GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **499** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Formation of the cornified envelope	Armadillo repeat-containing protein wrm-1 Beta-catenin-like protein hmp-2 Beta-catenin/armadillo-related protein 1 Cadherin-4 Cell junction protein VAB-9 Juxtamembrane domain-associated catenin	G5ED30 O44326 Q10953 Q18825 Q19319 Q9U308	bar-1 cdh-4 hmp-2 jac-1 pvl-1 spy-1 vab-9 wrm-1	Caenorhabditis elegans
Signaling by ERBB2	EGF-like domain-containing protein EGF-like domain-containing protein Heat shock protein 90 Probable Hsp90 co-chaperone cdc37 Receptor tyrosine-protein kinase let-23 Tyrosine protein-kinase src-1	G5EE56 G5EFK8 O02108 O44191 P24348 Q18688	CELE_F14B4.1 cdc-37 daf-21 kin-7 let-23 rme-2 src-1	Caenorhabditis elegans
eNOS activation	EF-hand domain-containing protein Globin family profile domain-containing protein Heat shock protein 90 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2	O17824 Q17941 Q18136 Q18688 Q9XTG7	akt-1 akt-2 cal-5 daf-21 glb-14	Caenorhabditis elegans
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor AcetylCholine Receptor Acetylcholine receptor (51.1 kD) (Acr-22) Acetylcholine receptor subunit alpha-type acr-5 Acetylcholine receptor subunit alpha-type deg-3 Acetylcholine receptor subunit alpha-type des-2 Acetylcholine receptor subunit alpha-type unc-38 Acetylcholine receptor subunit alpha-type unc-63 Acetylcholine receptor subunit beta-type acr-2 Acetylcholine receptor subunit beta-type acr-3 Acetylcholine receptor subunit beta-type lev-1 Acetylcholine receptor subunit beta-type unc-29 Betaine receptor acr-23 Ligand-Gated ion Channel Ligand-Gated ion Channel Ligand-Gated ion Channel Ligand-gated ion channel 4 Neur_chan_LBD domain-containing protein Neur_chan_memb domain-containing protein Neurotransmitter-gated ion-channel ligand binding domain protein Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Proton-gated ion channel subunit pbo-6	A0A3P6P985 B1Q281 G5EDF1 G5EE87 G5EG88 G5EGR1 H2KML8 O18228 O44452 O61216 O61519 O61520 O76554 P48181 P48182 P54244 P54245 P54246 Q19351 Q23022 Q23355 Q27218 Q65XS8 Q6BEQ0 Q93149 Q93329 Q95Y94 Q9N4M3 Q9N587 V6CJ96	acr-12 acr-2 acr-20 acr-21 acr-22 acr-23 acr-24 acr-25 acr-3 acr-4 acr-5 acr-6 acr-8 deg-3 des-2 lev-1 lev-7 lev-8 lgc-10 lgc-11 lgc-12 lgc-3 lgc-30 lgc-31 lgc-4 lgc-5 lgc-6 lgc-7 lgc-8 lgc-9 pbo-6 unc-29 unc-38 unc-63	Caenorhabditis elegans
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	FERM domain-containing protein Moesin/ezrin/radixin homolog 1 PIPK domain-containing protein Sema domain-containing protein Sema domain-containing protein Semaphorin-1A Semaphorin-2A Tyrosine protein-kinase src-1	G5EE56 G5EGK1 O01759 O17905 Q17330 Q95XP4 Q9TYS4 U4PRY7	frm-3 mab-20 plx-1 ppk-1 sema-1a smp-1 smp-2 src-1 tln-1	Caenorhabditis elegans
Aflatoxin activation and detoxification	3-ketosteroid oxygenase CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family CYtochrome P450 family Gamma-glutamyltransferase Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 N-acyl-aliphatic-L-amino acid amidohydrolase Probable cytochrome P450 CYP36A1 Probable cytochrome P450 cyp-35D1	A0A0M7RF98 A0A486WVP7 B5BM47 G5ECD0 G5EE22 H2KY69 H2KYS3 H2L030 H2L0B7 O02627 O02628 O02641 O16220 O16362 O16482 O16670 O16671 O16673 O18256 O44649 O44650 O44651 O44652 O44655 