation factor 1-alpha 1 Elongation factor 1-delta Elongation factor 1-gamma Eukaryotic translation elongation factor 1 beta 2	A0A8I6AEG7 P62630 Q68FR6 Q68FR9	Eef1a Eef1a1 Eef1b2 Eef1d Eef1g	Rattus norvegicus (Norway rat)
HSF1 activation	14-3-3 protein epsilon Elongation factor 1-alpha 1 Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Heat shock transcription factor 1 Prostaglandin E synthase 3 Transitional endoplasmic reticulum ATPase	F1MAF1 P34058 P46462 P62260 P62630 P82995 P83868	Eef1a Eef1a1 Hsf1 Hsp84 Hsp86 Hsp90aa1 Hsp90ab1 Hspc3 Hspca Hspcb Ptges3 Tebp Vcp Ywhae	Rattus norvegicus (Norway rat)
Peptide chain elongation	Elongation factor 2	P05197	Eef2	Rattus norvegicus (Norway rat)
EPH-Ephrin signaling	EPH receptor A10 Ephrin A2 Ephrin A3 Ephrin A4 Ephrin B3 Ephrin type-A receptor 3 Ephrin type-A receptor 5 Ephrin type-A receptor 6 Ephrin type-A receptor 7 Ephrin type-B receptor 1 Ephrin type-B receptor 3 Ephrin type-B receptor 6 Ephrin-A1 Ephrin-A5 Ephrin-B1 receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A0G2JV56 D3ZBN3 D3ZDH4 D3ZEN1 D3ZH39 D3ZZK3 F1LX55 F1MA19 F1MAJ0 G3V7D4 M0RDA4 O08680 P09759 P0C0K7 P52796 P54757 P54758 P54759 P97553 P97605	Efna1 Efna2 Efna3 Efna4 Efna5 Efnb1 Efnb3 Ehk-1 Ehk-2 Ehk-3 Ehk2 Ehk3 Ekh1 Elk Epgl1 Epha1 Epha10 Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Eplg2 Eplg7 Epth2 LOC686310 Lerk1 Lerk2 Lerk7 Rek4 Rek7 Tyro4	Rattus norvegicus (Norway rat)
MET activates PTK2 signaling	Focal adhesion kinase 1 Hepatocyte growth factor receptor Hepatocyte growth factor Integrin alpha 3 variant B Integrin beta-1 Integrin subunit alpha 2 Laminin subunit alpha 4 Multiple epidermal growth factor-like domains protein 6 Proto-oncogene tyrosine-protein kinase Src	A0A0G2K470 F1LTF8 I4DUB5 O35346 O88281 P17945 P49134 P97523 Q9WUD9	Egfl3 Fak Fak1 Hgf ITGA3B Itga2 Itga3 Itgb1 Lama4 Megf6 Met Ptk2 Src	Rattus norvegicus (Norway rat)
Laminin interactions	Integrin alpha 3 variant B Integrin alpha-7 Integrin beta-1 Integrin beta-4 Integrin subunit alpha 6 Laminin subunit alpha 4 Multiple epidermal growth factor-like domains protein 6 Nidogen-2	A0A8I6AJE9 B5DFC9 F1LTF8 I4DUB5 O88281 P49134 Q63258 Q64632	Egfl3 ITGA3B Itga3 Itga6 Itga7 Itgb1 Itgb4 Lama4 Megf6 Nid2	Rattus norvegicus (Norway rat)
PERK regulates gene expression	Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit 2 Eukaryotic translation initiation factor 2 subunit 3, X-linked Eukaryotic translation initiation factor 2-alpha kinase 3	A0A8I6G5P0 P68101 P81795 Q9Z1Z1	Eif2a Eif2ak3 Eif2g Eif2s1 Eif2s2 Eif2s3 Eif2s3x Pek Perk	Rattus norvegicus (Norway rat)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Eukaryotic initiation factor 4A-I Eukaryotic initiation factor 4A-II Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4E-binding protein 1 Eukaryotic translation initiation factor 4E	F7F7A6 M0RD03 P63074 Q5RKI1 Q62622	Eif4a1 Eif4a2 Eif4e Eif4ebp1 Eif4g1	Rattus norvegicus (Norway rat)
Glycerophospholipid catabolism	Glycerophosphocholine cholinephosphodiesterase ENPP6 Glycerophosphodiester phosphodiesterase 1 Patatin-like phospholipase domain containing 6	B0BND0 M0R715 Q9JL55	Enpp6 Gde1 Mir16 Pnpla6	Rattus norvegicus (Norway rat)
Cellular response to hypoxia	Endothelial PAS domain-containing protein 1 Hypoxia inducible factor 1 subunit alpha inhibitor Hypoxia-inducible factor 1-alpha	F7F9I0 O35800 Q9JHS1	Epas1 Hif1a Hif1an Hif2a	Rattus norvegicus (Norway rat)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	Erythropoietin receptor Erythropoietin GRB2-associated binding protein 1 Insulin receptor substrate 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform Phosphoinositide 3-kinase regulatory subunit 5 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0G2K344 A0A8I5Y949 D3ZAL7 D3ZFJ0 D4A4I3 F1MAL5 P29676 Q07014 Q07303 Q62689 Q63787 Q9Z1L0	Epo Epor Gab1 Irs2 Jak2 Lyn Pik3ca Pik3cb Pik3cd Pik3cg Pik3r1 Pik3r5	Rattus norvegicus (Norway rat)
Signaling by Erythropoietin	Erythropoietin receptor Insulin receptor substrate 2 Tyrosine-protein kinase JAK2 Tyrosine-protein kinase Lyn	F1MAL5 Q07014 Q07303 Q62689	Epor Irs2 Jak2 Lyn	Rattus norvegicus (Norway rat)
GRB7 events in ERBB2 signaling	Growth factor receptor-bound protein 7 Pro-neuregulin-1, membrane-bound isoform Pro-neuregulin-2, membrane-bound isoform Receptor tyrosine-protein kinase erbB-2 Receptor tyrosine-protein kinase erbB-3	O35569 P06494 P43322 Q62799 Q9QZC5	Erbb2 Erbb3 Grb7 Ndf Neu Nrg1 Nrg2 Ntak	Rattus norvegicus (Norway rat)
ESR-mediated signaling	Estrogen receptor beta Estrogen receptor Heat shock protein HSP 90-alpha Heat shock protein HSP 90-beta Peptidyl-prolyl cis-trans isomerase FKBP4 Prostaglandin E synthase 3 Serine/threonine-protein phosphatase 5 peptidylprolyl isomerase	F7EYK0 P06211 P34058 P53042 P82995 P83868 Q62986 Q9QVC8	Erbeta Esr Esr1 Esr2 Estr Fkbp4 Fkbp5 Fkbp52 Hsp84 Hsp86 Hsp90aa1 Hsp90ab1 Hspc3 Hspca Hspcb Nr3a1 Nr3a2 Ppp5c Ptges3 Tebp	Rattus norvegicus (Norway rat)
Signaling by NODAL	Forkhead box O3 Mitogen-activated protein kinase 1 Mitogen-activated protein kinase 3 Mothers against decapentaplegic homolog 2 Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog 4	D3ZBQ1 O70436 O70437 P21708 P63086 P84025	Erk1 Erk2 Foxo3 Madh2 Madh3 Madh4 Mapk Mapk1 Mapk3 Prkm1 Prkm3 Smad2 Smad3 Smad4	Rattus norvegicus (Norway rat)

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