O44656 O44657 O44658 O44704 O44706 O45364 O45659 O61204 O61935 O62377 O62378 P90771 Q20315 Q27465 Q27470 Q27471 Q27482 Q27499 Q5WRS4 Q965T7 Q9N4Q4 Q9N5I1 Q9N5V4	C06A6.4 C53D5.5 CELE_H14N18.4 CELE_T03D8.6 CELE_T19H12.6 CELE_Y7A9A.1 CELE_Y97E10AR.2 cyp-23A1 cyp-23a1 cyp-33A1 cyp-33B1 cyp-33C1 cyp-33C11 cyp-33C12 cyp-33C2 cyp-33C3 cyp-33C4 cyp-33C5 cyp-33C6 cyp-33C7 cyp-33C8 cyp-33C9 cyp-33D1 cyp-33D3 cyp-33E1 cyp-33E2 cyp-33E3 cyp-33a1 cyp-33b1 cyp-33c1 cyp-33c11 cyp-33c12 cyp-33c2 cyp-33c3 cyp-33c4 cyp-33c5 cyp-33c6 cyp-33c7 cyp-33c8 cyp-33c9 cyp-33d1 cyp-33d3 cyp-33e1 cyp-33e2 cyp-33e3 cyp-34A1 cyp-34A10 cyp-34A2 cyp-34A5 cyp-34A6 cyp-34A7 cyp-34A8 cyp-34A9 cyp-34a1 cyp-34a10 cyp-34a2 cyp-34a4 cyp-34a5 cyp-34a6 cyp-34a7 cyp-34a8 cyp-34a9 cyp-35A1 cyp-35A2 cyp-35A3 cyp-35A4 cyp-35A5 cyp-35B1 cyp-35B2 cyp-35B3 cyp-35C1 cyp-35a1 cyp-35a2 cyp-35a3 cyp-35a4 cyp-35a5 cyp-35b1 cyp-35b2 cyp-35b3 cyp-35c1 cyp-35d1 cyp-36A1 cyp36a1 dach-1 daf-9	Caenorhabditis elegans
RNA Polymerase II Pre-transcription Events	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cell division cycle protein 73 Cyclin-T1.1 Cyclin-T1.2 Cyclin-dependent kinase 7 Cyclin-like domain-containing protein DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Ell-associated factor Eaf Elongin-C FACT complex subunit SSRP1-A FACT complex subunit spt-16 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 HTH TFE/IIEalpha-type domain-containing protein IWS1-like protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 OCEL domain-containing protein PHD-type domain-containing protein Prion-like-(Q/N-rich)-domain-bearing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable cyclin-dependent kinase 9 Putative transcription elongation factor S-II RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II transcription factor SIII p18 subunit RNA polymerase II-associated factor 1 homolog RNA polymerase Rpb4/RPC9 core domain-containing protein RNA polymerase-associated protein CTR9 RNA polymerase-associated protein LEO1 RNA-binding protein FUS Suppressor of Ty 6 homolog TAFII28-like protein domain-containing protein TAFII55 protein conserved region domain-containing protein TAFII55 protein conserved region domain-containing protein TATA-box-binding protein Transcription elongation factor B polypeptide 3 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 9 WD_REPEATS_REGION domain-containing protein	A5Z2V7 E9P861 G5ECR7 G5EF68 G5EFV5 G5EG47 G5EG49 G5EGM3 K8F7X5 O01763 O02092 O16991 O17245 O17869 O44499 O44625 O45784 O61707 P16356 P32085 P34424 P34425 P34567 P34703 P41848 P52652 P90783 Q03560 Q09413 Q09645 Q10578 Q17431 Q17558 Q17684 Q17957 Q18265 Q19375 Q19826 Q20361 Q20788 Q21338 Q8MYM8 Q93338 Q93594 Q95PZ4 Q95QG8 Q95ZS0 Q965S0 Q9BKS1 Q9GR61 Q9GZI6 Q9N390 Q9N3C9 Q9N3L2 Q9N554 Q9N5K2 Q9N5R9 Q9N5U5 Q9NEW8 Q9NEX2 Q9TVL3 Q9TXQ9 Q9TYN3 Q9TZ93 Q9U226 Q9U3I0 Q9XVH6	3L686 CELE_F02E9.10 F13B12.1 T24H10.1 TFIIE-alpha TFIIE-beta ama-1 cbp-20 cbp-80 ccnk-1 cdc-73 cdk-7 cdk-9 cit-1.1 cit-1.2 ctr-9 eaf-1 elb-1 elc-1 ell-1 emb-5 fcp-1 fust-1 gtf-2A2 gtf-2E1 gtf-2E2 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2e1 gtf-2e2 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 hmg-4 leo-1 mnat-1 ncbp-1 ncbp-2 pafo-1 pqn-51 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 spt-16 spt-4 spt-5 taf-1 taf-10 taf-11 taf-11.3 taf-12 taf-13 taf-2 taf-3 taf-4 taf-5 taf-6.1 taf-7.1 taf-7.2 taf-9 tbp tbp-1 tceb-3 tpr-3 ttb-1 xpb-1 xpd-1	Caenorhabditis elegans
Regulation of KIT signaling	Discoidin domain-containing receptor tyrosine kinase B E3 ubiquitin-protein ligase CBL Protein kinase C-like 2 Protein kinase domain-containing protein Protein kinase domain-containing protein Sex muscle abnormal protein 5 Son of sevenless homolog	A0A1I6CMA1 P29355 P90980 Q19019 Q21046 Q95ZV7 Q9N5D3	CELE_F59F5.3 ddr-2 kin-11 kin-36 let-341 pkc-2 sem-5 sli-1 sos-1 svh-4	Caenorhabditis elegans
Zinc influx into cells by the SLC39 gene family	Zinc transporter ZIP3 Zinc transporter ZIP8 Zinc transporter zipt-7.2 Zrt (ZRT), Irt- (IRT-) like Protein Transporter Zrt (ZRT), Irt- (IRT-) like Protein Transporter	O62192 P91348 Q22395 Q9XTQ7 U4PS08	hke-4.2 tag-140 zipt-1 zipt-15 zipt-16 zipt-2.4 zipt-7.2	Caenorhabditis elegans
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	60S ribosomal protein L29 Eukaryotic peptide chain release factor GTP-binding subunit Eukaryotic peptide chain release factor subunit 1 Large ribosomal subunit protein P1 Large ribosomal subunit protein P2 Large ribosomal subunit protein eL13 Large ribosomal subunit protein eL14 Large ribosomal subunit protein eL15 Large ribosomal subunit protein eL18 Large ribosomal subunit protein eL19 Large ribosomal subunit protein eL20 Large ribosomal subunit protein eL21 Large ribosomal subunit protein eL22 Large ribosomal subunit protein eL24 Large ribosomal subunit protein eL27 Large ribosomal subunit protein eL28 Large ribosomal subunit protein eL30 Large ribosomal subunit protein eL31 Large ribosomal subunit protein eL32 Large ribosomal subunit protein eL33 Large ribosomal subunit protein eL36 Large ribosomal subunit protein eL38 Large ribosomal subunit protein eL39 Large ribosomal subunit protein eL42 Large ribosomal subunit protein eL43 Large ribosomal subunit protein eL6 Large ribosomal subunit protein eL8 Large ribosomal subunit protein uL10 Large ribosomal subunit protein uL11 Large ribosomal subunit protein uL13 Large ribosomal subunit protein uL14 Large ribosomal subunit protein uL15 Large ribosomal subunit protein uL16 Large ribosomal subunit protein uL18 Large ribosomal subunit protein uL1 Large ribosomal subunit protein uL22 Large ribosomal subunit protein uL23B Large ribosomal subunit protein uL24 Large ribosomal subunit protein uL29 Large ribosomal subunit protein uL2 Large ribosomal subunit protein uL30 Large ribosomal subunit protein uL3 Large ribosomal subunit protein uL4 Large ribosomal subunit protein uL5B Large ribosomal subunit protein uL6 MIF4G domain-containing protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Plectin/S10 N-terminal domain-containing protein Polyadenylate-binding protein Regulator of nonsense transcripts 1 Ribosomal Protein, Small subunit Ribosomal protein L37 Small ribosomal subunit protein eS12 Small ribosomal subunit protein eS17 Small ribosomal subunit protein eS19 Small ribosomal subunit protein eS1 Small ribosomal subunit protein eS21 Small ribosomal subunit protein eS24 Small ribosomal subunit protein eS25 Small ribosomal subunit protein eS26 Small ribosomal subunit protein eS27 Small ribosomal subunit protein eS28 Small ribosomal subunit protein eS4 Small ribosomal subunit protein eS6 Small ribosomal subunit protein eS7 Small ribosomal subunit protein eS8 Small ribosomal subunit protein uS10 Small ribosomal subunit protein uS11 Small ribosomal subunit protein uS12 Small ribosomal subunit protein uS13 Small ribosomal subunit protein uS14 Small ribosomal subunit protein uS15 Small ribosomal subunit protein uS17 Small ribosomal subunit protein uS19 Small ribosomal subunit protein uS2 Small ribosomal subunit protein uS3 Small ribosomal subunit protein uS4 Small ribosomal subunit protein uS5 Small ribosomal subunit protein uS7 Small ribosomal subunit protein uS9 Ubiquitin-like domain-containing protein Ubiquitin-like domain-containing protein Ubiquitin-like domain-containing protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein	A0A486WX07 G4S0D4 O01504 O01692 O01763 O01802 O01868 O01869 O02056 O02639 O16520 O17218 O17570 O18240 O18650 O44480 O45226 O45499 O45622 O45946 O62388 O76512 P34334 P34662 P37165 P46769 P47991 P48150 P48152 P48154 P48156 P48158 P48166 P49041 P49180 P49181 P49196 P49197 P49405 P50880 P51403 P51404 P52814 P52819 P52821 P61866 P90983 P91053 P91055 P91128 P91374 P91913 P91914 Q09533 Q19162 Q19869 Q19877 Q1XFY9 Q20206 Q20228 Q20647 Q21930 Q22054 Q22716 Q23312 Q27389 Q8WQA8 Q93572 Q93594 Q95Y04 Q95Y90 Q966C6 Q9BKU5 Q9BL19 Q9N3X2 Q9N4I4 Q9NEN6 Q9TXP0 Q9U2A8 Q9U302 Q9U332 Q9XVE9 Q9XVF7 Q9XVP0 Q9XWS4	C16C8.14 C16C8.16 C16C8.20 C37A2.7 CELE_W01D2.1 CELE_Y37E3.8 cbp-20 cbp-80 erfa-1 erfa-3 etf-1 ifg-1 ncbp-1 ncbp-2 pab-1 rla-0 rla-1 rpa-0 rpa-1 rpl-1 rpl-10 rpl-10a rpl-11.2 rpl-12 rpl-13 rpl-14 rpl-15 rpl-16 rpl-17 rpl-18 rpl-19 rpl-2 rpl-20 rpl-21 rpl-22 rpl-23 rpl-24.1 rpl-25.2 rpl-26 rpl-27 rpl-28 rpl-29 rpl-3 rpl-30 rpl-31 rpl-32 rpl-33 rpl-35 rpl-36 rpl-36.A rpl-37a rpl-38 rpl-39 rpl-4 rpl-41 rpl-43 rpl-5 rpl-6 rpl-7 rpl-7A rpl-8 rpl-9 rps-0 rps-1 rps-10 rps-11 rps-12 rps-13 rps-14 rps-15 rps-16 rps-17 rps-18 rps-19 rps-2 rps-20 rps-21 rps-22 rps-23 rps-24 rps-25 rps-26 rps-27 rps-28 rps-29 rps-3 rps-4 rps-5 rps-6 rps-7 rps-8 rps-9 smg-2 ubl-1	Caenorhabditis elegans
Glycogen synthesis	1,4-alpha-glucan branching enzyme Glycogen [starch] synthase Glycogenin-1 Nucleotide-diphospho-sugar transferase Protein phosphatase 1 regulatory subunit UTP--glucose-1-phosphate uridylyltransferase glycogenin glucosyltransferase phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	G5ECZ5 H2KYQ5 O45819 Q21742 Q22137 Q966L7 Q9U2D9 Q9XUS5	CC8.2 CELE_R05F9.6 CELE_T04A8.7 CELE_T10B10.8 gsy-1 gyg-1 gyg-2 rml-1	Caenorhabditis elegans
KSRP (KHSRP) binds and destabilizes mRNA	14-3-3-like protein 1 14-3-3-like protein 2 K Homology domain-containing protein K Homology domain-containing protein K Homology domain-containing protein K Homology domain-containing protein KH domain-containing protein C06G4.1 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2	P34307 P41932 P91393 Q17936 Q17941 Q20655 Q23487 Q9BLA0 Q9XTG7	C06G4.1 akt-1 akt-2 ftt-1 ftt-2 fubl-1 fubl-2 fubl-3 fubl-4 fubp-3.1 fubp-3.2 fubp-3.3 fubp-3.4 par-5	Caenorhabditis elegans
pre-mRNA splicing	ATP-dependent RNA helicase B30.2/SPRY domain-containing protein Beta-catenin-like protein 1 N-terminal domain-containing protein CBF1-interacting co-repressor CIR N-terminal domain-containing protein CID domain-containing protein CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein Cell division cycle 5-like protein Chromatin target of PRMT1 protein C-terminal domain-containing protein Coiled-coil domain-containing protein 12 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 G patch domain-containing protein 1 homolog Gastrulation defective protein 1 General transcription factor IIF subunit 2 Heat shock protein hsp-1 Hepatocellular carcinoma-associated antigen 59 Heterogeneous nuclear ribonucleoprotein A1 Heterogeneous nuclear ribonucleoprotein K homolog Intron-binding protein aquarius K Homology domain-containing protein NF-kappa-B-activating protein C-terminal domain-containing protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Nuclear speckle splicing regulatory protein 1 homolog PHD finger-like domain-containing protein 5A PPIase cyclophilin-type domain-containing protein PWI domain-containing protein Peptidyl-prolyl cis-trans isomerase 10 Peptidyl-prolyl cis-trans isomerase 4 Peptidyl-prolyl cis-trans isomerase sig-7 Peptidyl-prolyl cis-trans isomerase Pinin/SDK/MemA protein domain-containing protein Poly(U)-binding-splicing factor rnp-6 Pre-mRNA-processing factor 19 Pre-mRNA-splicing factor 18 Pre-mRNA-splicing factor 8 homolog Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15 Pre-mRNA-splicing factor CWC22 homolog Pre-mRNA-splicing factor CWC25 homolog Pre-mRNA-splicing factor RBM22 Pre-mRNA-splicing factor SLU7 Pre-mRNA-splicing factor SPF27 Pre-mRNA-splicing factor SYF1 Pre-mRNA-splicing factor syf-2 Probable ATP-dependent RNA helicase DHX35 homolog Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable U2 small nuclear ribonucleoprotein A' Probable histone deacetylase complex subunit SAP18 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5 Probable small nuclear ribonucleoprotein E Probable small nuclear ribonucleoprotein F Probable small nuclear ribonucleoprotein G Probable small nuclear ribonucleoprotein Sm D1 Probable small nuclear ribonucleoprotein Sm D2 Probable small nuclear ribonucleoprotein-associated protein B Probable splicing factor, arginine/serine-rich 2 Probable splicing factor, arginine/serine-rich 3 Probable splicing factor, arginine/serine-rich 4 Probable splicing factor, arginine/serine-rich 6 Probable splicing factor, arginine/serine-rich 7 Proline-rich protein PRCC Protein BUD31 homolog Protein CASC3 Protein FAM32A Protein FAM50 homolog Protein isy-1 Protein mago nashi homolog Putative RNA-binding protein PTB-1a Putative RNA-binding protein R05D3.8 RNA helicase RNA helicase RNA helicase RNA polymerase Rpb4/RPC9 core domain-containing protein RNA-binding protein 5 RNA-binding protein FUS RNA-binding protein rnp-4 RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein Replication stress response regulator SDE2 SAP domain-containing protein STING ER exit protein Schlafen-like protein 2 Serrate RNA effector molecule homolog Small nuclear ribonucleoprotein Sm D3 Spliceosome RNA helicase DDX39B homolog Spliceosome-associated protein CWC15 homolog Splicing factor 45 Splicing factor Cactin Splicing factor YJU2 TPR_REGION domain-containing protein Tr-type G domain-containing protein Transcription initiation factor IIF subunit alpha U2 snRNP-associated SURP motif-containing protein U5 small nuclear ribonucleoprotein 200 kDa helicase UPF3 domain-containing protein Uncharacterized protein F37A4.2 Uncharacterized protein T27F2.1 WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein WW domain-containing protein Zinc finger protein 830 mRNA transport homolog 4	A0A3P6MY32 A9D4S6 B9WRU1 D0G911 G5EBT5 G5EBY6 G5EC45 G5ED97 G5EDE4 G5EDH3 G5EDV3 G5EEL2 G5EEW6 G5EFC4 G5EG14 O01159 O01763 O02092 O02097 O16519 O16786 O18219 O44729 O45431 O45766 O62185 O62213 P09446 P16356 P34313 P34369 P34498 P34541 P34659 P41880 P49029 P52012 P52017 P91156 P91175 P91277 P91306 P91398 P91401 P91918 Q09250 Q09252 Q09385 Q09511 Q09530 Q10013 Q10051 Q10578 Q17336 Q17348 Q17558 Q17684 Q18212 Q18265 Q18409 Q18445 Q18535 Q18691 Q18786 Q18999 Q19211 Q19614 Q19826 Q20124 Q20716 Q20875 Q20966 Q21155 Q21278 Q21322 Q21559 Q21827 Q21832 Q22037 Q22139 Q22412 Q22417 Q22836 Q23120 Q23223 Q23463 Q4W5P0 Q8MXR2 Q8MYM8 Q8WQF3 Q93338 Q93594 Q95Q06 Q95QR5 Q95XJ1 Q95Y67 Q95YF1 Q95ZQ5 Q965K2 Q965S0 Q966L5 Q966L6 Q9BIB7 Q9BIC2 Q9BKQ8 Q9BL61 Q9BLB6 Q9GR61 Q9N3C9 Q9N3S4 Q9N4G9 Q9N5K1 Q9N5K2 Q9NEW6 Q9NLD1 Q9U1Q3 Q9U1Q7 Q9U2G0 Q9U3I0 Q9XTU6 Q9XTZ2 Q9XUW5 Q9XVH6 Q9XVH9	C16C10.4 C47E8.4 CELE_K01G5.8 CELE_T23G11.4 CELE_Y18H1A.2 CELE_Y57G11A.5 CELE_Y66D12A.8 CELE_ZK616.1 E01A2.2 F37A4.2 K07C5.6 R05D3.8 R07E5.1 RBM8 T27F2.1 Y14 acin-1 aly-3 ama-1 bcas-2 bud-31 cacn-1 casc-3 cbp-20 cbp-80 ccdc-12 ccdc-55 cdc-5L cdc-5l cey-1 cey-2 cey-3 cey-4 ctnb-1 cwc-15 cyn-10 cyn-12 cyn-15 cyn-4 cyp-10 cyp-4 ddx-15 ddx-17 ddx-35 ddx-46 eftu-2 eif-4A3 emb-4 fust-1 gad-1 gtf-2F1 gtf-2F2 gtf-2f1 gtf-2f2 hel-1 hrp-1 hrp-2 hrpf-1 hrpf-2 hrpk-1 hrpl-1 hrpr-1 hrpu-1 hsp-1 hsp70a isy-1 let-504 let-858 mag-1 mog-1 mog-2 mog-3 mog-5 mog-6 mtr-4 ncbp-1 ncbp-2 pes-4 phf-5 plrg-1 pnn-1 pqbp-1.1 prcc-1 prp-17 prp-18 prp-19 prp-8 ptb-1 rbm-17 rbm-22 rbm-5 rbp-1 rnp-2 rnp-4 rnp-5 rnp-6 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 rsp-2 rsp-3 rsp-4 rsp-6 rsp-7 rsp-8 rsr-1 sacy-1 sap-1 sap-140 scaf-6 sde-2 sel-13 sig-7 smg-4 snr-1 snr-2 snr-3 snr-4 snr-5 snr-6 snr-7 snrp-200 snrp-40.1 snrp-40.2 sqd-1 srp-1 srp-2 srp-4 syf-1 syf-2 syf-3 tag-65 tofu-2 yju-2	Caenorhabditis elegans
PTK6 Regulates Proteins Involved in RNA Processing	Protein kinase domain-containing protein Protein nipi-4 RRM domain-containing protein Tyrosine-protein kinase	A0A4V0IL59 B3GWA1 O16262 Q9N3S5	CELE_Y47G6A.5 nipi-4 nono-1 trk-1	Caenorhabditis elegans
Activation of G protein gated Potassium channels	G protein gamma domain-containing protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma IRK_C domain-containing protein Inward rectifier potassium channel irk-1 Inward rectifier potassium channel irk-1	A0A1C3NSK2 A0A1C3NSN6 G5ECB2 G5ECT6 H2L0Q3 P17343 P52192 P54406 Q20636	eat-11 gbb-1 gbb-2 gbp-2 gpb-1 gpb-2 gpc-1 gpc-2 irk-1 irk-2 irk-3 irk-4	Caenorhabditis elegans
FGFR2b ligand binding and activation	EGL-17 Myoblast growth factor receptor egl-15 Protein let-756	G5EEF1 Q10656 Q11184	egl-15 egl-17 let-756	Caenorhabditis elegans
DCC mediated attractive signaling	CED-5 CRAL-TRIO domain-containing protein Cell division control protein 42 homolog Homeobox protein ceh-6 Inactive tyrosine-protein kinase kin-32 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Netrin receptor unc-40 Ras-related protein ced-10 Tyrosine protein-kinase src-1	G5EE56 G5EEN3 G5EF96 O61528 P20268 Q03206 Q05062 Q95PX0 Q95YD4	cdc-42 ced-10 ced-5 ceh-6 kin-32 nck-1 rac-1 src-1 unc-40 unc-73	Caenorhabditis elegans
Acyl chain remodelling of PS	C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Lysophospholipid acyltransferase 5 Lysophospholipid acyltransferase PH domain-containing protein Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2	G4RY15 G5EC53 O01925 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q18339 Q22591 Q3V5J7 Q8MPR9 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 CELE_Y69A2AL.2 LPT-1 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 mboa-3 mboa-6 obr-3	Caenorhabditis elegans
Regulation of insulin secretion	EF-hand domain-containing protein Facilitated glucose transporter homolog Facilitated glucose transporter protein 1 Guanylate kinase/L-type calcium channel beta subunit domain-containing protein MFS domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein Major facilitator superfamily (MFS) profile domain-containing protein SH3 domain-containing protein Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent calcium channel unc-36	A0A078BQJ0 A0A3B1E663 G5EC93 O01661 O16547 O44616 O44827 O45920 P34374 Q19376 Q20734 Q21381 Q21382 Q21385 Q23535 Q23626 Q5WRR9 Q8MQA1 Q95QY6 Q9GPA2 Q9GYQ1 Q9N309 Q9NEI8 Q9U2K5 Q9XU83 Q9XVL3	C03B1.13 C35A11.4 CELE_F11D5.5 CELE_F11D5.7 CELE_F13B12.2 CELE_F48E3.2 CELE_F53H8.3 CELE_K08F9.1 CELE_K08H10.6 CELE_K09C4.1 CELE_K09C4.4 CELE_K09C4.5 CELE_Y37A1A.3 CELE_Y39B6A.41 CELE_Y39E4B.5 CELE_Y61A9LA.1 CELE_ZK829.9 R09B5.11 ccb-1 ccb-2 egl-19 fdgt-2 fgt-1 slcf-2 unc-2 unc-36 unc-72	Caenorhabditis elegans	G58161NS
Drug-mediated inhibition of ERBB2 signaling	Heat shock protein 90 Probable Hsp90 co-chaperone cdc37 Receptor tyrosine-protein kinase let-23	O02108 P24348 Q18688	cdc-37 daf-21 kin-7 let-23	Caenorhabditis elegans
Synthesis of very long-chain fatty acyl-CoAs	Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Elongation of very long chain fatty acids protein Long chain fatty acid elongase 1 Long chain fatty acid elongase 2 Long chain fatty acid elongase 5 Long chain fatty acid elongase 6 Long-chain-fatty-acid--CoA ligase Probable very-long-chain enoyl-CoA reductase art-1 Putative fatty acid elongase 3 Putative fatty acid elongase 4 Uncharacterized oxidoreductase dhs-5 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase long-chain-fatty-acid--CoA ligase long-chain-fatty-acid--CoA ligase	A0A4V0ING4 F3Y5R4 G5EEE5 O17040 P49191 Q03574 Q10130 Q20121 Q20300 Q20303 Q20904 Q21905 Q9N5Y2 Q9NAC6 Q9XVQ9 V6CLI5	CELE_R10E4.9 acs-13 acs-17 acs-4 art-1 dhs-5 elo-1 elo-2 elo-3 elo-4 elo-5 elo-6 elo-7 elo-8 elo-9 hpo-8	Caenorhabditis elegans
RAC2 GTPase cycle	Arf-GAP domain-containing protein Armadillo repeat-containing domain-containing protein CED-5 CRAL-TRIO domain-containing protein Cadherin-4 Calponin-homology (CH) domain-containing protein Caveolin-1 Caveolin-2 Cell division control protein 42 homolog Cytoplasmic FMR1-interacting protein homolog DH domain-containing protein DH domain-containing protein Ephrin receptor 1 Glutamate carboxypeptidase 2 homolog MAGUK family Membrane-associated protein gex-3 Metaxin-1 homolog N-acetylated-alpha-linked acidic dipeptidase 2 PH domain-containing protein Phosphatidylinositol 3-kinase age-1 Phosphoinositide 3-kinase adapter subunit Phospholipase Probable rho GDP-dissociation inhibitor Protein BRICK1 Protein let-99 Protein vav-1 Rac GTPase-activating protein 1 Ras-related protein Rab-18 Ras-related protein Rab-7a Ras-related protein ced-10 Ras-related protein rac-2 Rho GTPase-activating protein 26 Rho GTPase-activating protein 68F Rho GTPase-activating protein syd-1 Rho-GAP domain-containing protein Rho-GAP domain-containing protein SAM50-like protein gop-3 SH3 domain-containing protein Serine/threonine-protein kinase SULU Serine/threonine-protein kinase max-2 Serine/threonine-protein kinase pak-1 Serine/threonine-protein kinase pak-2 Synaptobrevin-1 Target of ERK kinase mpk-1 Uncharacterized integrin beta-like protein C05D9.3 Vang-like protein WAPL domain-containing protein Wiskott-Aldrich syndrome protein family member	A0A0K3AR51 A0A2K5AU23 A5Z2X2 G5EDP9 G5EDU3 G5EEN3 G5EFU0 G5EGQ3 H2KY90 H2KYI7 H2KZH5 H2KZV6 O01847 O02495 O17772 O44518 O45503 O45611 O61460 O61528 P46549 P46576 P55163 P91406 Q03206 Q05062 Q10929 Q17850 Q18879 Q19319 Q19467 Q20496 Q21341 Q23130 Q23146 Q45FX5 Q7JP75 Q86NH1 Q93332 Q94051 Q94124 Q94125 Q95XW5 Q9BL44 Q9GYK2 Q9U1V2 Q9XUS9 Q9XVK6	C05D9.3 CELE_F22G12.5 CELE_T04C9.1 CELE_Y57G11C.1147 CELE_Y67A10A.7 CELE_Y71H2AM.12 PLD aap-1 abi-1 age-1 cav-1 cav-2 cdc-42 cdh-4 ced-10 ced-5 cgef-1 cyk-1 cyk-4 gcp-2.1 gcp-2.2 gex-2 gex-3 git-1 gop-3 kin-18 let-99 magu-1 max-2 mtx-1 pak-1 pak-2 pes-7 pld-1 rab-7 rac-1 rac-2 rga-1 rga-5 rga-8 rhi-1 snb-1 sulu syd-1 tiam-1 toe-2 unc-73 vab-1 vang-1 vav-1 wve-1	Caenorhabditis elegans
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Inositol 1,4,5-trisphosphate receptor itr-1 Stromal interaction molecule 1 Transient receptor ion channel domain-containing protein	G5EF60 Q8I6Y9 Q9Y0A1	dec-4 itr-1 lfe-1 stim-1 trp-2	Caenorhabditis elegans
Heme degradation	ABC transmembrane type-1 domain-containing protein ABC transporter domain-containing protein ABC transporter family G domain-containing protein Fatty acid-binding protein homolog 5 Fatty acid-binding protein homolog 6 Fatty acid-binding protein homolog 7 Fatty acid-binding protein homolog 8 Multidrug resistance protein mrp-7 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Multidrug resistance-associated protein 1 Solute carrier organic anion transporter family member	D7SFK1 G5EFP3 O01812 O01814 O02323 O02324 Q19048 Q19585 Q20943 Q3S1M2 Q93550 Q9U2G5 Q9XW61	CELE_F21G4.1 abcx-1 lbp-5 lbp-6 lbp-7 lbp-8 mrp-1 mrp-2 mrp-3 mrp-4 mrp-7 mrp-8 wht-5	Caenorhabditis elegans
EPH-ephrin mediated repulsion of cells	AP complex subunit beta AP complex subunit sigma AP-2 complex subunit alpha AP-2 complex subunit mu Clathrin light chain DH domain-containing protein Dynamin Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin RBD domain-containing protein Ephrin receptor 1 Ephrin-4 Gamma-secretase subunit aph-1 Gamma-secretase subunit pen-2 MMP-like protein Matrix metalloproteinase-A Matrix metalloproteinase-B Matrix metalloproteinase-C Nicastrin Peptidase metallopeptidase domain-containing protein Presenilin sel-12 Probable clathrin heavy chain 1 Protein vav-1 Ras-related protein ced-10 Tyrosine protein-kinase src-1 Uncharacterized protein	G5EBU3 G5ECC4 G5EE56 G5EEE7 G5EGM1 O01847 O17913 O44516 O44836 O45876 O61460 P34574 P35603 P39055 P52166 P90961 Q03206 Q19123 Q19475 Q21182 Q22601 Q23316 Q45FX5 Q9N4F3 Q9U357 Q9U3M2	CELE_K03B8.6 ap50 apa-2 apb-1 aph-1 aph-2 aps-2 ced-10 chc-1 clic-1 dpy-23 dyn-1 efn-2 efn-3 efn-4 mab-26 pen-1 pen-2 rac-1 sel-12 src-1 tiam-1 vab-1 vab-2 vav-1 zmp-1 zmp-2 zmp-3 zmp-5 zmp-6	Caenorhabditis elegans

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